[***] Certain information in this document, indicated by brackets, has been excluded pursuant to Regulation S-K, Item 601(b)(10)(iv). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed.
Exhibit 10.13A
PLATFORM TECHNOLOGY TRANSFER AND LICENSE AGREEMENT
THIS PLATFORM TECHNOLOGY TRANSFER AND LICENSE AGREEMENT (together with any exhibits attached hereto, this “Agreement”) is made and entered into as of August 3, 2015 (the “Effective Date”), by and between Codexis, Inc., a corporation organized and existing under the laws of Delaware (“Codexis”), and Merck Sharp & Dohme Corp., a corporation organized and existing under the laws of New Jersey (“Merck”). Codexis and Merck are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”
RECITALS
WHEREAS, Codexis possesses expertise in the engineering and optimization of biocatalysts for use in pharmaceutical compound synthesis and manufacture;
WHEREAS, Merck seeks to develop biocatalytic approaches to synthesize compounds of interest to Merck and to practice the Platform Technology under the licenses granted by Codexis and in connection with a technology transfer from Codexis; and
WHEREAS, Codexis desires to grant to Merck such license and perform such technology transfer, on the terms and conditions set forth herein.
AGREEMENT
NOW, THEREFORE, in consideration of the foregoing premises and the mutual promises, covenants and conditions contained in this Agreement, the Parties agree as follows:
1. DEFINITIONS. The terms in this Agreement with initial letters capitalized, whether used in the singular or the plural, shall have the meaning set forth below.
1.1 “Additional Services” means any enzyme evolution related services performed by Codexis pursuant to Section 4.2 of this Agreement.
1.2 “Affiliate” means any Person that directly or indirectly is controlled by, controls or is under common control with a Party to this Agreement. For the purposes of this definition, the term “control” (including, with correlative meanings, the terms “controlled by” and “under common control with”) as used with respect to a Person means (a) in the case of a corporate entity, direct or indirect ownership of voting securities entitled to cast more than fifty percent (50%) of the votes in the election of directors, (b) in the case of a non-corporate entity, direct or indirect ownership of more than fifty percent (50%) of the equity interests with the power to direct the management and policies
of such entity, or (c) any other arrangement whereby a Person controls or has the right to control the board of directors or equivalent governing body or management of a corporation or other entity; provided that, if local Applicable Law restricts foreign ownership, control shall be established by direct or indirect ownership of the maximum ownership percentage that may, under such local Applicable Law, be owned by foreign interests.
1.3 “Agreement Payments” means all amounts, fees, royalties, and other payments made by Merck to Codexis under this Agreement.
1.4 “Applicable Law” means all applicable laws, statutes, rules, regulations, ordinances and other pronouncements having the effect of law of any federal, national, multinational, state, provincial, county, city or other political subdivision, government or Regulatory Authority.
1.5 “Approved Server” means physical or virtual computer server(s) that are (i) required for the operation of the Codexis Software, (ii) controlled by Merck or its designated Third Party cloud service provider, and (iii) meet all hardware specifications, software specifications, and other specifications and requirements specified by Codexis for the proper operation of the Codexis Software.
1.6 “Arising Codexis Enzyme Technology” means: (a) the amino acid sequence and structure of any Covered Enzyme or Enzyme developed under any of a Technology Transfer Project or an Evolution Program or during Additional Services and (b) structure activity data that describes the structure activity relationship and other characteristics of any Covered Enzyme(s) or Enzyme(s) noted in (a), and in each of (a) and (b), which data and information are Controlled by Codexis. For the avoidance of doubt, Arising Codexis Enzyme Technology shall not include any of the foregoing (a) or (b) developed outside of a Technology Transfer Project or an Evolution Program or during Additional Services.
1.7 “Arising Codexis Enzyme Technology IP” means Intellectual Property Rights which have arisen directly from the Arising Codexis Enzyme Technology. For clarity, the Arising Codexis Enzyme Technology IP excludes any Background IP of Merck, any Arising Merck Process Technology IP, any Arising Merck Enzyme Technology IP, and any Merck API Process Technology IP.
1.8 “Arising Codexis Process Technology” means methods of using Covered Enzyme(s) or Enzyme(s) in compound synthesis, developed under either a Technology Transfer Project or an Evolution Program or during Additional Services and which methods are Controlled by Codexis; provided that Arising Codexis Process Technology shall exclude technology that is
generally applicable to chemical process development and to the synthesis and scale-up of small molecule compounds and that does not specifically require the use or performance of such Covered Enzyme or Enzyme.
1.9 “Arising Codexis Process Technology IP” means Intellectual Property Rights which have arisen directly from the Arising Codexis Process Technology. For clarity, the Arising Codexis Process Technology IP excludes any Background IP of Merck, any Arising Merck Process Technology IP, any Arising Merck Enzyme Technology IP, and any Merck API Process Technology IP.
1.10 “Arising Merck Enzyme Technology” means the Technology related to any Covered Enzyme or Enzyme created, developed, or invented solely by Merck. For clarity, no Covered Enzyme or Enzyme created, developed, or invented during a Technology Transfer Program or an Evolution Program or Additional Services will be deemed to have been solely developed by Merck.
1.11 “Arising Merck Enzyme Technology IP” means Intellectual Property Rights which have arisen directly from the Arising Merck Enzyme Technology. For clarity the Arising Merck Enzyme Technology IP excludes any Background IP of Codexis, any Arising Codexis Process Technology IP and any Arising Codexis Enzyme Technology IP.
1.12 “Arising Merck Process Technology” means any Process Technology that is created, developed, or invented solely by Merck or jointly by Merck and Codexis.
1.13 “Arising Merck Process Technology IP” means Intellectual Property Rights which have arisen directly from the Arising Merck Process Technology. For clarity, the Arising Merck Process Technology IP excludes any Background IP of Codexis, any Arising Codexis Process Technology IP, any Arising Codexis Enzyme Technology IP and any Arising Merck Enzyme Technology IP.
1.14 “Background IP” means any and all Intellectual Property Rights which are Controlled by a Party and (a) exist as of the Effective Date and/or (b) arise during the Term independently of the other Party and this Agreement.
1.15 “Business Day” means a day other than Saturday, Sunday or any day on which commercial banks located in New York, New York are authorized or obligated by Applicable Law to close.
1.16 “Calendar Quarter” means the period beginning on the Effective Date and ending on the last day of the calendar quarter in which the Effective Date falls and, thereafter, each successive period of three (3) consecutive calendar months ending on March 31, June 30, September 30 or December 31.
1.17 “Calendar Year” means the period beginning on the Effective Date and ending on December 31st of the calendar year in which the Effective Date falls, and thereafter, each successive period of twelve (12) consecutive calendar months commencing on January 1 and ending on December 31.
1.18 “Claim” means any claim, demand, cause of action, suit, dispute, proceeding, arbitration, audit, hearing, investigation or inquiry (whether formal or informal).
1.19 “Codexis Core Patents” means the Patents set forth on Exhibit 1.19.
1.20 “Codexis Core Technology” means those (i) tools, processes and methods Controlled by Codexis; and (ii) generally applicable tools, processes and methods which Codexis has the ability to transfer to or license to Merck, in each of (i) and (ii) above: (a) used to identify, select, optimize, isolate, modify, engineer, research, develop, make, have made and/or import enzymes, Covered Enzymes and Enzymes, through the recombination and/or rearrangement and/or mutation of genetic material for the creation of genetic diversity, using any methods, including but not limited to Codexis Software, in silico, in vitro, and and/or in vivo technologies, (b) screening techniques, methodologies and/or processes of using the resulting genes and/or proteins to identify and assess their potential utility, (c) gene expression methods applicable in high throughput screening, (d) cultivation of microorganisms, (e) techniques for producing, harvesting, and/or purifying proteins, and (f) including the Codexis Software, in each of (a) – (f) above, as described in Exhibit 1.20.
1.21 “Codexis Core Technology Improvements” means any Improvement to the Codexis Core Technology practiced by Codexis or any Affiliate of Codexis which are licensed to Merck under Section 3.2, that is generated by Codexis, or both Parties, or on behalf of Codexis or both Parties, or by Codexis with a Third Party, during the TT Term (and, if Merck exercises the Option, during the Improvements TT Term) and is Controlled by Codexis, excluding any Improvement to the Codexis Core Technology which arises from Merck’s Background IP.
1.22 “Codexis Core Technology Improvements IP” means any and all Intellectual Property Rights which is generated by or on behalf of Codexis or any Affiliate of Codexis or jointly between the Parties or any Affiliate of the Parties which Covers the Codexis Core
Technology Improvements. For clarity, the Codexis Core Technology Improvements IP excludes any Background IP of Merck, any Arising Merck Process Technology IP, any Arising Merck Enzyme Technology IP, and any Merck API Process Technology IP.
1.23 “Codexis Documentation” means any documentation disclosed by Codexis to Merck pursuant to Article 2 (including with respect to the Platform Technology and any Improvements), including all documentation relating to the Codexis Methods, the Technology Transfer Plan, and documentation related to the Codexis Software and the documentation described in the Technology Transfer Plan and any and all copies thereof, in whole or in part.
1.24 “Codexis Enzymes” means any Covered Enzyme which is Controlled by Codexis and transferred to Merck pursuant to the Technology Transfer Plan.
1.25 “Codexis Enzyme Patents” means the Patents set forth on Exhibit 1.25.
1.26 “Codexis Initial Enzyme(s)” means any Codexis Enzyme or any Enzyme contained within a Codexis Library which is designated as an Initial Enzyme pursuant to a Technology Transfer Project.
1.27 “Codexis Library” means any collection, set or sub-set of expression vectors containing genes Controlled by Codexis that encode for Covered Enzymes, Enzymes or enzymes, transferred to Merck under the Technology Transfer Plan, for the propagation of additional enzyme stock.
1.28 “Codexis Materials” means all biocatalytic materials disclosed or transferred to Merck by Codexis under and specifically in furtherance of this Agreement, including, without limitation, (a) the Codexis Libraries and Codexis Enzymes, and (b) kits and plates generally consisting of multiple, genetically-diverse enzymes that are made commercially available to the general public by Codexis through Codexis’ catalog or website.
1.29 “Codexis Mayflower Patents” means the Patents set forth on Exhibit 1.29.
1.30 “Codexis Methods” means (a) as of the Effective Date, the methods and protocols listed in Appendix IV of the Technology Transfer Plan, and (b) after the Effective Date, the methods and protocols disclosed by Codexis and drafted by Codexis documenting in sufficient detail to enable a scientist with reasonable skills and experience in the field of protein engineering or protein biochemistry to practice the Platform Technology. The Codexis Methods shall include the most current and complete procedures used by Codexis as of the date on which they are disclosed to Merck with respect to the procedures described therein.
1.31 “Codexis Software” means [***], and all other software disclosed under the Technology Transfer Plan, as amended from time to time, together with all software Controlled by Codexis and disclosed by Codexis under this Agreement, including all versions and improvements practiced by Codexis during the TT Term, in each case solely in executable form.
1.32 “Commercially Reasonable Efforts” means, with respect to a Party’s obligations under this Agreement, efforts consistent with the efforts and resources normally used by a similarly situated pharmaceutical, biotechnology or technology company in the exercise of its reasonable business discretion relating to the development or commercialization of a product with similar product characteristics that is of similar market potential at a similar stage of development or commercialization, taking into account issues of efficacy, safety, patent and regulatory exclusivity, product profile, anticipated or approved labeling, present and future market potential, competitive market conditions, the proprietary position of the compound or product, the regulatory structure involved, and other technical, legal, scientific, medical or commercial factors, and the profitability of the product, including in light of pricing and reimbursement issues.
1.33 “Completion of Wave 1” means the achievement of the Wave 1 Milestone Success Criteria as defined under the Technology Transfer Plan.
1.34 “Completion of Wave 2” means the achievement of the Wave 2 Success Criteria as defined under the Technology Transfer Plan.
1.35 “Controlled” or “Controls” means, when used in reference to an item of Technology or to Intellectual Property Rights, the legal authority or right of a Party (whether directly or through any of its Affiliates to the extent a Party has the requisite authority), whether by ownership, assignment or by license, other than pursuant to this Agreement, to grant the right to use such item of Technology or a license or sublicense of such Intellectual Property Rights to the other Party, or to otherwise disclose proprietary or trade secret information to such other Party, without violating any Applicable Law, breaching the terms of any agreement with any Third Party, or misappropriating the proprietary or trade secret information or other Intellectual Property Rights of a Third Party.
1.36 “Cover” or “Covers” means, a particular item or method encompassed by any Intellectual Property Rights, that, but for a license under or ownership right in such Intellectual Property Rights, the use, making, having made, offering for sale, sale, importation, or other exploitation of such item would infringe or misappropriate such Intellectual Property Rights (assuming, in the case of pending Patent applications, that such pending Patent applications were issued Patents).
1.37 “Covered Enzyme” means any enzyme that is Covered by the Licensed IP.
1.38 “Designated Lab” means the laboratory(ies) selected by Merck and specified in the Technology Transfer Plan which are located at a single Merck facility in the continental United States and designated to implement the Platform Technology. As of the Effective Date, the Designated Lab will be located at the single Merck facility set forth in Exhibit 1.38. Merck may, upon written notice to Codexis, change the location of a Designated Lab to another single Merck facility within the continental United States.
1.39 “Diagnostic” means [***].
1.40 “Dollar” or “$” means the lawful currency of the United States.
1.41 “enzyme” (without initial capital) means an immature or mature peptide or protein (including derivatives) with enzymatic or biocatalytic activity.
1.42 “Enzyme” means any enzyme which is derived from the use of the Platform Technology pursuant to this Agreement.
1.43 “Excluded Claim” mean a dispute, controversy or claim between the Parties that concerns: [***].
1.44 “FDA” means the U.S. Food and Drug Administration, or any successor agency thereto.
1.45 “Fee Bearing Therapeutic Product” means a Therapeutic Product for which development was initiated during the Initiation Period.
1.46 “FTE” means the equivalent of the work of one (1) Codexis scientist, or one (1) Merck scientist, as the case may be, full time for one (1) year. In no event will one (1) person count for more than one (1) FTE in any year.
1.47 “U.S. GAAP” means generally accepted accounting principles adopted by the U.S. Securities and Exchange Commission, consistently applied.
1.48 “Generic Version” means, with respect to a Therapeutic Product, that a Third Party is manufacturing and supplying on a commercial scale a pharmaceutical product therapeutically equivalent to the Therapeutic Product without infringing any Intellectual Property Rights Controlled by Merck or Codexis and such pharmaceutical product is A/B Rated with respect to a Therapeutic Product. For the purposes of this definition, “A/B Rated” means, inside the United States, “therapeutically equivalent” as evaluated by the FDA, applying the definition of
“therapeutically equivalent” set forth in the preface to the then-current edition of the FDA publication “Approved Drug Products With Therapeutic Equivalence Evaluations” and, outside the United States, such equivalent determination by the applicable Regulatory Authorities as is necessary to permit pharmacists or other individuals authorized to dispense pharmaceuticals under Applicable Law to substitute one product for another product in the absence of specific instruction from a physician or other authorized prescriber under Applicable Law.
1.49 “Good Clinical Practices” or “GCP” means the then-current international ethical and scientific quality standards for designing, conducting, recording and reporting trials that involve the participation of human subjects. In the United States, GCP shall be based on Good Clinical Practices established through FDA guidance (including ICH E6) and, outside the United States, GCP shall be based on ICH E6.
1.50 “Good Laboratory Practices” or “GLP” means the then-current Good Laboratory Practice (or similar standards) for the performance of laboratory activities for pharmaceutical products as are required by applicable Regulatory Authorities or Applicable Law. In the United States, Good Laboratory Practices are established through FDA regulations (including 21 C.F.R. Part 58), FDA guidance, FDA current review and inspection standards and current industry standards.
1.51 “Good Manufacturing Practices” or “GMP” means the then-current Good Manufacturing Practices for the manufacture of products as are required by applicable Regulatory Authorities or Applicable Law. In the United States, GMP shall be as defined under the rules and regulations of the FDA, as the same may be amended from time to time.
1.52 “Improvement” means an enhancement, extension, upgrade, improvement, derivative work, or update.
