UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

Date of report (Date of earliest event reported): June 8, 2011

Codexis, Inc.

(Exact name of Registrant as Specified in its Charter)

200 Penobscot Drive

Redwood City, CA 94063

(Address of Principal Executive Offices) (Zip Code)

(650) 421-8100

(Registrant’s telephone number, including area code)

Not Applicable

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

(b) On June 9, 2011, Mr. Chris Streng resigned as a member of the Board of Directors (the “Board”) of Codexis, Inc. (the “Company”), effective as of such date. Mr. Streng served on the Board as a representative of Equilon Enterprises LLC dba Shell Oil Products US (“Equilon”), pursuant to the Voting Agreement among the Company, Equilon and certain other former holders of the Company’s preferred stock (which was converted into common stock at the time of the Company’s initial public offering) (the “Voting Agreement”), which gave Equilon a right to designate one director to the Board subject to the terms and conditions contained therein. Mr. Streng’s resignation was a result of the transfer by Equilon of 5,573,319 shares of the Company’s common stock to Raízen Energia Participações S.A. (“Raízen”) and the assumption by Raízen of certain of Equilon’s rights in respect of such shares, including Equilon’s right to designate a representative to the Board pursuant to the Voting Agreement. The transfer and assumption described in the previous sentence was previously disclosed in a Current Report on Form 8-K, filed with the Securities and Exchange Commission on June 3, 2011.

The Company held its Annual Meeting of Stockholders on June 8, 2011 in Redwood City, California. The results of the matters voted on by the Company’s stockholders are set forth immediately below.

Proposal 1

To elect two (2) Class I Directors to the Company’s Board of Directors to hold office until the 2014 Annual Meeting of Stockholders or until their respective successors are elected and qualified or their earlier resignation or removal:

Proposal 2

To ratify the selection of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2011:

Proposal 3

To hold a non-binding, advisory vote on the following resolution relating to the compensation of the Company’s named executive officers:

“RESOLVED, that the compensation paid to Codexis, Inc.’s named executive officers, as disclosed in the proxy statement for the 2011 Annual Meeting of Stockholders pursuant to Item 402 of Regulation S-K, including the disclosure under the heading ‘Executive Compensation,’ is hereby approved.”

Proposal 4

To hold a non-binding, advisory vote on the frequency of future advisory votes on compensation for the Company’s named executive officers:

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: June 14, 2011