FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Ispagnac Participacoes Ltda.
   2. Issuer Name and Ticker or Trading Symbol
CODEXIS INC [CDXS] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
AVENIDA DAS AMERICAS, 4200 BLOCO 6,, 1O ANDAR, (PART) BARRA DA TIJUCA		 3. Date of Earliest Transaction (Month/Day/Year)
06/01/2011
(Street)

RIO DE JANEIRO, RJ CEP, D5 22640-102		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/01/2011   J(1)   5,573,319 D (1) 5,573,319 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Ispagnac Participacoes Ltda.
AVENIDA DAS AMERICAS, 4200 BLOCO 6,
1O ANDAR, (PART) BARRA DA TIJUCA
RIO DE JANEIRO, RJ CEP, D5 22640-102		     X    
Royal Dutch Shell plc
30, CAREL VAN BYLANDTLAAN
THE HAGUE, P7 2596 HR		     X    

Signatures

 /s/ Mark Edwards for Royal Dutch Shell Plc as its Deputy Company Secretary   06/01/2011
**Signature of Reporting Person Date
 /s/ Matias Lopes for Ispagnac Participacoes Ltda. as an Officer   06/01/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Disposition of Codexis Common Stock by Ispagnac Participacoes Ltda., an indirect wholly owned subsidiary of Royal Dutch Shell plc ("RDS"), to Raizen Energia Participacoes S.A. ("Raizen"), a joint venture company in which RDS is indirectly a joint venture partner, was part of RDS's and its affiliates' contribution to such joint venture, and was made in exchange for Raizen capital stock.

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