1.53 “Improvements TT Term” means the period beginning on the expiration of the TT Term and continuing until and ending on the earlier of (a) the Improvements TT Term Expiration Date, or (b) the early termination of this Agreement by Codexis in accordance with Sections 12.2, 12.3, 12.4 or 12.5.
1.54 “Improvements TT Term Expiration Date” means the [***] year anniversary of the TT Term Expiration Date or a later date if the Improvements TT Term is extended in accordance with Section 3.5.7.
1.55 “Information” means any and all information and data, including without limitation all Know-How and all other scientific, pre-clinical, clinical, regulatory, manufacturing,
marketing, financial and commercial information or data, whether communicated in writing or orally or by any other method, which is provided by one Party to the other Party in connection with this Agreement.
1.56 “Initial Enzyme” means the single Merck Initial Enzyme or Codexis Initial Enzyme contributed to a Technology Transfer Project which is selected to undergo Initial Enzyme Optimization. Once an Initial Enzyme is selected, such selection may only be changed by mutual written consent of the Parties.
1.57 “Initial Enzyme Optimization” means the process of optimizing an Initial Enzyme.
1.58 “Initial Technology Transfer Inventory” means all of the items set out in Appendices I, II and III of the Technology Transfer Plan.
1.59 “Initiation Period” means the period beginning on the TT Term Expiration Date and ending on the earlier of (a) the date that is ten (10) years after the TT Term Expiration Date, or (b) the termination of this Agreement.
1.60 “In-License Agreements” means all agreements pursuant to which any Licensed IP is licensed or sublicensed to Codexis from a Third Party and which are listed in Exhibit 1.60.
1.61 “In-Licensed IP” means the In-Licensed Patents and any In-Licensed Know-How.
1.62 “In-Licensed Know-How” means all Know-How of Third Parties Controlled by Codexis as of the Effective Date and licensed to Codexis pursuant to the In-License Agreements, in each case that Covers the Codexis Documentation, the Codexis Materials, Know-How related to the operation of the Codexis Software (but excluding the Codexis Software itself) or the practice of the Platform Technology.
1.63 “In-Licensed Patents” means the Patents set forth on Exhibit 1.63.
1.64 “Intellectual Property Rights” means Patents, Know-How and copyrights, including all applications for registration for the foregoing and all other similar proprietary rights as may exist anywhere in the world.
1.65 “Internal Research Purposes” means scientific research programs in the animal and/or human healthcare field conducted internally by Merck or its Affiliates, which are
specifically directed to the purposes of their internal research, but excluding the discovery of novel Therapeutics [***].
1.66 “Invention” means any discovery, invention, contribution, method, finding, or improvement, whether or not patentable, and all related Know-How.
1.67 “Invoice” means any invoice submitted to Merck by Codexis under this Agreement, produced in accordance with Merck’s processing requirements.
1.68 “Know-How” means non-public materials and technical information, including techniques, methods, processes, technology, recipes, formulae, designs, equipment configurations and uses, biological samples, compounds and cell lines, and biological, chemical, pharmacological, toxicological, clinical, assay and related trade secrets, manufacturing data, preclinical and clinical data, specifications, ingredients, manufacturing processes, formulation, specifications, sourcing information, quality control and testing procedures, and related know-how and trade secrets and including all of the foregoing related to the operation of the Codexis Software, but in each case excluding the Codexis Software itself.
1.69 “knowledge of Codexis Senior Management” means, with respect to any matter in question, that any of Codexis’ [***]
[***] is actually aware or has actual knowledge of such matter [***].
1.70 “Licensed Additional Codexis Know-How” means any and all Know-How which (a) Codexis or any Codexis Affiliate comes to Control during the TT Term (and, if Merck exercises the Option, during the Improvements TT Term) and which Covers (i) the Platform Technology, (ii) Arising Codexis Enzyme Technology, (iii) Arising Codexis Process Technology, (iv) any Codexis Core Technology Improvements, (v) the Codexis Documentation, or (vi) Codexis Materials and including any Know-How related to the operation of the Codexis Software, but in each case excluding the Codexis Software itself, and (b) Codexis or any Codexis Affiliate comes to Control during the Term and which Covers the Merck Core Technology Improvements.
1.71 “Licensed Additional Codexis Patents” means any and all Patents which (a) Codexis or any Affiliate comes to Control during the TT Term (and, if Merck exercises the Option, during the Improvements TT Term) and which Covers (i) the Platform Technology, (ii) Arising Codexis Enzyme Technology, (iii) Arising Codexis Process Technology, or (iv) any Codexis Core Technology Improvements and (b) Codexis or any Codexis Affiliate comes to Control during the Term and which Covers the Merck Core Technology Improvements.
1.72 “Licensed IP” means (a) the Licensed Patents, (b) the In-Licensed Patents (c) the Licensed Know-How, (d) the In-Licensed Know-How, (e) the Licensed Additional Codexis Know-How and (f) the Licensed Additional Codexis Patents.
1.73 “Licensed Know-How” means any Know-How Controlled by Codexis as of the Effective Date which is disclosed or provided to Merck pursuant to the Technology Transfer Plan, including the Codexis Documentation, Codexis Materials and Know-How related to the operation of the Codexis Software (but excluding the Codexis Software itself), but only to the extent existing as of the Effective Date.
1.74 “Licensed Patents” means the Codexis Core Patents, the Codexis Mayflower Patents and the Codexis Enzyme Patents.
1.75 “Losses” means any liability, loss, damage, expense (including reasonable legal expenses, costs of litigation, and attorneys’ fees) or judgment, whether for money or equitable relief, of any kind.
1.76 “Merck API Process Technology” means all Technology (excluding however any Process Technology) of or relating to manufacturing or processing an active pharmaceutical ingredient, in either case which Technology relates to a specific active pharmaceutical ingredient, including any Merck Developed API, developed by or for (other than any Technology developed by Codexis on behalf of Merck or any of its Affiliates) or otherwise Controlled by Merck, but in each case excluding the Codexis Software.
1.77 “Merck API Process Technology IP” means all Intellectual Property Rights of any kind or nature in or to any Merck API Process Technology.
1.78 “Merck Core Technology Improvements” means any Improvement to the Codexis Core Technology practiced by Merck or any Affiliate of Merck that is generated solely by Merck during the Term, excluding any Improvement to the Codexis Core Technology which arises from Merck’s Background IP.
1.79 “Merck Core Technology Improvements IP” means any and all Intellectual Property Rights which are generated solely by Merck or any Affiliate of Merck which Cover the Merck Core Technology Improvements. For clarity, the Merck Core Technology Improvements IP excludes any Background IP of Merck, any Arising Merck Process Technology IP, any Arising Merck Enzyme Technology IP, and any Merck API Process Technology IP.
1.80 “Merck Developed API” means any active pharmaceutical ingredient, where such active pharmaceutical ingredient is owned or Controlled by Merck and developed and/or manufactured by Merck using at least one (1) Enzyme.
1.81 “Merck Exclusive Field” means the research, development, and manufacture of Covered Enzymes and Enzymes for use in the animal and/or human healthcare field solely by Merck and its Affiliates, or on behalf of Merck and its Affiliates in accordance with Section 3.2, in the chemical synthesis of Therapeutic Products owned or Controlled by Merck (including, for clarity, the chemical synthesis of Merck Developed APIs for formulation into any Therapeutic Controlled by Merck), but excluding, in any event, the discovery of any Therapeutic Enzyme, Diagnostic, or Vaccine.
1.82 “Merck Initial Enzyme(s)” means any enzyme (which for clarity is not an “Enzyme”) that is provided by Merck and which is designated as an Initial Enzyme pursuant to a Technology Transfer Project excluding, for clarity, Enzymes derived from a Codexis Enzyme or a Codexis Library.
1.83 “Merck Non-Exclusive Field” means the research, development, and manufacture of Covered Enzymes and Enzymes for use solely by Merck and its Affiliates, or on behalf of Merck and its Affiliates in accordance with Section 3.2, for Internal Research Purposes, but excluding, in any event, the discovery of any Therapeutic Enzyme, Diagnostic, or Vaccine, or any sale, lease, license, transfer or use of such Covered Enzymes or Enzymes as a standalone product or a component of a product.
1.84 “Merck Project Library” means any collection, set or sub-set of Enzymes and/or expression vectors containing genes that encode for Enzymes derived from a Technology Transfer Project.
1.85 “Option Improvements” means all Improvements relating to the Platform Technology, including, without limitation, Codexis Core Technology Improvements (including any and all Improvements to the Codexis Methods, the Initial Technology Transfer Inventory and the Codexis Software), Improvements to the Codexis Materials and/or the Codexis Documentation, which have come to be Controlled by Codexis during the applicable Option Year.
1.86 “Option Year” means each of the [***] twelve (12)-month periods commencing with the day immediately following the TT Term Expiration Date and thereafter commencing with each anniversary thereof. For clarity, the [***].
1.87 “Patent(s)” means (a) patents and patent applications anywhere in the world, (b) all divisionals, continuations, continuations in-part thereof or any other patent application claiming priority, or entitled to claim priority, directly or indirectly to (i) any such patents or patent applications, or (ii) any patent or patent application from which such patents or patent applications claim, or is entitled to claim, direct or indirect priority, (c) all patents issuing on any of the foregoing anywhere in the world, together with all registrations, reissues, re-examinations, patents of addition, renewals, substitutions, validations, and re-validations, supplemental protection certificates or extensions of any of the foregoing anywhere in the world, and (d) all provisional and any other priority patent applications filed worldwide.
1.88 “Person” means any individual, firm, corporation, partnership, limited liability company, trust, business trust, joint venture, governmental authority, association or other entity.
1.89 “Phase III Clinical Trial” means a human clinical trial in any country that would satisfy the requirements of 21 CFR 312.21(c).
1.90 “Platform Technology” means (a) the Codexis Core Technology, (b) the Codexis Enzymes, and (c) the Codexis Libraries, and in each case, which are provided to Merck by Codexis under this Agreement.
1.91 “Process Technology” means any method, process, or other invention pertaining to the use of any Covered Enzyme or Enzyme; provided that Process Technology shall exclude Technology that is generally applicable to chemical process development and to the synthesis and scale up of compounds and that does not specifically require the use or performance of an enzyme, Covered Enzyme, or Enzyme.
1.92 “Project Enzyme” means any Enzyme derived from an Initial Enzyme arising from a Round of Enzyme Evolution.
1.93 “Prosecution” means the preparation, drafting, filing, prosecution (including any interferences, reissue proceedings, reexaminations, inter partes reviews, post-grant reviews, oppositions and Patent office appeals) and maintenance of Patents in the Territory. When used as a verb, “Prosecute” means to engage in Prosecution.
1.94 “Regulatory Approval(s)” means, with respect to any Therapeutic Product in any jurisdiction, all approvals from any Regulatory Authority necessary for the commercial manufacture, marketing and sale of any product containing such Therapeutic Product in such
jurisdiction in accordance with Applicable Law, including without limitation, receipt of pricing and reimbursement approvals, where required.
1.95 “Regulatory Authority” means any national or supranational governmental authority, including without limitation, the FDA, which has responsibility in countries in the Territory over the development and/or commercialization of any Therapeutic Product, as applicable.
1.96 “Regulatory Filings” means any and all regulatory applications, filings, approvals and associated correspondence required to develop any Therapeutic Product in each country or jurisdiction in the Territory.
1.97 “Restricted Enzyme” means any enzyme, or any vector that encodes for any such enzyme, listed in Exhibit 1.97. During the Term, Exhibit 1.97 may be revised in accordance with Section 3.6.
1.98 “ROFR Period” means, with respect to a given Merck Developed API, the period beginning on completion of a [***]
[***] and ending on the [***].
1.99 “Round(s) of Enzyme Evolution” means round of Initial Enzyme Optimization conducted during a Technology Transfer Project resulting in Project Enzymes.
1.100 “Sitagliptin Agreement” means that certain Sitagliptin Catalyst Supply Agreement entered into by and between the Parties and effected as of February 1, 2012.
1.101 “Technology” means Know-How, Inventions, industrial designs, works of authorship, development tools, files, records and data, all emulation and simulation tools and reports, prototypes, sequences, structures, databases and data collections, and all tangible embodiments of the foregoing, provided, however, Technology shall not include Codexis Software (or software, source code, object code, graphical user interfaces, application programming interfaces, programs, objects, modules, algorithms, routines or firmware used or utilized in Codexis Software).
1.102 “Technology Transfer” means (a) the transfer to Merck of the Platform Technology, Codexis Documentation, Codexis Software, Codexis Materials, and Improvements thereto which come to be Controlled by Codexis during the TT Term (and, if Merck exercises an Option, during that portion of the Improvements TT Term for which the exercised Option applies), and (b) the training provided to Merck with respect to the Platform Technology, in each case to be conducted in accordance with the Technology Transfer Plan and Article 2.
1.103 “Technology Transfer Plan” means that plan for the Technology Transfer as mutually agreed between the Parties and set forth in Exhibit 1.103 as of the Effective Date and as may be amended by the Parties during the TT Term in accordance with Section 2.2.2 itemizing each Party’s responsibilities and obligations, the activities to be performed by each Party, and a timeline for performance of such activities, in connection with the Technology Transfer from Codexis to Merck to fully implement the Platform Technology at the Designated Lab.
1.104 “Technology Transfer Project” means any Enzyme evolution project that was initiated using an Initial Enzyme during the TT Term.
1.105 “Territory” means all of the countries in the world, and their territories and possessions.
1.106 “Therapeutic” means a compound, molecule, pharmaceutical, drug, biological preparation, or other product for the treatment or prevention of any disease or medically treatable or preventable condition.
1.107 “Therapeutic Enzyme” means [***].
1.108 “Therapeutic Product” means any Therapeutic owned or Controlled by Merck or its Affiliates (or their permitted licensees, successors, assigns and transferees) containing a Merck Developed API.
1.109 “Third Party” means any Person other than Merck and Affiliates of Merck, and Codexis and Affiliates of Codexis.
1.110 “TT Term” means the period beginning on the Effective Date and ending on the TT Term Expiration Date.
1.111 “TT Term Expiration Date” means the earlier of (a) the date of satisfactory completion of the Technology Transfer (in accordance with Section 2.2.7), or (b) the later to occur of fifteen (15) months following the Effective Date or such later date as determined pursuant to Section 2.2.7.
1.112 “United States” or “U.S.” means the United States of America and all its territories and possessions.
1.113 “Vaccine” means [***].
1.114 “[***]” means that either [***].
1.115 “Wave” means each phase of the Technology Transfer noted as Wave 1 and Wave 2 of the Technology Transfer Plan in force as of the Effective Date, and from time-to-time during the TT Term.
2. TECHNOLOGY TRANSFER
2.1 Management of Technology Transfer.
2.1.1 Scientific Lead. Each Party shall designate in writing within fifteen (15) days after the Effective Date, a “Scientific Lead” with all necessary scientific skill and expertise to fulfil such role in accordance with this Article 2, to be the primary contact for such Party responsible for managing day-to-day communications between the Parties with respect to the technical aspects of the Technology Transfer and other scientific and technical activities (including any Additional Services) set forth in this Agreement, including responsibility for scheduling teleconferences and coordinating meetings and technical support as required hereunder. Each Party may respectively appoint a substitute Scientific Lead to represent it under this Section 2.1.1.
2.1.2 Alliance Manager. Each Party shall designate in writing within fifteen (15) days after the Effective Date, an “Alliance Manager” with all necessary business skill and expertise as necessary to be the primary contact for such Party as regards all business development and/or contract-related communications between the Parties for all matters in connection with this Agreement, outside of the purview of the technical matters for which the Scientific Leads are responsible. The Alliance Managers shall be responsible for initially addressing any finance, legal and business issues that may arise. Each Party may respectively appoint a substitute Alliance Manager to represent it under this Section 2.1.2.
2.1.3 Limitations. The Scientific Leads and the Alliance Managers shall not have the authority to amend, modify or waive compliance with this Agreement, through meeting minutes, e-mails or otherwise.
2.2 Technology Transfer.
2.2.1 Technology Transfer Plan. The Parties shall perform the Technology Transfer in Waves during the TT Term pursuant to the timelines and in accordance with the responsibilities allocated under the Technology Transfer Plan. Each Party shall perform the activities assigned to such Party under the Technology Transfer Plan at the sites identified in Section 2.2.6 and shall perform all such activities in compliance with Applicable Law. Each Party shall be responsible for all salaries and costs and expenses of their own personnel (including, without limitation, travel and living expenses). Without limiting the foregoing, Codexis shall provide Merck
the Codexis Methods at dates no later than those set forth in the timelines in the Technology Transfer Plan. Codexis shall promptly transfer to Merck (a) the Initial Technology Transfer Inventory, (b) the Codexis Materials, (c) the Codexis Documentation, and (d) the Codexis Software and other Platform Technology, at dates no later than those set forth in the timelines in Technology Transfer Plan. All Technology Transfer activities shall be performed [***] by the Parties. Notwithstanding anything to the contrary, subject to any updates to the Technology Transfer Plan pursuant to Section 2.2.2, Codexis shall not be obligated to transfer to Merck any information and/or materials not described in the Technology Transfer Plan.
2.2.2 Updates to Technology Transfer Plan. In the event that errors and/or omissions in the Technology Transfer Plan are discovered by Merck and/or Codexis during the TT Term and the Parties agree to update the Technology Transfer Plan pursuant to any reasonable scientific rationale agreed between the Parties to enable Merck to practice the Platform Technology, the Parties shall then update the Technology Transfer Plan accordingly.
2.2.3 Improvements Arising During TT Term. Within [***] after the end of the Calendar Quarters ending June 30 and December 31, Codexis will disclose to Merck any and all Improvements relating to the Platform Technology which have come to be Controlled by Codexis at any time during the TT Term, and which have been identified and are being practiced by Codexis in its own business operations, including, without limitation, all Codexis Core Technology Improvements (including any and all Improvements to the Codexis Methods, the Initial Technology Transfer Inventory and the Codexis Software), Improvements to the Codexis Materials and the Codexis Documentation, Arising Codexis Enzyme Technology, and/or Arising Codexis Process Technology which come to be Controlled by Codexis during the TT Term. [***]
2.2.4 Technology Transfer Teams. In order to effect Section 2.2:
(a) Merck shall identify a Technology Transfer team of personnel and in such numbers as it may so determine (the “Merck Team”) to participate in the Technology Transfer. Merck may change any member(s) of the Merck Team in its sole discretion at any time. The Merck Team shall have all reasonable skills and experience in the field of protein engineering to perform the Technology Transfer. [***]. [***], Merck shall remain at all times fully liable for its respective responsibilities with respect to the Technology Transfer.
(b) Codexis shall identify a Technology Transfer team to lead the Merck Team in the Technology Transfer (the “Codexis Team”) as detailed in the Technical Transfer Plan. Codexis, in its sole discretion, may change any member(s) of the Codexis Team at any time. Each member of the Codexis Team shall have all necessary scientific experience and expertise
to perform the Technology Transfer in accordance with the Technology Transfer Plan. [***]. [***], Codexis shall remain at all times fully liable for its respective responsibilities with respect to the Technology Transfer.
2.2.5 Wave 1 of Technology Transfer Plan. After the Effective Date, the Codexis Team will transfer Codexis screening capabilities to Merck as outlined in the Technology Transfer Plan. Wave 1 will be deemed complete upon Completion of Wave 1.
2.2.6 Wave 2 of Technology Transfer Plan. On an agreed-upon date, the Codexis Team and the Merck Team will participate in Wave 2 of Technology Transfer activities by enabling Merck to practice the Platform Technology at the Designated Lab. As part of Wave 2, Codexis and Merck shall participate in Technology Transfer Project 1 at Codexis’ facility in Redwood City, California and Technology Transfer Project 2 at the Designated Lab. Each of Merck and Codexis shall bear its own costs and expenses of providing such training. Wave 2 will be deemed complete upon Completion of Wave 2.
2.2.7 Completion of Technology Transfer. The Technology Transfer will be deemed complete upon the Completion of Wave 1 and the Completion of Wave 2. If the Completion of Wave 1 does not occur within [***] from the Effective Date and/or the Completion of Wave 2 does not occur by the TT Term Expiration Date, and the delay in the Completion of Wave 1 and/or the Completion of Wave 2 is proximately caused by decision(s), action(s) or inaction(s) of Merck, its Affiliates and/or Third Parties controlled by Merck and/or its Affiliates, then the TT Term Expiration Date shall be extended by the period of time equal to the delay in the Completion of Wave 1 and/or the Completion of Wave 2 which is proximately caused by such decision(s), action(s) and/or inaction(s) of Merck, its Affiliates and/or Third Parties controlled by Merck or its Affiliates, provided, however, in no event will the TT Term Expiration Date be extended pursuant to this Section 2.2.7 beyond [***] from the Effective Date where any such extension is proximately caused by decision(s), action(s) or inaction(s) of Merck, its Affiliates and/or Third Parties controlled by Merck and/or its Affiliates. If Completion of Wave 1 and/or the Completion of Wave 2 are not achieved on or before [***] from the Effective Date where such non-achievement is proximately caused by decision(s), action(s) or inaction(s) of Merck, its Affiliates and/or Third Parties controlled by Merck and/or its Affiliates, the applicable milestone payment(s) set forth in Section 7.3 shall be paid to Codexis in the manner set forth in Section 7.3. In the event either Party reasonably disputes whether or not the Completion of Wave 1 and/or the Completion of Wave 2 have occurred, the Parties will submit such dispute for resolution in accordance with Article 13.
2.3 Transfers of Materials. In the event that the Parties mutually agree that a transfer of any biopharmaceutical, biological, chemical or other like material (“Material(s)”) from
one Party to the other Party is necessary or desirable to facilitate the Parties’ collaborative activities pursuant to this Agreement then, except (i) where Codexis Materials are transferred by Codexis to Merck pursuant to the Technology Transfer Plan (which in all cases shall be itemized and recorded in writing, such written records to be sent to Merck for confirmation of receipt of all such items), or (ii) where Materials are transferred by Codexis to Merck and are identified as a “deliverable” under a Statement of Work, such Materials will be transferred subject to and in accordance with a material transfer agreement in a form satisfactory to both Parties.
2.4 Designated Lab. Merck shall be responsible for providing space for the Designated Lab, procuring all equipment necessary for operation of the Designated Lab, designing the Designated Lab, and constructing the Designated Lab.
3. LICENSES
3.1 Licenses to Codexis.
3.1.1 Merck Background IP License. Subject to the terms and conditions of this Agreement, Merck hereby grants to Codexis, during the Term, a worldwide, non-exclusive, non-transferable (except as provided in Section 14.8), fully paid-up, royalty-free right and license, with the right to grant sublicenses solely to Affiliates, under Merck’s Background IP in the Merck Exclusive Field and Merck Non-Exclusive Field solely as necessary for Codexis to perform its obligations during the Technology Transfer and under each Technology Transfer Project as set forth in the written research plan applicable to such Technology Transfer Project and for any Additional Services.
3.1.2 Arising Merck Enzyme Technology IP. Subject to the terms and conditions of this Agreement (including, for the avoidance of doubt, Article 12), Merck hereby grants to Codexis a worldwide, exclusive, non-transferable (except as provided in Section 14.8), fully paid-up, royalty-free right and license, with the right to grant sublicenses through multiple tiers, under the Arising Merck Enzyme Technology IP invented using the Platform Technology, solely to improve, make, have made, use, and sell Enzymes for use solely outside of the Merck Exclusive Field.
3.1.3 Arising Merck Process Technology IP. Subject to the terms and conditions of this Agreement (including, for the avoidance of doubt, Article 12), Merck hereby grants to Codexis a worldwide, non-exclusive, non-transferable (except as provided in Section 14.8), fully paid-up, royalty-free right and license, with the right to grant sublicenses through multiple tiers, under the Arising Merck Process Technology IP (excluding, in any event, any Merck API Process Technology IP) invented using the Platform Technology for any use solely outside of the Merck
Exclusive Field. During [***] and for a period of [***], Codexis covenants and agrees that, notwithstanding [***]. After the [***] period, Codexis shall [***], provided that Codexis shall [***]
3.2 Licenses to Merck.
3.2.1 Platform Technology Licenses. Subject to the terms and conditions of this Agreement (including the limitations set forth in Section 3.4), Codexis on behalf of itself and its Affiliates hereby grants to Merck, during the Term, a nontransferable (except as provided in Section 14.8), right and license, with the right to grant sublicenses to Affiliates, in accordance with, and to the extent permitted under, Section 3.3, under the Licensed IP in the Territory, with respect to enzymes, including any enzyme owned or otherwise Controlled by Merck under this Agreement or otherwise, to use in the Designated Lab the Platform Technology (or any aspect of the Platform Technology) (but excluding the Codexis Software, which shall instead be subject to the license set forth in Section 3.2.2, below), which right and license shall be:
(a) exclusive in the Merck Exclusive Field; and
(b) non-exclusive in the Merck Non-Exclusive Field;
in each of Sections 3.2.1(a) and 3.2.1(b), solely to research, develop, use, optimize, modify, isolate, engineer, identify, select, make, have made, import and/or export, Enzymes, other than any Restricted Enzyme.
3.2.2 License to Codexis Software. Subject to the terms and conditions of this Agreement (including the limitations set forth in Section 3.4), Codexis on behalf of itself and its Affiliates hereby grants to Merck, during the Term, a nontransferable (except as provided in Section 14.8), right and license, sublicensable to Affiliates in accordance with, and to the extent permitted under, Section 3.3), to (i) deploy [***] the Codexis Software on Approved Servers, and (ii) access and use [***] the Codexis Software solely from the Designated Lab. [***] The foregoing license set forth in this Section 3.2.2 shall be:
(a) exclusive in the Merck Exclusive Field; and
(b) non-exclusive in the Merck Non-Exclusive Field;
in each of Sections 3.2.2(a) and 3.2.2(b), solely to research, develop, use, optimize, modify, isolate, engineer, identify select, make, have made, import and/or export Enzymes, other than any Restricted Enzyme.
3.2.3 Manufacturing Licenses. Subject to the terms and conditions of this Agreement (including the limitations set forth in Section 3.4), Codexis hereby on behalf of itself and its Affiliates grants to Merck, during the Term, a non-transferable (except as provided in Section 14.8) right and license, with the right to grant sublicenses to Affiliates, contract manufacturing organizations (CMOs), contract research organizations (CROs), or other contract service organizations in accordance with and to the extent permitted under Section 3.3 under the Licensed IP in the Territory, solely to make, have made, import and/or export Enzyme(s) for use in Therapeutic Product(s) or Merck Developed API(s), which right and license shall be:
(a) exclusive in the Merck Exclusive Field; and
(b) non-exclusive in the Merck Non-Exclusive Field.
3.2.4 Loss of Exclusivity. The exclusive licenses granted by Codexis to Merck in the Merck Exclusive Field pursuant to Sections 3.2.1, 3.2.2 and 3.2.3 shall become non-exclusive, on a Therapeutic-by-Therapeutic and country-by-country basis, on the first date that both (i) [***], and (ii) [***].
3.3 Sublicensing. To the extent that either Party is permitted to grant sublicenses under the licenses granted to it under this Agreement, either Party shall have the right to grant such sublicenses through multiple tiers of sublicensees; provided that:
3.3.1 any sublicense agreement between Merck and a Third Party sublicensee relating to the performance of Merck’s obligations or exercise of Merck’s rights under this Agreement shall include material transfer terms, and non-use and non-disclosure confidentiality terms, that are no less stringent than terms used by Merck in the ordinary course of Merck’s business in similar transactions involving Merck’s proprietary materials and information of a similar nature;
3.3.2 any such sublicense is consistent with and subject to the terms of this Agreement and shall terminate automatically upon termination of the corresponding license hereunder;
3.3.3 each Party, within thirty (30) days after the effective date of any sublicense, shall provide written notice to the other Party of the grant, the date, and the identity of the Third Party of any sublicense to a Third Party;
3.3.4 each Party shall not be relieved of its obligations pursuant to this Agreement as a result of such sublicense ; and
3.3.5 any sublicense granted by Merck shall (a) prohibit the sublicensee from using the Platform Technology for any purpose other than as specified in Section 3.2.1, Section 3.2.2 and Section 3.2.3 and (b) require the sublicensee to destroy all Platform Technology, and all Information of Codexis, in possession of such sublicensee after completion of the sublicensee’s obligations under such sublicense.
3.4 Limitations on Licenses.
3.4.1 In-Licensed Patents. With respect to any aspect of the In-Licensed Patents for which Codexis has less than fully exclusive, worldwide rights (e.g., co-exclusive, non-exclusive, limited territorial or otherwise restricted rights), the licenses provided in Sections 3.2.1, 3.2.2, 3.2.3 and 3.5.6 shall be limited to the scope of those rights that Codexis Controls.
3.4.2 Codexis Mayflower Patents. The licenses provided in Sections 3.2.1, 3.2.2, 3.2.3 and 3.5.6 shall be limited as set forth in Exhibit 3.4.2.
3.4.3 No Use for Third Parties.
(a) Merck shall not use, and shall cause its Affiliates and permitted sublicensees not to use, the Platform Technology to engineer, synthesize, manufacture or otherwise develop or produce any Enzymes, molecules, biologic agents, drug products, therapeutic agents or any other compounds for or on behalf of any Third Party and/or to that Third Party’s order or direction. [***] if Merck or any Affiliate [***] and Merck or such Affiliate, [***] then Merck and/or its Affiliate may, [***]
[***]
(b) Merck shall not use, and shall cause its Affiliates and permitted sublicenses not to use, the Platform Technology to make or have made and sell, offer for sale, lease, barter, donate or otherwise transfer any enzymes or Enzymes to any Third Party. [***] if Merck or any Affiliate [***] and Merck or such Affiliate, [***] then (a) Merck or its Affiliates [***] and (b) Merck may [***].
(c) Merck shall [***].
3.4.4 Enzyme Supplier. During the Term, [***] would supply to Merck or its Affiliates or permitted sublicensees any Enzymes developed using rights licensed by Codexis to Merck under the terms of this Agreement, [***].
3.4.5 Codexis Software Restrictions. Codexis retains ownership of all Codexis Software and rights therein and Merck will maintain the copyright notice and any other notices that appear on the Codexis Software on any copies and any media. Merck will not (and will not allow any Affiliate or Third Party to) [***]
[***]. Prior to disposing of any media or apparatus containing any part of the Codexis Software, Merck shall completely destroy any Codexis Software contained therein. All the limitations and restrictions on Codexis Software in this Agreement shall also apply to any Codexis Documentation for the Codexis Software. Merck acknowledges and agrees that it will be solely responsible for providing, maintaining, and supporting the Approved Servers.
3.5 Options to Improvements Arising After TT Term.
3.5.1 Option Grants. Subject to the terms and conditions of this Agreement, Codexis hereby grants to Merck [***] annual options, exercisable within the Improvements TT Term and [***] thereafter at Merck’s sole discretion in accordance with Section 3.5.2, to acquire the rights described in Section 3.5.3, which options shall be exclusive as to the Merck Exclusive Field and non-exclusive in the Merck Non-Exclusive Field (each, an “Option”).
3.5.2 Initial Disclosure. Within [***] following each Option Year, Codexis will discuss with Merck any Option Improvements which have come to be Controlled by Codexis during the applicable Option Year and which have been identified and are being practiced by Codexis in its own business operations, and will describe all such Option Improvements to Merck in sufficient detail to assist Merck in determining whether to exercise an Option with respect to such Option Improvements. Merck shall have [***] after receipt of the initial disclosure regarding such Option Improvements to request the disclosure of further information Controlled by Codexis with respect to such Option Improvements (“Option Evaluation Request”). All such disclosures, whether initial or subsequent, shall be considered the Information of Codexis.
3.5.3 Option Exercise. Merck shall have [***] after receipt of the initial disclosure or, if an Option Evaluation Request is timely made, [***] from the date of Codexis’ further disclosure of information disclosure pursuant to the Option Evaluation Request, to request in writing that Codexis disclose and license the Option Improvements to Merck (“Option Election Date”). If Merck timely exercises an Option, then Merck shall, within [***] of the Option Election Date, pay to
Codexis the sum of [***] for the Option elected and Codexis will promptly disclose to Merck any and all Option Improvements subject to such Option and such Option Improvements shall be deemed licensed to Merck under Section 3.5.6.
3.5.4 [***] Exercise of Option. Merck will be [***].
For example, if Merck [***]
[***]
3.5.5 Role of Scientific Lead. During the Improvements TT Term and for [***] thereafter, if Merck exercises an Option with respect to any Option Improvements, Codexis shall make its Scientific Lead reasonably available to provide telephonic or web-based advisory technical support and assistance to Merck in Merck’s practice of the Platform Technology and such Option Improvements.
3.5.6 Grant of Rights. Subject to the terms and conditions of this Agreement (including the limitations set forth in Sections 3.2, 3.3 and 3.4), effective immediately upon Merck’s exercise of an Option in accordance with Section 3.5.3, Codexis hereby on behalf of itself and its Affiliates grants to Merck a worldwide, non-transferrable (except as permitted under Section 14.8), non-sublicensable (except as permitted in accordance with Sections 3.2.1, 3.2.2 and 3.2.3) license, which license shall be either exclusive, non-exclusive or both as determined in accordance with Sections 3.2.1, 3.2.2 and 3.2.3, under all of Codexis’ right to Codexis Core Technology Improvements IP practiced by Codexis during the Option Year for which the Option is exercised (pursuant to Section 3.5.3) or [***] exercised (pursuant to Section 3.5.4). Codexis shall provide any technology transfer or scientific or technical resources reasonably requested by Merck, and reasonably necessary for Merck, to practice such Codexis Core Technology Improvements IP, at Merck’s reasonable expense. During the Improvements TT Term, Codexis’ Alliance Manager will periodically disclose to Merck’s Alliance Manager information regarding new, updated or improved Enzyme kits or panels (as defined in this Section 3.5.6 below). For purposes of this Section 3.5.6, the term “new, updated or improved Enzyme kits or panels” means a collection of multiple, genetically-diverse Enzymes, Controlled by Codexis, that are first made commercially available to the general public by Codexis through Codexis’ catalog or website. All information, documents and other materials provided by Codexis to Merck pursuant to this Section 3.5.6 shall constitute Information of Codexis.
3.5.7 Extension of the Improvements TT Term. Upon mutual written agreement of the Parties, and payment by Merck to Codexis of an amount to be mutually agreed in
good faith by the Parties, within the sixty (60) day period prior to the then-current Improvements TT Term Expiration Date, the Improvements TT Term Expiration Date may be extended by one (1) year. The Parties may extend the Improvements TT Term Expiration Date any number of times in accordance with this Section 3.5.7.
3.6 Restricted Enzymes.
3.6.1 During the Term, in its ordinary course of business, Codexis will conduct research and development activities for itself and Third Parties under the Licensed IP using the Platform Technology and, in connection with such research and development activities, will generate Potentially Restricted Enzymes that, in certain cases, on a Potential Restricted Enzyme-by-Potentially restricted Enzyme basis, (a) will be owned in whole or in part by such Third Parties or exclusively licensed in whole or in part by Codexis to such Third Parties, (b) will not be Controlled by Codexis, or (c) Codexis otherwise has a reasonable basis to designate as a Potentially Restricted Enzyme. For purposes of this Section 3.6.1, the term “Potentially Restricted Enzyme” means any enzyme, or any vector that encodes for enzyme, derived from the use of the Platform Technology by Codexis after the Effective Date that, in either case, may not be Controlled by Codexis or is an enzyme that Codexis has a reasonable basis to designate as a Potentially Restricted Enzyme. In the event that any Potentially Restricted Enzyme generated by Codexis is not Controlled by Codexis or is an enzyme that Codexis has a reasonable basis to designate as a Potentially Restricted Enzyme, Codexis, subject to confidentiality obligations owed by Codexis to any Third Party, will inform the Patent Committee of such Potentially Restricted Enzyme at its next regularly scheduled meeting and amend the list of Restricted Enzymes set forth in Exhibit 1.97 to include the Potentially Restricted Enzyme. The Patent Committee will review information provided by Codexis with respect to any such Potentially Restricted Enzyme and, in accordance with Section 5.5.3, determine whether the list of Restricted Enzymes set forth on Exhibit 1.97 shall be revised to include such Potentially Restricted Enzyme and, if applicable, any particular field(s) and/or use(s) restrictions with respect to such Potentially Restricted Enzyme. The Patent Committee will create and maintain a list of all Potentially Restricted Enzymes.
3.6.2 In the event that Merck wishes to exercise its rights under Section 3.6.1 to any Restricted Enzyme for any specific field(s) and/or use(s), it shall notify Codexis in writing of such request. Codexis shall then have [***] in which to confirm to Merck in writing whether Codexis Controls such Restricted Enzyme for such specific field(s) and/or use(s) requested by Merck. In the event that Codexis does Control such Restricted Enzyme for such specific field(s) and/or use(s) then effective upon the date of such written confirmation from Codexis, such Restricted Enzyme shall be an Enzyme for such specific field(s) or use(s) for the purpose of Section 3.2. [***]
3.7 Merck Developed Improvements. During the Term, within [***] after the end of the Calendar Quarters ending June 30 and December 31, Merck’s representative on the Patent Committee will meet and discuss with Codexis’ representative on the Patent Committee any Codexis Core Technology Improvements, Merck Core Technology Improvements, Arising Merck Enzyme Technology, and Arising Merck Process Technology (other than any Merck API Process Technology) which Merck has developed since the last such meeting. Codexis shall have [***] after such meeting and receipt of the initial disclosure regarding such Codexis Core Technology Improvements, Merck Core Technology Improvements, Arising Merck Enzyme Technology, and Arising Merck Process Technology to request the disclosure of further information and Technology which is Controlled by Merck. Any disclosures or transfers of Technology from Merck to Codexis under this Section 3.7 shall be at Codexis’ sole expense.
3.8 Public Domain Information and Material. Codexis acknowledges and agrees that Merck shall be free to utilize, without restriction, any information, material, or other Technology that is (a) within the Platform Technology (including any Improvements thereto) and (b) wholly within the public domain.
3.9 No Implied Licenses. No license or other right is or shall be created or granted hereunder by implication, estoppel or otherwise. All licenses and rights are or shall be granted only as expressly provided in this Agreement. All rights not expressly granted by a Party under this Agreement are reserved by such Party and may be used by such Party for any purpose. For clarity, there shall be no implied license or implied other right in favor of Codexis to any Enzyme, and there shall be no implied license or implied other right in favor of Merck to any Technology or Intellectual Property Rights of Codexis that is not expressly addressed in this Agreement.
4. SERVICES
4.1 Evolution Programs. In addition to, and not in lieu of, the Technology Transfer, Codexis shall provide to Merck, [***] into the data and decision matrix/process of Codexis for [***] evolution programs dedicated to Merck during the fifteen (15) month period commencing with the Effective Date at Codexis’ facility in Redwood City, California (each an “Evolution Program”). [***] Codexis’ only obligation with respect to Evolution Program(s) is to perform such Evolution Program(s) in good faith and to provide services of its personnel. Codexis makes no warranty that the Evolution Programs will result in any level of success. All Evolution Programs will conclude, if not earlier completed, on the date which is fifteen (15) months after the Effective Date. At any time during this fifteen (15) month period, [***]. Merck and Codexis previously entered into that certain [***] and [***] (each an “Existing [***]” and collectively the “Existing [***]”). Should Merck
decide to transfer the subject of work from an Existing [***] to either (a) a Technology Transfer Project or (b) an Evolution Program, then from the date such transfer becomes effective the terms and conditions of this Agreement shall apply to such work in substitution for the terms and conditions of the Existing [***].
4.2 Additional Services. At any time during the Term, Codexis and Merck may mutually agree for Codexis to perform additional enzyme evolution related services for the benefit of Merck, with the scope, deliverables, fees, and conduct of the Parties with respect to such additional services to be set forth in a mutually agreeable statement of work (each, a “Statement of Work”) in a form substantially similar to that attached as Exhibit 4.2. All Additional Services, and the performance thereof by Codexis, will be subject to the terms and conditions of this Agreement. All Additional Services shall be performed [***] by Codexis. Without limiting the foregoing, Codexis will [***] to accomplish the Additional Services in accordance with any applicable Statement of Work and the terms of this Agreement.
4.3 Subcontracting. Subject to Merck’s compliance with Section 3.3 and Codexis’ prior written consent, such consent not to be unreasonably withheld, conditioned or delayed, Merck may perform any of its obligations or exercise any of its rights under this Agreement through one or more Third Party contractors, contract manufacturing organizations (CMOs), contract research organizations (CROs) or other contract service organizations, provided, however, Merck may not subcontract any activities to a Third Party that would permit such a Third Party to receive and/or use the Platform Technology. Subject to Codexis’ compliance with Section 3.3, and Merck’s prior written consent, such consent not to be unreasonably withheld, conditioned or delayed, Codexis may perform any of its obligations under Technology Transfer Project 1 (as described in the Technology Transfer Plan) and Technology Transfer Project 2 (as described in the Technology Transfer Plan) and Article 4 through one or more Third Party contractors, contract service organizations and academic or government collaborators; provided that the activities corresponding to such obligations [***]. Merck hereby approves the use by Codexis of the subcontractors set forth on Exhibit 4.3.
5. JOINT STEERING COMMITTEE; PATENT COMMITTEE.
5.1 Joint Steering Committee Establishment. Within thirty (30) days after the Effective Date, the Parties shall establish a joint steering committee (the “Joint Steering Committee” or “JSC”) to have overall responsibility for managing and directing the Technology Transfer and Additional Services and to oversee and make certain decisions regarding the Technology Transfer and the Additional Services. The JSC shall also provide a forum for sharing advice, progress and results relating to the activities conducted by the Parties and shall attempt to facilitate the resolution of any disputes between the Parties. At each meeting of the JSC, each Party shall brief the JSC regarding the content, execution and results achieved by such Party with respect to the Technology Transfer and Additional Services. Each Party, through its representatives on the JSC, shall be permitted to provide advice and commentary with respect to the Technology Transfer and Additional Services. The JSC shall have the following specific responsibilities:
5.1.1 oversee, review and provide advice regarding the overall progress of the Technology Transfer and any Additional Services;
5.1.2 coordinate by way of each Party’s Scientific Leads the research activities under a written research plan relating to a Technology Transfer Project agreed by the Parties and coordinate sharing of results and data arising therefrom;
5.1.3 appoint and oversee subcommittees as it deems appropriate for carrying out activities under this Agreement, including for oversight of any specific aspects of any portion of the Technology Transfer, Additional Services, or other matters;
5.1.4 review the Technology Transfer Plan and any Statements of Work and, if appropriate, propose modifications thereto to the Parties; and
5.1.5 perform any other activities or functions as the Parties may mutually agree in writing.
5.2 Membership; Meetings. The JSC shall be composed of two (2) employees from each of Merck and Codexis and shall meet, in person, by teleconference, or by video-teleconference, at least one (1) time per Calendar Quarter, or more or less often as the Parties shall determine; provided that nothing under this Agreement shall prevent the Parties from meeting in person, by teleconference, or by video-teleconference more frequently as may be mutually agreed by the JSC representatives. In-person meetings shall alternate between Codexis and Merck locations within the United States whenever possible unless otherwise agreed by the Parties. The first such meeting shall be within forty-five (45) days after the Effective Date. Any member of the JSC may
designate a substitute, who shall be an employee of the applicable Party, to attend with prior written notice to the other Party. Ad hoc guests who are subject to written confidentiality obligations at least as stringent as the provisions in Article 10 may be invited to JSC meetings. Each Party may replace its JSC members with other of its employees, at any time, upon written notice to the other Party.
5.3 Decision-Making; Limitations on JSC. Decisions of the JSC shall be made by consensus, including issues concerning technical feasibility and the deployment of Codexis resources, with each Party having collectively one (1) vote in all decisions. The JSC shall have only such powers as are specifically delegated to it in this Agreement, and such powers shall be subject to the terms and conditions set forth herein. Without limiting the generality of the foregoing, the JSC shall have no power to amend this Agreement, the Technology Transfer Plan, or any Statement of Work. The Parties shall be alternately responsible for preparing and circulating minutes, for approval by the non-preparing Party, within fourteen (14) days after each meeting including but not limited to a list of topics of discussion at the meeting and a list of any actions, decisions or determinations approved and a list of any issues and actions to be resolved. If the JSC is unable to reach a consensus decision on a matter that is within its decision-making authority within thirty (30) days after it has met and attempted to reach such decision, then such matter shall be resolved in accordance with Article 13. Any matter not expressly provided for hereunder and any matter relating to any Merck Background IP, Merck Developed API, Therapeutic Products, Platform Technology (other than certain Improvements with respect thereto), Licensed IP (other than certain Improvements with respect thereto), or Codexis Background IP (other than certain Improvements with respect thereto) shall remain outside of the scope of the JSC.
5.4 Duration of JSC. The JSC shall be automatically disbanded upon the TT Term Expiration or the earlier termination of this Agreement; provided that the Parties may, by mutual written agreement, extend the term of the JSC for additional one (1) year periods after the expiration of the TT Term with a separate mutual written agreement required for each such one (1) year extension.
5.5 Patent Committee
5.5.1 Establishment. Within sixty (60) days after the Effective Date, the Parties shall establish a Patent committee (the “Patent Committee”) to discuss, oversee and coordinate the Prosecution (or abandonment) of Patents, enforcement of Patents, and defense against claims of infringement of Third Party patents relating to Intellectual Property licensed under Article 3, Sections 2.2.3, 3.5 and 3.7, including for example Codexis Core Technology Improvements IP, Arising Codexis Enzyme Technology IP, Arising Codexis Process Technology IP, Arising Merck Enzyme Technology IP and Arising Merck Process Technology IP, and any related Intellectual
Property matters regarding any Inventions made during the Term, including for example, the Licensed Additional Codexis Patents and the Licensed Additional Codexis Know-How; and to provide recommendations to the Parties regarding the Prosecution of such Patents and related Intellectual Property matters. Within thirty (30) days after the end of each half year, each Party shall provide the Patent Committee with a report listing all Patents relating to such Parties’ utilization of the Platform Technology filed by that Party during that half year.
5.5.2 Membership; Meetings. The Patent Committee shall be composed of one (1) employee from each of Merck and Codexis knowledgeable in U.S. patent law and the technology areas that are the subject of this Agreement. The Patent Committee shall meet, in person, by teleconference, or by video-teleconference, at least one (1) time per Calendar Quarter, or more or less often as the Parties shall determine. In-person meetings shall alternate between Codexis and Merck locations within the United States whenever possible unless otherwise agreed by the Parties. The first such meeting shall be within ninety (90) days after the Effective Date. Any member of the Patent Committee may designate a substitute, who shall be an employee of the applicable Party, to attend with prior written notice to the other Party. Ad hoc guests who are subject to written confidentiality obligations at least as stringent as the provisions in Article 10 may be invited to Patent Committee meetings. Each Party may replace its Patent Committee members with other of its employees with the qualifications set forth in this Section 5.5.2, at any time, upon written notice to the other Party.
5.5.3 Decision-Making; Limitations on Patent Committee. Decisions of the Patent Committee shall be made by consensus, with each Party having collectively one (1) vote in all decisions. The Patent Committee shall have only such powers as are specifically delegated to it in this Agreement and such powers shall be subject to the terms and conditions set forth herein. Without limiting the generality of the foregoing, the Patent Committee shall have no power to amend this Agreement, the Technology Transfer Plan or any written research plan. If the Patent Committee is unable to reach a consensus decision on a matter that is within its decision-making authority within thirty (30) days after it has met and attempted to reach such decision, then either Party may refer such matter for resolution by the executive officers designated by the Parties for attempted resolution pursuant to Section 13.1. In the event that the executive officers of each Party are unable to resolve such matter within the time period specified in Section 13.1, then Codexis shall have final decision-making authority with respect to any dispute relating specifically to Restricted Enzymes and Codexis Patents and Merck shall have final decision-making authority with respect to any dispute relating specifically to Merck Patents. The Patent Committee shall provide status updates to the JSC once per Calendar Quarter as long as the JSC is in existence and, thereafter, to the Parties.
5.5.4 Duration of Patent Committee. The Patent Committee shall endure for the Term and, by mutual agreement, beyond the Term.
6. INTELLECTUAL PROPERTY
6.1 Background Rights. Each Party shall retain all right, title and interest to its Background IP, and, except as expressly set forth in this Agreement, no right or license to Patents or other Intellectual Property Rights is granted by either Party to the other Party.
6.2 Inventorship; Ownership of Technology.
6.2.1 Generally. Inventorship of Inventions and ownership of any other Technology shall be determined by Applicable Law. Subject to and except as set forth in Sections 6.2.2 through 6.2.9, all patentable Inventions invented solely by or on behalf of either Party or jointly by or on behalf of both Parties under this Agreement, and all Intellectual Property Rights therein, shall be owned in accordance with inventorship.
6.2.2 Codexis Core Technology Improvements IP. Codexis shall own any and all Codexis Core Technology Improvements and Codexis Core Technology Improvements IP. Merck hereby assigns to Codexis all of Merck’s right, title and interest in and to the Codexis Core Technology Improvements IP.
6.2.3 Arising Codexis Enzyme Technology IP. Codexis shall own any and all Arising Codexis Enzyme Technology and Arising Codexis Enzyme Technology IP. Merck hereby assigns to Codexis all of Merck’s right, title and interest in and to the Arising Codexis Enzyme Technology IP.
6.2.4 Arising Merck Enzyme Technology IP. Merck shall own any and all Arising Merck Enzyme Technology and Arising Merck Enzyme Technology IP. Codexis hereby assigns to Merck all of Codexis’ right, title and interest in and to the Arising Merck Enzyme Technology IP.
6.2.5 Arising Codexis Process Technology IP. Codexis shall own any and all Arising Codexis Process Technology and Arising Codexis Process Technology IP. Merck hereby assigns to Codexis all of Merck’s right, title and interest in and to the Arising Codexis Process Technology IP.
6.2.6 Arising Merck Process Technology IP. Merck shall own any and all Arising Merck Process Technology and Arising Merck Process Technology IP. Codexis hereby
assigns to Merck all of Codexis’ right, title and interest in and to the Arising Merck Process Technology IP.
6.2.7 Merck API Process Technology IP. Merck shall own any and all Merck API Process Technology and Merck API Process Technology IP. Codexis hereby assigns to Merck all of Codexis’ right, title and interest in and to the Merck API Process Technology IP.
6.2.8 Merck Core Technology Improvements IP. Codexis shall own any and all Merck Core Technology Improvements and Merck Core Technology Improvements IP. Merck hereby assigns to Codexis all of Merck’s right, title and interest in and to the Merck Core Technology Improvements IP.
6.2.9 Ownership of Enzymes. As between the Parties, (i) Merck shall exclusively own all Enzymes (and any Technology and Intellectual Property Rights related thereto) derived solely from Merck’s use of the Platform Technology pursuant to this Agreement and (ii) Codexis shall exclusively own all Enzymes (and any Technology and Intellectual Property Rights related thereto) not derived solely from Merck’s use of the Platform Technology pursuant to this Agreement.
6.3 Further Assurances. Each Party and its Affiliates shall sign and deliver to the other Party all writings and do all such things as may be necessary or appropriate to vest in such other Party all right, title and interest in and to all Codexis Core Technology Improvements IP, Merck Core Technology Improvements, Arising Codexis Enzyme Technology IP, Arising Merck Process Technology IP, and Merck API Process Technology IP in accordance with Section 6.2.
6.4 Employees and Agents. Each Party shall ensure that all employees, agents, consultants, contractors and permitted subcontractors performing activities under or contemplated by this Agreement, have assigned or are obligated to assign their interest in any Invention invented in the course of such activities to the Party for which such employee, agent, consultant, contractor or subcontractor is providing its services.
6.5 Prosecution of Patents.
6.5.1 In General. The Patent Committee shall have oversight regarding the Prosecution of Patents disclosing and/or claiming Inventions directly related to Codexis Core Technology Improvements, Merck Core Technology Improvements, Arising Merck Enzyme Technology, Arising Merck Process Technology, Arising Codexis Enzyme Technology, and Arising Codexis Process Technology, and shall provide recommendations to the Parties to maximize the value of such Patents. To the extent necessary, the Parties agree to cooperate in good faith to
coordinate the Prosecution of such Patents, including submissions of Patent applications worldwide (e.g., to coordinate the filing of Patent applications to ensure that the Parties file related applications on the same day). The Parties shall agree in good faith on a strategy with respect to Prosecution of any Patents disclosing and/or claiming any jointly-owned Inventions.
6.5.2 Codexis Prosecution. As between the Parties, Codexis shall have the sole right, but not the obligation, to Prosecute all Patents disclosing and/or claiming all Codexis Core Technology, Merck Core Technology Improvements, Codexis Core Technology Improvements, Codexis Enzymes, Codexis Libraries, Arising Codexis Enzyme Technology and Arising Codexis Process Technology (the “Codexis Patents”), in Codexis’ sole discretion and at Codexis’ sole cost and expense.
6.5.3 Merck Prosecution. As between the Parties, Merck shall have the sole right, but not the obligation, to Prosecute all Patents disclosing and/or claiming all Arising Merck Enzyme Technology and Arising Merck Process Technology (collectively, the “Merck Patents”), in Merck’s sole discretion and at Merck’s sole cost and expense.
6.5.4 Back-Up Rights. If Merck decides not to Prosecute, or not to continue Prosecuting, any Merck Patents, Merck shall provide Codexis with written notice of such decision at least forty-five (45) days prior to the date upon which the subject matter of such Merck Patent shall lapse or become abandoned. The basis for such decision shall be discussed by the Patent Committee pursuant to Section 6.5.1 and Codexis shall thereupon have the right (but not the obligation) to assume responsibility for Prosecution of such Merck Patent at Codexis’ expense, and with counsel of Codexis’ choosing. Effective upon the date Codexis assumes responsibility for Prosecution of such Merck Patent, and the costs and expenses relating thereto, Merck hereby assigns any and all interest held by Merck in, to, and under such Merck Patent to Codexis.
6.5.5 CREATE Act. Each Party acknowledges and agrees that this Agreement is a “joint research agreement” as contemplated by 35 U.S.C. § 102(c), and that all inventions arising under this Agreement are intended to have the benefit of the rights and protections conferred by the Cooperative Research and Enhancement Act of 2004 (“CREATE Act”). Each Party agrees to disclose the names of both Parties in each Patent application for all inventions arising under all Technology Transfer Projects in accordance with the requirements of 35 U.S.C. § 102(c)(3).
6.6 Enforcement of Patents.
6.6.1 Notice. If either Party becomes aware of any suspected infringement of any Codexis Patent or Merck Patent, or any Codexis Patent or Merck Patent is challenged in any
action or proceeding (any of the foregoing, an “Infringement Action”), such Party shall notify the other Party’s representative on the Patent Committee, and following such notification, the Parties shall confer.
6.6.2 Enforcement. As between the Parties, Merck will have the first right, but not the obligation, to bring any Infringement Action with respect to any Merck Patent at its sole cost and expense, and Codexis shall have the sole right, but not the obligation, to bring any Infringement Action with respect to any Codexis Patent at its sole cost and expense.
6.6.3 Procedure for Enforcement.
(a) The non-enforcing Party pursuant to Section 6.6.2 shall reasonably assist the enforcing Party (at the enforcing Party’s expense) in any Infringement Action if so requested, such assistance to be coordinated through the Parties’ Patent Committee members, and the non-enforcing Party shall lend its name and be joined as a party plaintiff to such action if reasonably requested by such enforcing Party or required by Applicable Law. The non-enforcing Party shall have the right to participate and be represented in any such action by its own counsel at its own expense. The non-enforcing Party shall cooperate, at the enforcing Party’s cost and expense, with the enforcing Party in investigating or terminating any suspected infringement, whether through legal action, negotiation or otherwise, including by producing all reasonably pertinent records, papers, information, samples, specimens and similar items, and directing its employees to testify and grant interviews, upon the request of the enforcing Party. The enforcing Party will keep the non-enforcing Party reasonably informed of the status of the action through the enforcing Party’s Patent Committee members.
(b) A settlement, consent judgment or other voluntary final disposition of a suit under this Section 6.6.3 may be entered into by the enforcing Party without the consent of the non-enforcing Party; provided that any such settlement, consent judgment or other disposition of any action or proceeding by an enforcing Party under this Article 6 shall not, without the consent of the non-enforcing Party (not to be unreasonably withheld), (a) impose any liability or obligation on the non-enforcing Party, (b) include the grant of any license, covenant or other rights to any Third Party that would conflict with or reduce the scope of the subject matter included under the licenses granted to the non-enforcing Party under this Agreement, (c) conflict with or reduce the scope of the subject matter claimed in any Patent owned by the non-enforcing Party, or (d) adversely affect the interest of the non-enforcing Party in any material respect.
6.6.4 Damages. In the event that a Party exercises the rights conferred in this Section 6.6, and such Party recovers any damages or other sums in such action or in settlement
thereof, such damages or other sums recovered shall first be applied to all out-of-pocket costs and expenses incurred by the Parties in connection therewith, including attorneys’ fees. If such recovery is insufficient to cover all such costs and expenses of both Parties, it shall be shared in proportion to the total of such costs and expenses incurred by each Party. If, after such reimbursement of the Parties’ costs and expenses, any funds shall remain from such damages or other sums recovered, such remaining funds shall be retained by the prosecuting Party.
6.7 Defense Against Third Party Intellectual Property Rights.
6.7.1 Claims of Infringement Relating to Therapeutic Products or Merck Developed API. If a Third Party asserts, or either Party becomes aware of a Third Party’s intention to assert, that any Intellectual Property Rights owned or otherwise controlled by the Third Party are infringed by the manufacture, use, sale, offer for sale, import or export of a Therapeutic Product or Merck Developed API in the Territory, the Party first obtaining knowledge of such a claim shall immediately provide the other Party notice of such claim along with the related facts in reasonable detail. In such event, unless the Parties otherwise agree, as between the Parties, Merck shall have the sole right, but not the obligation, at its expense, to control the defense of such claim with respect to such Therapeutic Product or Merck Developed API, subject to Codexis’ indemnification obligations set forth in Section 11.1.2 and the obligation for Codexis to assume such defense if requested by Merck. Codexis shall cooperate with Merck in Merck’s defense of any such claim at Merck’s reasonable request and expense, and Codexis shall have the right to be represented separately by counsel of its own choice, but at its own expense. Notwithstanding anything to the contrary in this Agreement, Merck shall also control settlement of such claim; provided, however, that no settlement shall be entered into without the prior consent of Codexis, such consent not to be unreasonably withheld or delayed.
6.7.2 Claims of Infringement Relating to Licensed Rights. If a Third Party asserts, or either Party becomes aware of a Third Party’s intention to assert, that a Patent owned or otherwise controlled by the Third Party is infringed by the exercise by Merck or its Affiliates of any rights licensed to Merck hereunder (other than by the manufacture, use, sale, offer for sale, import or export of a Therapeutic Product or Merck Developed API in the Territory), the Party first obtaining knowledge of such a claim shall immediately provide the other Party notice of such claim along with the related facts in reasonable detail. In such event, unless the Parties otherwise agree, as between the Parties, Codexis shall have the sole right, but not the obligation, at its expense, to control the defense of such claim. Merck shall cooperate with Codexis in Codexis’ defense of any such claim at Codexis’ reasonable request and expense, and Merck shall have the right to be represented separately by counsel of its own choice, but at its own expense. Notwithstanding anything to the
contrary in this Agreement, Codexis shall also control settlement of such claim; provided, however, that no settlement shall be entered into without the prior consent of Merck if such settlement would adversely affect the rights and benefits of, or impose or adversely affect any obligations on, Merck, such consent not to be unreasonably withheld or delayed.
7. FINANCIAL TERMS
7.1 Upfront Payment. In consideration of the Technology Transfer and licenses granted to Merck under this Agreement, within [***] after the Effective Date, Merck shall pay to Codexis a non-creditable, non-refundable upfront payment of five million Dollars ($5,000,000).
7.2 Option Fee. Upon each exercise of an Option, as set forth in Section 3.5.3, Merck shall pay, within [***] after Merck’s receipt of an Invoice from Codexis, the non-creditable, non-refundable payment specified in Section 3.5.3.
7.3 Technology Transfer Milestones. In consideration of the Technology Transfer and licenses granted to Merck under this Agreement, Merck shall pay to Codexis, within [***] of Merck’s receipt of an Invoice from Codexis, each of the creditable, non-refundable milestone payments set forth in this Section 7.3 upon achievement of the applicable milestone event.
| | | | | |
| Technology Transfer Milestone Event | Milestone Payment |
| Completion of Wave 1 | $5,000,000.00 |
| Completion of Wave 2 | $8,000,000.00 |
7.4 Merck Developed API Payments.
7.4.1 Following Regulatory Approval of a Fee Bearing Therapeutic Product, Merck shall pay to Codexis the following amounts based on [***] of each Merck Developed API(s) manufactured using at least one (1) Enzyme by or for Merck, its Affiliates or its or their permitted licensees, successors, assignees or transferees (in accordance with Sections 3.4.3 or 14.8) for use, intended for use or usable in a Fee Bearing Therapeutic Product, on a Merck Developed API manufactured using at least one (1) Enzyme by Merck Developed API manufactured using at least one (1) Enzyme basis (“[***] Payment”):
| | | | | |
| [***] Merck Developed API manufactured using at least one (1) Enzyme | [***] Payment |
| [***] | $[***] |
| [***] | $[***] |
The event triggering the obligation of Merck to make a [***] Payment to Codexis shall be the manufacture of a Merck Developed API manufactured using at least one (1) Enzyme, notwithstanding that (i) the Merck Developed API manufactured using at least one (1) Enzyme may be placed into inventory for intended future use, (ii) Merck, its Affiliates or its or their permitted licensees, successors, assigns or transferees have not specifically identified the Merck Developed API manufactured using at least one (1) Enzyme in question as being intended for use in a particular lot of Fee Bearing Therapeutic Product, and/or (iii) Merck, its Affiliates or its or their permitted licensees, successors, assigns or transferees have not manufactured or sold the Fee Bearing Therapeutic Product. Notwithstanding the foregoing, in no event will the total, cumulative [***] Payments payable to Codexis for any Merck Developed API manufactured using at least one (1) Enzyme, regardless of the number of Therapeutic Products such Merck Developed API manufactured using at least one (1) Enzyme is used, intended for use, or usable in, exceed fifteen million Dollars ($15,000,000). For clarity, the amounts payable to Codexis based on the Merck Developed API manufactured using at least one (1) Enzyme are and shall be deemed to be unaffected by the number of Enzymes used, intended for use, or usable in the manufacture of such Merck Developed API manufactured using at least one (1) Enzyme.
7.4.2 During the Term, within [***] after the end of each Calendar Year, Merck shall deliver to Codexis a written notice identifying each (a) Fee Bearing Therapeutic Product and the Merck Developed API contained within each Fee Bearing Therapeutic Product and (b) Therapeutic Product (and the Merck Developed API contained within each such Therapeutic Product) that (i) is in active development by Merck, its Affiliates or a permitted licensee or assign and (ii) is being evaluated or has been evaluated in a Phase III Clinical Trial. During the Term, Codexis may from time to time request from Merck to confirm to Codexis whether a specific Therapeutic that (i) is in active development by Merck, its Affiliates or a permitted licensee or assign and (ii) is being evaluated or has been evaluated in a Phase III Clinical Trial is manufactured using an Enzyme, and Merck will respond in writing within a reasonable time to such written request from Codexis.
7.5 Payment Reports. Beginning after the first Regulatory Approval of a Fee Bearing Therapeutic Product, and at all times thereafter during the Term so long as Merck, its
Affiliates or its permitted licensees, successors, assignees or transferees is manufacturing a Fee Bearing Therapeutic Product, Merck shall furnish to Codexis a written report, within [***] after the end of each Calendar Quarter, showing the amount of [***] Payments due for such Calendar Quarter pursuant to Section 7.4. At the same time each payment report is issued, Merck shall issue Codexis a purchase order for the [***] Payments totaled in each payment report (itemized for each Merck Developed API). The foregoing report shall include:
(a) identification of each Fee Bearing Therapeutic Product containing a Merck Developed API and the Enzyme(s) used in such Merck Developed API;
(b) [***] of each Merck Developed API manufactured during the reporting period for use, for intended use, or usable in each Fee Bearing Therapeutic Product, as well as the cumulative total [***] of such Merck Developed API manufactured for use, intended use, or usable in each Fee Bearing Therapeutic Product;
(c) the amount payable in Dollars which shall have accrued hereunder in respect of each such [***] of Merck Developed API and the basis for calculating such amounts, as well as the cumulative total amount payable in Dollars which shall have been accrued hereunder in respect of such Merck Developed API;
(d) withholding Taxes, if any, required by Applicable Law to be deducted in respect of such amounts.
The report shall be accompanied by a copy of [***].
7.6 Manner of Payment. All Agreement Payments shall be made in Dollars by wire transfer of immediately available funds to such U.S. bank account as shall be designated by Codexis; provided, however, that any notice by Codexis of a change in such account shall not be effective until [***] after receipt thereof by Merck.
7.7 Right of First Refusal for Enzyme Supply. Subject to the limitations in this Agreement (including this Section 7.7), and solely in the event Merck or its Affiliate(s) wish to accept a bona fide offer from a specific, qualified Third Party to supply Enzymes for Merck Developed APIs, Codexis shall have a right of first refusal, solely during the ROFR Period for a specific Therapeutic Product, to [***] supply Merck and its Affiliate(s) their required quantities of Enzyme(s) for those Merck Developed API(s) that are solely for use in such Therapeutic Product(s). A “bona fide offer,” for purposes of this Section 7.7, must [***]. The foregoing right [***]. Prior to entering into any agreement with Codexis for the supply of Enzymes, and prior to obtaining supply of any Enzyme from Codexis, Merck shall [***]. If Codexis [***]. For clarity, [***]. For purposes of
clarity, nothing in this Agreement will (1) limit or abridge in any respect the rights and obligations of the Parties under the Sitagliptin Agreement, or (2) limit or restrict in any way Merck’s ability or the ability of any of Merck’s Affiliates to self-produce (whether at a Merck facility or facilities, or at a facility or facilities of any of Merck’s Affiliates) any Enzymes for Merck Developed APIs. Should Merck or its Affiliates at any time [***]
[***].
7.8 Taxes.
7.8.1 Merck will make all payments to Codexis under this Agreement without deduction or withholding for taxes, except to the extent that any such deduction or withholding is required by Applicable Law in effect at the time of payment.
7.8.2 Any tax required to be withheld on amounts payable under this Agreement shall be paid promptly by Merck on behalf of Codexis to the appropriate governmental authority, and Merck will furnish Codexis with proof of payment of such tax. Any such tax required to be withheld will be borne by Codexis.
7.8.3 Merck and Codexis will cooperate with respect to all documentation required by any taxing authority or reasonably requested by Merck to secure a reduction in the rate of applicable withholding taxes. Within [***] after the execution of this Agreement, Codexis will deliver to Merck an accurate and complete Internal Revenue Service Form W-9.
7.8.4 If Merck had a duty to withhold taxes in connection with any payment it made to Codexis under this Agreement but Merck failed to withhold, and such taxes were assessed against and paid by Merck, then Codexis will reimburse Merck for such taxes (plus interest) actually paid by Merck. If Merck makes a claim under this Section 7.8.4, it will comply with the obligations imposed by Section 7.8.2 as if Merck had withheld taxes from a payment to Codexis.
7.9 Interest Due. Without limiting any other rights or remedies available to either Party, Merck shall pay to Codexis interest on any payments that are not paid on or before the date such payments are due under this Agreement at a rate equal to the lesser of (a) [***] the 1-year LIBOR rate on the date such payment was due to be paid or (b) the maximum applicable legal rate on such date, in either (a) or (b), calculated on the total number of days payment was delinquent.
7.10 Payment Terms. On a quarterly basis, Codexis shall submit an invoice to Merck upon receipt of each payment report and purchase order issued pursuant to Section 7.5. Upon receipt of a valid invoice from Codexis, Merck shall make net payment to Codexis within [***].
7.11 Reconciliation. In the event that Merck is determined, as a consequence of an audit conducted by Codexis pursuant to Article 8, to have either:
(a) not paid to Codexis any Agreement Payments with respect to a Merck Developed API for which Agreement Payments are payable; or
(b) underpaid any amounts by more than [***] of the undisputed amounts that should have been paid to Codexis;
(c) whether in the case of (a) or (b), for each occurrence after the first occurrence that Merck is determined, as a consequence of a separate, independent audit conducted by Codexis pursuant to Section 8.2.1 to have:
(i) not paid to Codexis any Agreement Payments with respect to a Fee Bearing Therapeutic Product for which Agreement Payments are payable; or
(ii) underpaid any amounts by more than [***] of the undisputed amounts that should have been paid to Codexis;
Merck shall pay to Codexis, within [***] from invoice by Codexis, (A) the outstanding amount due to Codexis as determined under this Section 7.11, (B) interest due in respect of the amount noted in (A) as determined pursuant to Section 7.9; and (C) the amount calculated to be [***] of the amount noted in (A) above.
8. RECORDS RETENTION AND AUDIT RIGHTS
8.1 Records Retention. Merck shall keep, and shall cause each of its Affiliates to keep, complete and accurate records (books of accounting shall be maintained in accordance with U.S. GAAP), for the following periods:
(a) for purposes of verifying Merck’s and its Affiliates’ compliance with Article 3, Section 7.4 and Section 7.7, for the immediately preceding [***]; and
(b) for purposes of verifying the accuracy of payment reports and purchase orders submitted by Merck (for its own behalf, and on behalf of its Affiliates and Third Party licensees, successors, transferees and assignees) pursuant to Section 7.5, for a period of [***] after the Calendar Year during which the payment report (and supporting documentation) and purchase order were issued.
As Merck is responsible for the payment of [***] Payments due under Section 7.4 and for submitting payment reports and purchase orders pursuant to Section 7.5 for Merck Developed API(s) manufactured by or for permitted Third Party licensees, successors, assignees and transferees, Merck shall be responsible for collecting from permitted Third Party licensees, successors, assignees and transferees and maintaining for the periods set forth in this Section 8.1 all books and records that are reasonably necessary for Merck to demonstrate compliance with Sections 7.4 and 7.5.
8.2 Audit Rights.
8.2.1 Upon the written request of Codexis and not more than [***] in each Calendar Year, Merck shall permit Codexis, through its authorized representatives (as described in Section 8.2.2) to audit Merck’s and its Affiliates’ compliance with Article 3, Section 7.4, Section 7.7 and/or to verify the accuracy of payment reports (and supporting documentation) and purchase orders submitted by Merck pursuant to Section 7.5. For the avoidance of doubt, Codexis’ exercise of its audit rights set forth above shall be limited to [***], whether it exercises its rights to audit all or any part of the areas of compliance which are subject to audit. Once an audit is complete (including any extensions of the audit to allow for investigation of issues revealed by the audit), Codexis shall [***].
8.2.2 All such audit(s) shall be conducted by an independent certified public accounting firm [***] selected by Codexis and reasonably acceptable to Merck (using, as appropriate, reputable subject matter experts for non-financial matters) and at Codexis’ expense (subject to Section 8.2.6 below). All such audits shall be conducted during normal business hours and upon reasonable advance notice and shall be limited to the books and records of Merck and its Affiliates reasonably related to the area of inquiry. Codexis shall treat all such records subject to review under this Section 8.2.2 in accordance with the confidentiality and non-use provisions of this Agreement, and shall cause its accounting firm (and associated experts) to enter into an acceptable confidentiality agreement with Merck obligating it to retain all such information in confidence pursuant to such confidentiality agreement.
8.2.3 All such audit(s) shall be limited to the applicable time periods specified in Section 8.1.
8.2.4 To the extent the audit is directed at Merck’s and/or its Affiliates’ compliance with Section 7.4, results of such investigation shall be made available to both Merck and Codexis; provided that such designee shall disclose to Codexis only its determination of whether the product constitutes a Fee Bearing Therapeutic Product and shall disclose no other information revealed in such investigation to Codexis. Any materials examined by such designee shall be deemed Merck’s Information, which may not be disclosed by such designee to any Third Party. If, as a result
of any such investigation, such designee determines that such product constitutes a Fee Bearing Therapeutic Product, then Merck shall (a) make all payments required to be made to Codexis under Section 7.4 with respect to such Fee Bearing Therapeutic Product that occurred prior to the date the Parties received such results within [***] after the date the Parties received such results, and shall be responsible for any such payments with respect to such Fee Bearing Therapeutic Product thereafter and (b) pay interest on all late payments in accordance with Section 7.9.
8.2.5 To the extent the audit is directed at Merck’s and/or its Affiliates’ compliance with Section 7.5, the report of the independent certified public accounting firm shall be shared with Merck prior to distribution to Codexis such that Merck can provide the independent, certified public accounting firm with justifying remarks for inclusion in the report prior to sharing the conclusions of such report with Codexis. Results of any such examination shall be made available to both Merck and Codexis. The independent, certified public accounting firm shall disclose to Codexis only the amounts that the independent, certified public accounting firm believes to be due and payable hereunder to Codexis and details concerning any discrepancy from the amount paid and the amount due, and shall disclose no other information revealed in such audit. Any and all records examined by such independent, certified public accounting firm shall be deemed Merck’s Information, which may not be disclosed by said independent, certified public accounting firm to any Third Party. If, as a result of any inspection of the books and records of Merck, it is shown that payments under this Agreement were less than the amount that should have been paid, then Merck shall (i) make all payments required to be made to Codexis to eliminate any discrepancy revealed by such inspection within [***] and (ii) pay interest on all late payments in accordance with Section 7.9. In the event that the audit demonstrates a net overpayment by Merck, Merck shall withhold such overpayment from future [***] Payments.
8.2.6 Codexis shall pay for such audits, except that in the event that the audited amounts reveal an underpayment, or complete failure to pay with respect to a Merck Developed API for which Agreement Payments are payable, by Merck [***] of the undisputed amounts that should have been paid during the period in question as per the audit, Merck shall pay Codexis’ out-of-pocket costs of the audit (including the fees and expenses of the independent, certified public accounting firm).
9. REPRESENTATIONS, WARRANTIES, AND COVENANTS; DISCLAIMERS; LIMITATION OF LIABILITY
9.1 Mutual Representations and Warranties. Each Party represents and warrants to the other Party as of the Effective Date [***], that:
9.1.1 such Party is duly organized, validly existing, and in good standing under the Applicable Law of the jurisdiction of its incorporation and has full corporate power and authority to enter into this Agreement and to carry out the provisions hereof;
9.1.2 execution of this Agreement and the performance by such Party of its obligations hereunder have been duly authorized;
9.1.3 this Agreement has been duly executed and delivered on behalf of such Party, and constitutes a legal, valid, binding obligation of such Party, enforceable against it in accordance with the terms hereof;
9.1.4 the performance of this Agreement by such Party does not create a breach or default under any other agreement to which it is a party, which breach or default would adversely affect the other Party;
9.1.5 the execution, delivery, and performance of this Agreement by such Party does not conflict with any agreement, instrument, or understanding, oral or written, to which it is a party or by which it is bound, nor violate any Applicable Law of any court, governmental body or administrative or other agency having jurisdiction over such Party;
9.1.6 no government authorization, consent, approval, license, exemption, filing or registration with any court or governmental department, commission, board, bureau, agency or instrumentality, domestic or foreign, under any Applicable Law currently in effect, is or will be necessary for, or in connection with, the transaction contemplated by this Agreement or any other agreement or instrument executed in connection herewith, or for the performance by such Party of its obligations under this Agreement and such other agreements, except as may be required to obtain applicable Regulatory Approvals or Regulatory Filings related to the development of any Therapeutic Product; and
9.1.7 with specific regard to each Party’s performance of their respective obligations to the other Party under this Agreement, such Party has not employed and, to its knowledge, has not used a contractor or consultant that has employed any individual or entity (a) debarred by the FDA (or subject to a similar sanction of any other applicable Regulatory Authority), (b) who is the subject of an FDA debarment investigation or proceeding (or similar proceeding of any other applicable Regulatory Authority), or (c) has been charged with or convicted under Applicable Law of the United States for conduct relating to the development or approval, or otherwise relating to the regulation of any product under the Generic Drug Enforcement Act of 1992, in each case, in the conduct of its activities prior to the Effective Date.
9.2 Additional Representations and Warranties of Codexis. Codexis, on behalf of itself and its Affiliates, hereby represents and warrants to Merck that, except as otherwise disclosed in writing by Codexis to Merck and accepted in writing by Merck, as of the Effective Date:
9.2.1 [***];
9.2.2 Codexis is the sole and exclusive owner of the Licensed Patents and the Licensed Know-How and has the full authority to grant the full and unencumbered scope of rights and licenses (other than as set forth in Exhibit 1.29) granted to Merck under this Agreement;
9.2.3 to the knowledge of Codexis Senior Management, no licenses under any Third Party Intellectual Property Rights are necessary for Codexis to grant to Merck the licenses hereunder (other than licenses to commercially available software or open source software such as, by way of example only, [***] or [***]);
9.2.4 the Licensed Patents are all of the Patents Controlled by Codexis that are (i) necessary to practice the Platform Technology; and (ii) which Cover the practice of the Platform Technology;
9.2.5 the Licensed Know-How and the In-Licensed Know-How account for all of the Know-How Controlled by Codexis that is (i) necessary to practice the Platform Technology; and (ii) which Cover the practice of the Platform Technology;
9.2.6 neither Codexis nor any of its Affiliates has granted any right, license or interest to any Third Party relating to or under the Licensed IP or to the Platform Technology that would conflict or would otherwise be inconsistent with any of the rights, licenses or interests granted to Merck under this Agreement;
9.2.7 the Licensed Know-How (other than In-Licensed Know How) were generated either by employees or contractors of Codexis, and in each case the terms of employment or engagement of such employees or contractors vested in Codexis all right, title and interest in and to any Know-How generated by them or has obtained or has the legal right to obtain assignments of all such Licensed Know-How;
9.2.8 to the knowledge of Codexis Senior Management, no Third Party has rights in the Licensed Patents, the Licensed Know-How or the Platform Technology that would adversely affect Merck’s rights under this Agreement;
9.2.9 [***];
9.2.10 [***];
9.2.11 [***];
9.2.12 in respect of each of the In-License Agreements, to the knowledge of Codexis Senior Management:
(a) each of the In-License Agreements is in full force and effect and neither Codexis nor its Affiliates have materially breached or received any written or oral notice of any breach or any written or oral notice of the intent to terminate under any of the In-License Agreements;
(b) each sublicense granted to Merck has been granted to Merck pursuant to the terms of each respective In-License Agreement;
(c) each of the In-License Agreements disclosed to Merck is true, accurate and not misleading as to the terms thereof that have not been redacted; and
(d) Exhibit 1.60 sets forth a true and complete list of all In-License Agreements;
9.2.13 [***];
9.2.14 the license limitations in Section 3.4.2 with respect to the Codexis Mayflower Patents are exhaustive, complete, accurate and not misleading; and
9.2.15 certain of the inventions claimed in the In-Licensed Patents, the Codexis Core Technology IP and the Intellectual Property Rights therein, have been made with funds provided by the U.S. government, and that with respect thereto the U.S. government retains a non-exclusive license as set forth in 35 U.S.C. § 202 and, as a result, this Agreement is subject to all of the terms and conditions of 35 U.S.C. § 200 et seq., which sets forth additional obligations with regard to inventions made with U.S. government funds and products based thereon, including a preference for manufacture in the U.S. pursuant to 35 U.S.C. § 204.
9.3 Mutual Covenants. Each Party hereby covenants to the other Party that:
9.3.1 all employees of such Party or its Affiliates, and all agents, consultants, contractors and subcontractors (as provided in Section 4.3) of such Party or its Affiliates performing any activities under a research plan under a Technology Transfer Project (including, in the case of Codexis, any Additional Services) shall be under the obligation to assign all right, title and
interest in and to their inventions and discoveries, whether or not patentable, if any, to such Party as the sole owner thereof;
9.3.2 such Party shall perform its obligations and activities under this Agreement (including, in the case of Codexis, the Additional Services) in compliance with Applicable Law and industry standards, including, without limitation, GLP, GCP and GMP, in each case as applicable under Applicable Law of the country and the state and local government wherein such activities are conducted, and with respect to the care, handling and use in research and development activities hereunder of any non-human animals by or on behalf of such Party, shall at all times comply (and shall ensure compliance by any of its subcontractors) with Applicable Law, and also with the standards in the pharmaceutical industry for the development and manufacture of pharmaceutical products, and (b) with individuals who are appropriately trained and qualified;
9.3.3 with specific regard to each Party’s performance of their respective obligations to the other Party under this Agreement, neither Party shall employ (or, to its knowledge, use any contractor or consultant that employs) any individual or entity (a) debarred by the FDA (or subject to a similar sanction of any other applicable Regulatory Authority), (b) who is the subject of an FDA debarment investigation or proceeding (or similar proceeding of any other applicable Regulatory Authority), or (c) has been charged with or convicted under any Applicable Law of the United States for conduct relating to the development, approval or otherwise relating to the regulation of any product under the Generic Drug Enforcement Act of 1992, in each case, in the conduct of its activities under this Agreement; and
9.3.4 neither Party shall, during the Term, grant any right or license to any Third Party relating to any of the Intellectual Property Rights it Controls that would conflict or interfere with any of the rights or licenses granted to the other Party hereunder.
9.4 Additional Covenants of Merck. Merck hereby covenants to Codexis that:
9.4.1 all Merck employees and contractors that will have access to Codexis Confidential Information and/or Platform Technology shall be subject to confidentiality obligations with Merck subjecting the employee or contractor to Merck’s maintenance, non-disclosure, and non-use obligations under Article 10;
9.4.2 any financial information contained in any Merck report delivered pursuant to Article 7 will be generated using the same financial reporting system, using the same data, and in the same manner that Merck uses to generate financial information for Merck’s public reporting obligations; and
9.4.3 during the Term, Merck shall not, and Merck shall cause its Affiliates and its permitted sublicensees to not, challenge the validity, scope or enforceability of or otherwise oppose any Patents included within the Licensed IP in any country[***].
9.5 Additional Covenants of Codexis. Codexis hereby covenants to Merck that:
9.5.1 with respect to each In-License Agreement, Codexis shall maintain and keep each In-License Agreement in full force and effect under each In-License Agreement’s respective terms for the term of the In-Licensed IP licensed pursuant to such In-License Agreement;
9.5.2 Codexis shall not amend any such In-License Agreement in a manner that adversely affects Merck’s rights under this Agreement and/or imposes any additional obligations upon Merck not disclosed to Merck under the In-License Agreements;
9.5.3 Codexis, pursuant to the terms of the In-License Agreements, shall pay any and all annual license fees due to all Third Party licensors during the Term required to maintain each In-License Agreement; provided, however, that nothing contained herein shall require Codexis to be responsible for Losses arising from the breach of any In-License Agreements by Merck as a sublicensee; and
9.5.4 If during the Term Merck [***] concludes that one or more [***] are necessary to [***] during the Term and in the manner contemplated by Section 9.2.1, Merck shall notify Codexis in writing [***]
[***] and Merck and Codexis shall [***]. If the Parties [***]. If the Parties [***]. If the Parties [***]. If the [***]. If the [***]. If the [***]. In no event will the [***].
9.6 DISCLAIMERS
9.6.1 CODEXIS DISCLAIMER. EXCEPT AS EXPRESSLY SET FORTH IN SECTIONS 9.1, 9.2, 9.3 AND 9.5, CODEXIS MAKES NO REPRESENTATIONS, WARRANTIES OR COVENANTS OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO ANY CODEXIS INFORMATION, CODEXIS PATENTS, CODEXIS CORE TECHNOLOGY, CODEXIS CORE TECHNOLOGY IMPROVEMENTS, MERCK CORE TECHNOLOGY IMPROVEMENTS, ARISING CODEXIS ENZYME TECHNOLOGY, ARISING CODEXIS PROCESS TECHNOLOGY OR ANY LICENSE GRANTED BY CODEXIS HEREUNDER, OR WITH RESPECT TO THE PRODUCTS. EXCEPT AS EXPRESSLY SET FORTH IN SECTIONS
9.1, 9.2, 9.3 AND 9.5, NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS A REPRESENTATION OR WARRANTY THAT ANY PATENT OR OTHER PROPRIETARY RIGHTS INCLUDED IN THE CODEXIS PATENTS ARE VALID OR ENFORCEABLE OR THAT USE OF THE CODEXIS PATENTS, CODEXIS CORE TECHNOLOGY, CODEXIS CORE TECHNOLOGY IMPROVEMENTS, MERCK CORE TECHNOLOGY IMPROVEMENTS, ARISING CODEXIS ENZYME TECHNOLOGY AND ARISING CODEXIS PROCESS TECHNOLOGY CONTEMPLATED HEREUNDER [***].
9.6.2 MERCK DISCLAIMER. EXCEPT AS EXPRESSLY SET FORTH IN SECTIONS 9.1, 9.3 AND 9.4, MERCK MAKES NO REPRESENTATIONS, WARRANTIES OR COVENANTS OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO ANY MERCK INFORMATION OR ANY LICENSE GRANTED BY MERCK HEREUNDER. EXCEPT AS EXPRESSLY SET FORTH IN SECTIONS 9.1, 9.3 AND 9.4, NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS A REPRESENTATION OR WARRANTY THAT ANY PATENT OR OTHER PROPRIETARY RIGHTS INCLUDED IN THE MERCK BACKGROUND IP, ARISING MERCK ENZYME TECHNOLOGY OR ARISING MERCK PROCESS TECHNOLOGY ARE VALID OR ENFORCEABLE OR THAT THE USE OF THE MERCK BACKGROUND IP, ARISING MERCK ENZYME TECHNOLOGY OR ARISING MERCK PROCESS TECHNOLOGY CONTEMPLATED HEREUNDER [***].
9.6.3 LIMITATION OF LIABILITY. EXCEPT FOR A BREACH OF [***], OR CLAIMS OF A THIRD PARTY THAT ARE SUBJECT TO INDEMNIFICATION UNDER ARTICLE 11, NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY WITH RESPECT TO ANY SUBJECT MATTER OF THIS AGREEMENT, WHETHER UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL OR EQUITABLE THEORY, FOR ANY INCIDENTAL, INDIRECT, SPECIAL, EXEMPLARY, PUNITIVE, MULTIPLE OR CONSEQUENTIAL DAMAGES, INCLUDING WITHOUT LIMITATION, LOST PROFITS, LOSS OF USE, DAMAGE TO GOODWILL OR LOSS OF BUSINESS.
10. CONFIDENTIALITY
10.1 Nondisclosure Obligation. All Information disclosed by one Party to the other Party hereunder shall, during the Term and for a period of ten (10) years thereafter, be (a) maintained in confidence by the receiving Party and (b) shall not be disclosed to any Third Party or (c) used for any purpose except as permitted by this Agreement (it being understood that this clause
(c) shall not create or imply any rights or licenses not expressly granted under this Agreement) without the prior written consent of the disclosing Party, except to the extent that such Information:
10.1.1 is known by the receiving Party at the time of its receipt, and not through a prior disclosure by the disclosing Party, as documented by the receiving Party’s business records;
10.1.2 is in the public domain by use and/or publication before its receipt from the disclosing Party, or thereafter enters the public domain through no fault of the receiving Party;
10.1.3 is subsequently disclosed to the receiving Party by a Third Party who may lawfully do so and is not under an obligation of confidentiality to the disclosing Party; or
10.1.4 is developed by the receiving Party independently of Information received from the disclosing Party, as documented by the receiving Party’s business records.
Any combination of features or disclosures shall not be deemed to fall within the foregoing exclusions merely because individual features are published or available to the general public or in the rightful possession of the receiving Party unless the combination itself and principle of operation are published or available to the general public or in the rightful possession of the receiving Party.
10.2 Authorized Disclosure. The receiving Party may disclose Information belonging to the disclosing Party, and Information deemed to belong to both Parties under the terms of this Agreement, to the extent and only to extent) such disclosure is reasonably necessary in the following instances the receiving Party may disclose Information belonging to the disclosing Party, and Information deemed to belong to both Parties under the terms of this Agreement, to the extent and only to extent) such disclosure is reasonably necessary in the following instances:
10.2.1 Prosecuting Patents;
10.2.2 to a Regulatory Authority in order to obtain Patents or to gain or maintain Regulatory Approval, but such disclosure may be only to the extent reasonably necessary to obtain Patents or Regulatory Approval;
10.2.3 prosecuting or defending litigation, including responding to a subpoena in a Third Party litigation;
10.2.4 subject to Section 10.5, complying with Applicable Law (including the rules and regulations of the Securities and Exchange Commission or any national securities
exchange) and with judicial process, if in the reasonable opinion of the receiving Party’s counsel, such disclosure is necessary for such compliance; and
10.2.5 disclosure, solely on a “need to know basis,” to Affiliates, sublicensees, potential or actual acquirers, merger partners, or assigns permitted under Section 14.8, permitted subcontractors, investment bankers, investors, lenders or other potential financial partners, and their and each of the Parties’ respective directors, employees, consultants, contractors and agents, each of whom prior to disclosure must be bound by written obligations of confidentiality and non-use no less restrictive than the obligations set forth in this Article 10; provided, however, that in each of the above situations, the receiving Party shall remain responsible for any failure by any Person who receives Information pursuant to this Section 10.2.5 to treat such Information as required under this Article 10.
If and whenever any Information is disclosed in accordance with this Section 10.2, such disclosure shall not cause any such Information to cease to be confidential, except to the extent that such disclosure results in a public disclosure of such Information (other than by breach of this Agreement). Where reasonably possible and subject to Section 10.4 and other than pursuant to Section 10.2.5, the receiving Party shall notify the disclosing Party of the receiving Party’s intent to make such disclosure pursuant to this Section.
If a Party is required by judicial or administrative process to disclose Information that is subject to the non-disclosure provisions of this Section 10.2, such Party shall promptly inform the other Party of the disclosure that is being sought in order to provide the other Party an opportunity to challenge or limit the disclosure obligations. Information that is disclosed by judicial or administrative process shall remain otherwise subject to the confidentiality and non-use provisions of this Section 10.2, and the Party disclosing Information pursuant to law or court order shall take all steps reasonably necessary, including without limitation obtaining an order of confidentiality, to ensure the continued confidential treatment of such Information.
10.3 Terms of this Agreement. The Parties acknowledge that this Agreement and all of the respective terms of this Agreement shall be treated as Information of both Parties, except that Exhibits [***] are Information of Codexis.
10.4 Securities. In the event either Party proposes to file with the Securities and Exchange Commission or the securities regulators of any state or other jurisdiction a registration statement or any other disclosure document which describes or refers to the terms and conditions of this Agreement under the Securities Act of 1933, as amended, the Securities Exchange Act of 1934, as amended, or any other securities Applicable Law, the Party shall notify the other Party of such
intention and shall provide such other Party with a copy of the relevant portions of the proposed filing prior to such filing (and any revisions to such portions of the proposed filing a reasonable time prior to the filing thereof), including any exhibits thereto relating to the terms and conditions of this Agreement, and shall use reasonable efforts to obtain confidential treatment of the terms and conditions of this Agreement that such other Party reasonably requests be kept confidential, and shall only disclose Information that it is advised by counsel is legally required to be disclosed. No such notice shall be required under this Section 10.4 if the description of or reference to this Agreement contained in the proposed filing has been included in any previous filing made by either Party hereunder or otherwise approved by the other Party.
10.5 Publicity/Use of Names.
10.5.1 Upon execution of this Agreement, Codexis shall issue the press release mutually agreed upon by the Parties and set forth in Exhibit 10.5.1. Any disclosure that is required by Applicable Law (including the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended), or the rules of a securities exchange or the Securities and Exchange Commission or the securities regulations of any state or other jurisdiction, may be made by Codexis or Merck; provided that any such required disclosure will not contain any Information of, respectively, Merck or Codexis and, if disclosure of such information is required by Applicable Law or such rules or regulations, the Parties will comply with Sections 10.2 and 10.5, as applicable, and will use reasonable efforts to minimize such disclosure and obtain confidential treatment for any such information that is disclosed to a governmental agency. Codexis may publicly disclose any information that has previously been disclosed in accordance with this Section 10.5.1 without any requirement to receive Merck’s approval thereof or to provide Merck with an opportunity to review such disclosure.
10.5.2 Codexis agrees to provide to Merck a copy of any public announcement regarding this Agreement or the subject matter thereof within a reasonable period of time under the circumstances prior to its scheduled release, which period of time shall not be less than fifteen (15) Business Days where practicable, for Merck’s review. Except as otherwise required by Applicable Law, Codexis shall remove any Information of Merck that Merck deems to be inappropriate for disclosure. Codexis agrees not to use the name or trademark of Merck, its Affiliates, or its employees, without the prior written consent of Merck, except that Codexis may disclose that Merck is a licensee of Codexis hereunder.
10.5.3 Merck may make public announcements and publications regarding any Merck Developed API or Therapeutic Product in its sole discretion, and such announcement or publication shall not be subject to this Section 10.5. In addition, Merck may publish scientific papers
and make scientific presentations; provided, however, that such publications and presentations do not include the Information of Codexis.
10.6 Existing CDA. The Parties entered into a confidential disclosure agreement dated as of [***] (the “Confidential Disclosure Agreement”). If any terms or conditions set forth in this Article 10 conflict with or are inconsistent with the terms and conditions of the Confidential Disclosure Agreement with respect to any information disclosed thereunder that would be considered Information hereunder, this Article 10 will govern over the Confidential Disclosure Agreement with respect to such information to the extent of such conflict or inconsistency. Subject to the foregoing, the Confidential Disclosure Agreement shall remain in full force and effect, in accordance with its terms, with respect to information disclosed thereunder to the extent such information would not be considered Information hereunder.
11. INDEMNITY AND INSURANCE
11.1 Codexis Indemnity.
11.1.1 Codexis shall indemnify, defend and hold harmless Merck and its Affiliates, and their respective officers, directors, employees, agents, licensors, and their respective successors, heirs and assigns, and representatives (the “Merck Indemnitees”), from and against any and all Losses from Claims from Third Party(ies), to the extent arising out of or relating to, directly or indirectly: (a) the negligence, recklessness or wrongful intentional acts or omissions of Codexis, its Affiliates, and sublicensees (excluding Merck) and its or their respective directors, officers, employees and agents, in connection with Codexis’ performance of its obligations or exercise of its rights under this Agreement, or (b) any breach by Codexis of any representation, warranty or covenant set forth in this Agreement; including for each of clauses (a) and (b), claims and threatened claims based on (i) product liability, bodily injury, risk of bodily injury, death or property damage or (ii) the failure to comply with Applicable Law; provided, however, that Codexis’ indemnification obligations under this Section 11.1.1 will not apply to any such Losses to the extent (A) such Losses are finally determined by a court or tribunal of competent jurisdiction to be attributable to any Merck Indemnitee having committed an act or acts of negligence, recklessness or willful misconduct, (B) such Losses result from any breach by Merck of any representation, warranty or covenant set forth in this Agreement, or (C) Merck is required to indemnify Codexis pursuant to Section 11.2.
11.1.2 Subject to the limitations set forth in Section 11.1.3, Codexis shall indemnify, defend and hold harmless Merck Indemnitees from and against any and all Losses from Claims from Third Party(ies) [***]; provided, however, that Codexis’ indemnification obligations under this Section 11.1.2 will not apply to any such Losses to the extent (A) such Losses are finally
determined by a court or tribunal of competent jurisdiction to be attributable to any Merck Indemnitee having committed an act or acts of negligence, recklessness or willful misconduct, (B) such Losses result from any breach by Merck of any representation, warranty or covenant set forth in this Agreement, or (C) Merck is required to indemnify Codexis pursuant to Section 11.2 for such Losses. [***]
11.1.3 Codexis’ indemnification obligations under Section 11.1.2 will be limited as follows: [***].
11.2 Merck Indemnity. Merck shall indemnify, defend, and hold harmless Codexis and its Affiliates, and their respective officers, directors, employees, agents, licensors, and their respective successors, heirs and assigns, and representatives (the “Codexis Indemnitees”), from and against any and all Losses from Claims from Third Party(ies) to the extent arising out of or relating to, directly or indirectly: (a) the negligence, recklessness or wrongful intentional acts or omissions of Merck, its Affiliates, and sublicensees and its or their respective directors, officers, employees and agents, in connection with Merck’s performance of its obligations or exercise of its rights under this Agreement; (b) any breach by Merck of any representation, warranty or covenant set forth in this Agreement; (c) research, development, synthesis, transfer, handling, storage, sale, use, optimization, modification, isolation, engineering, identification, selection, making, having made, importation, exportation or other disposition of any Merck Developed API or Therapeutic Product by or on behalf of Merck or any of its Affiliates, sublicensees, agents and contractors (other than Codexis) , including for each of clauses (a), (b), and (c) above, claims and threatened claims based on (i) product liability, bodily injury, risk of bodily injury, death or property damage or (ii) the failure to comply with Applicable Law; provided, however, that Merck’s indemnification obligations under this Section 11.2 will not apply to any such Losses to the extent (A) such Losses are finally determined by a court or tribunal of competent jurisdiction to be attributable to any Codexis Indemnitee having committed an act or acts of negligence, recklessness or willful misconduct, (B) such Losses result from any breach by Codexis of any representation, warranty or covenant set forth in this Agreement, or (C) Codexis is required to indemnify Merck pursuant to Section 11.1.
11.3 Indemnification Procedure. A claim to which indemnification applies under Section 11.1 or Section 11.2 shall be referred to herein as an “Indemnification Claim.” If any Person or Person (collectively, the “Indemnitee”) intends to claim indemnification under this Article 11, the Indemnitee shall notify the other Party (the “Indemnitor”) in writing promptly upon becoming aware of any claim that may be an Indemnification Claim (it being understood and agreed, however, that the failure by an Indemnitee to give such notice shall not relieve the Indemnitor of its indemnification obligation under this Agreement, except and only to the extent that the Indemnitor is
actually prejudiced as a result of such failure to give notice). The Indemnitor shall have the right to assume and control the defense of the Indemnification Claim at its own expense with counsel selected by the Indemnitor and reasonably acceptable to the Indemnitee; provided, however, that an Indemnitee shall have the right to retain its own counsel, with the fees and expenses to be paid by the Indemnitor, if representation of such Indemnitee by the counsel retained by the Indemnitor would be inappropriate due to actual or potential conflicting interests between such Indemnitee and the Indemnitor; provided that the Indemnitor shall not be obligated to pay the fees of more than one counsel retained by all Indemnitees. If the Indemnitor does not assume the defense of the Indemnification Claim as described in this Section 11.3 above, the Indemnitee may defend the Indemnification Claim, but shall have no obligation to do so. The Indemnitee shall not settle or compromise the Indemnification Claim without the prior written consent of the Indemnitor, and the Indemnitor shall not settle or compromise the Indemnification Claim in any manner which would have an adverse effect on the Indemnitee’s interests (including any rights under this Agreement), without the prior written consent of the Indemnitee, which consent, in each case, shall not be unreasonably withheld or delayed. The Indemnitee shall reasonably cooperate with the Indemnitor at the Indemnitor’s reasonable expense and shall make available to the Indemnitor all pertinent information under the control of the Indemnitee, which information shall be subject to Article 10.
11.4 Insurance. Each Party shall maintain at all times during the Term commercial general liability insurance and product liability insurance in respect of any Claim from a Third Party, as contemplated in Section 11.1.1 and Section 11.2, from a recognized, creditworthy insurance company, with coverage limits of at least [***] per such Claim from such Third Party. With respect to Merck, such product liability insurance shall include coverage for any Claims from Third Party(ies) subject to Section 11.2 in respect of any Merck Developed API or Therapeutic Product undergoing clinical trials. The minimum level of insurance set forth herein shall not be construed to create a limit on either Party’s liability hereunder. Within ten (10) days following reasonable written request from either Party, the other Party shall furnish to the requesting Party a certificate of insurance evidencing such coverage. In the case of a material modification or cancellation of such coverage, each Party shall notify the other Party as soon as reasonably practicable and provide the other Party with a new certificate of insurance evidencing that such Party’s coverage meets the requirements of this Section 11.4. Notwithstanding the aforementioned, each Party may elect to self-insure or re-insure all of parts of the limits described above and, in such event, this Section 11.4 shall apply to such self-insurance or re-insurance arrangements mutatis mutandis.
12. TERM AND TERMINATION.
12.1 Term. This Agreement shall become effective on the Effective Date and shall remain in effect unless and until terminated pursuant to Section 12.2, Section 12.3, Section 12.4 or Section 12.5, or by mutual agreement of the Parties. The period from the Effective Date until the date of termination of this Agreement shall be the “Term.”
12.2 Termination for Material Breach. Either Party (the “Non-Breaching Party”) may, without prejudice to any other remedies available to it at law or in equity, terminate this Agreement, in its entirety, in the Non-Breaching Party’s sole discretion in the event the other Party (the “Breaching Party”) has materially breached this Agreement, and such material breach has continued for sixty (60) days (the “Cure Period”) after written notice thereof is provided to the Breaching Party by the Non-Breaching Party, such notice describing the alleged material breach in sufficient detail to put the Breaching Party on notice. If at the end of the Cure Period, the Breaching Party can demonstrate that it is actively seeking to remedy such material breach, then at the Breaching Party’s request and with the consent of the Non-Breaching Party (not to be unreasonably withheld), the Non-Breaching Party shall grant an additional forty-five (45) days for the Breaching Party to remedy such breach.
12.3 Insolvency or Bankruptcy. To the extent permitted under Applicable Law, either Party may terminate this Agreement, (a) if, at any time, the other Party files in any court or agency pursuant to any statute or regulation of any state or country, a petition in bankruptcy or insolvency or for reorganization or for an arrangement or for the appointment of a receiver or trustee of the Party or of substantially all of its assets, or (b) if the other Party is served with an involuntary petition against it, filed in any insolvency proceeding, and such petition shall not be dismissed within ninety (90) days after the filing thereof, or (c) if the other Party shall propose or be a party to any dissolution or liquidation, or (d) if the other Party shall make an assignment of substantially all of its assets for the benefit of creditors. Each Party agrees to give the other Party prompt notice of the foregoing events giving rise to termination under this Section 12.3. All rights and licenses granted under or pursuant to any section of this Agreement are and shall otherwise be deemed to be for purposes of Section 365(n) of Title 11, United States Code (the “Bankruptcy Code”) licenses of rights to “intellectual property” as defined in Section 101(35A) of the Bankruptcy Code. The Parties shall retain and may fully exercise all of their respective rights and elections under the Bankruptcy Code. All materials required to be delivered by the non-bankrupt Party under this Agreement (including all manufacturing information) shall be considered to be “embodiments” of such intellectual property for purposes of Section 365(n) of the Bankruptcy Code. Upon the bankruptcy of any Party, the non-bankrupt Party shall further be entitled to a complete duplicate of, or complete access to, any intellectual property licensed to the non-bankrupt Party, and such, if not already in its possession, shall be promptly delivered to the non-bankrupt Party, unless the bankrupt Party elects to
continue, and continues, to perform all of its obligations under this Agreement. All written agreements entered into in connection with the Parties’ performance under this Agreement from time to time shall be considered agreements “supplementary” to this Agreement for purposes of Section 365(n) of the Bankruptcy Code.
12.4 Merck Termination at Will. At any time after Wave 1 (and receipt by Codexis of the Milestone Payment associated with the Completion of Wave 1 as contemplated by Section 7.3), Merck may terminate this Agreement in its entirety at any time upon providing ninety (90) days’ written notice to Codexis at any time and for any reason or for no reason at all. In such event, Merck shall pay to Codexis all reasonable non-cancellable and non-terminable costs incurred by Codexis upon such event of termination. If Merck terminates this Agreement pursuant to this Section 12.4 prior to receipt by Codexis of the Milestone Payment associated with the Completion of Wave 2 as contemplated by Section 7.3, in addition to the provisions of Section 12.6.2, Merck shall pay to Codexis the applicable termination payment set forth in this Section 12.4.
| | | | | |
| Termination at Will | Termination At Will Payment |
| At any time after Wave 1, as defined in the Technology Transfer Plan | $8,000,000.00 |
12.5 Codexis Special Termination Right. In the event that Merck is determined, [***], as a consequence of an audit conducted by Codexis pursuant to Article 8 (each audit that satisfies the requirements of either clause (a) or (b) of this Section 12.5 is referred to herein as a “Section 12.5 Event”), to have either underpaid or completely failed to pay the amounts that should have been paid to Codexis such that Merck is required to pay Codexis’ out-of-pocket costs of the audit pursuant to Section 8.2.6, Codexis may[***] terminate this Agreement in its entirety, without a curative period, and regardless of whether Merck can or does cure such failure to pay or underpayment, upon providing thirty (30) days’ written notice to Merck. [***]
12.6 Consequences of Termination.
12.6.1 In General. Termination of this Agreement for any reason shall not (a) release either Party from any obligation that has accrued prior to the effective date of such termination; (b) preclude either Party from claiming any other damages, compensation, or relief that it may be entitled to upon such termination; (c) terminate any right to obtain performance of any obligation provided for in this Agreement that shall survive termination; or (d) in any way alter, reduce, diminish, eliminate or expunge either Party’s rights set forth in Section 6.2.9, or such Party’s right to freely use any Enzymes it owns, post termination. Upon any termination of this Agreement,
each Party shall return to the other Party and cease using all Information of such other Party; provided that the legal department of each Party may retain one (1) copy of such Information and the Party having received the Information of the disclosing Party shall not be required to destroy any securely stored computer files that contain the disclosing Party’s Information created during automatic system back-ups, provided that the Information so retained remains subject to the confidentiality and non-use obligations set forth in this Agreement and the computer files are not readily accessible to the receiving Party’s employees.
12.6.2 Effects of Termination.
(a) Upon any permitted termination of this Agreement by Codexis pursuant to Section 12.2, 12.3 or 12.5, or termination by Merck pursuant to Section 12.4, (i) the rights and licenses granted to Merck in Sections [***] shall immediately terminate, and Merck shall, within [***] after the effective date of such termination, return or cause to be returned to Codexis the Platform Technology to the extent in tangible form, (ii) [***], and (iii) the rights and licenses granted to Codexis in Sections [***] shall survive. In the event of termination by Codexis pursuant to Section 12.2 for breach by Merck or its Affiliates of its obligations under Section 9.4.3, the licenses granted to Merck pursuant to Section [***] and Section [***] shall immediately terminate, and Merck shall, within [***] after the effective date of such termination, return or cause to be returned to Codexis the Platform Technology to the extent in tangible form.
(b) Upon any permitted termination of this Agreement by Merck pursuant to Section 12.2, [***] all rights and licenses granted to Codexis hereunder shall immediately terminate, and Codexis shall, within [***] after the effective date of such termination return or cause to be returned to Merck all Technology and Information of Merck in tangible form, and all substances or compositions delivered or provided by Merck, as well as any other material provided by Merck in any medium.
(c) Upon any permitted termination of this Agreement by Merck pursuant to Section 12.3 (i) the licenses granted to Merck pursuant to Sections [***] shall survive and all payment and reporting obligations hereunder (including, without limitation, those set forth in Article 7) and records retention and audit rights set forth in Article 8 shall survive; and (ii) all rights and licenses granted to Codexis hereunder shall survive.
12.6.3 Codexis Audit Right on Merck Breach; Termination; Divestment. In the event of termination of this Agreement by Codexis pursuant to Section 12.2, 12.3 or 12.5, or by Merck pursuant to Section 12.4, or if Merck sells, leases, loans, provides or otherwise divests to any Third Party any facility or business unit that practices or otherwise uses any Codexis Core Technology, Codexis Core Technology Improvements or other Technology related to Covered
Enzymes or Enzymes, Merck shall provide to Codexis, within ninety (90) days after the effective date of such termination, or within ninety (90) days after the effective date of such divestment, as applicable, a certification signed by a duly authorized executive or non-executive officer of Merck, certifying that all Codexis proprietary materials, information, and technology in custody or control of Merck or sublicensee of Merck, or at the divested facility or business unit, has been destroyed (including, without limitation, all Codexis Software). In addition, Codexis shall have a right to conduct an audit to determine that all Codexis materials, information, and/or technology have been destroyed and that such destruction is complete (the “Termination and Divestment Audit Right”). Under the Termination and Divestment Audit Right, Merck shall allow a designee chosen by Codexis and reasonably acceptable to Merck to review documentation, materials, and facilities of Merck as reasonably necessary for such designee to determine whether all Codexis materials, information, and/or technology have been destroyed. Results of such investigation shall be made available to both Merck and Codexis; provided that such designee shall disclose to Codexis only its determination of whether all Codexis materials, information, and/or technology has been destroyed. Merck may require such designee to enter into an appropriate written agreement obligating it to be bound by obligations of confidentiality and restrictions on use of such Information that are comparable to the obligations set forth in Article 10. The Termination and Divestment Audit Right shall continue until the earlier of (a) ten (10) years after the effective date of termination of this Agreement by Codexis pursuant to Section 12.2, 12.3 or 12.5, or by Merck pursuant to Section 12.4 or (b) until a designee determines, pursuant to the Codexis’ exercise of the Termination and Divestment Audit Right, that all Codexis materials, information, and/or technology has been destroyed. All reasonable expenses arising from the first audit shall be at Codexis’ expense, and all subsequent audits, if any, shall be at Merck’s expense.
12.7 Survival. Notwithstanding anything to the contrary in this Agreement:
12.7.1 the following provisions shall survive, as well as any other provision which by its terms or by the context thereof is intended to survive, termination of this Agreement: Article 1 (Definitions), Article 6 (Intellectual Property), Article 10 (Confidentiality) (for the time period set forth in Section 10.1), Article 14 (Miscellaneous), and Sections 3.3, 3.4.1, 3.4.2, 3.4.3, 3.4.5, 3.6.2, 9.6, 11.1, 11.2, 11.3, 12.6 and 12.7;
12.7.2 Article 8 (Records Retention and Audit Rights) and Sections 3.1, 3.2, 3.5.6, 7.4, 7.5, 7.6, 7.8, 7.9, 7.10 and 7.11 shall survive termination in accordance with Section 12.6.2;
12.7.3 Section 3.6 shall survive termination solely to the extent that Sections 3.2 and/or 3.5.6 survive termination in accordance with Section 12.6.2; and
12.7.4 Section 7.7 shall survive termination if the Agreement is terminated by Codexis pursuant to Sections 12.2, 12.3 or 12.5 or by Merck pursuant to Section 12.4.
Except as otherwise expressly provided, all other rights, licenses and obligations shall terminate upon termination of this Agreement.
13. DISPUTE RESOLUTION.
13.1 Resolution by Executive Officers. The Parties agree that the procedures set forth in this Article 13 shall be the exclusive mechanism for resolving any dispute, controversy, or claim, which are not Excluded Claims, (each, a “Dispute”) between the Parties that may arise from time to time pursuant to this Agreement relating to any Party’s rights and/or obligations. Except as otherwise provided in this Agreement, in the event of any Dispute between the Parties in connection with this Agreement, the construction hereof, or the rights, duties or liabilities of either Party hereunder, the Parties shall first attempt in good faith to resolve such Dispute by negotiation and consultation between themselves. In the event that such Dispute is not resolved on an informal basis within ten (10) Business Days, either Party may, by written notice to the other Party, refer the Dispute to the executive officers designated by the Parties for attempted resolution. Such officers, or their designees, shall attempt in good faith to promptly resolve such Dispute within thirty (30) Business Days thereafter. In the event that any matter is not resolved under the foregoing provisions, each Party may, at its sole discretion, seek resolution of such matter in accordance with Section 13.2.
13.2 Arbitration. Subject to Section 13.3, any Dispute referred for arbitration shall be finally resolved by binding arbitration before a panel of three (3) arbitrators in accordance with the rules of the American Arbitration Association (“AAA”) in effect at the time the proceeding is initiated. If the issues in Dispute involve scientific, technical or commercial matters, then any arbitrator chosen under this Agreement shall have educational training and industry experience sufficient to demonstrate a reasonable level of relevant scientific, technical and commercial knowledge relevant to the subject matter of the Dispute. All proceedings and communications as part of the arbitration shall be in English. Following selection of the third arbitrator, the arbitrators shall use all reasonable efforts to complete the arbitration proceedings and render an award within six (6) months after the last arbitrator is appointed. In any such arbitration, the following additional procedures shall apply:
13.2.1 Rules. The arbitration shall be conducted pursuant to the then-current AAA rules in effect for disputes between U.S. parties on the date of commencement of the arbitration; provided, however, that discovery in any arbitration shall be conducted in accordance with
the AAA Commercial Arbitration Rules in effect immediately prior to October 1, 2013, for large complex commercial disputes between U.S. based entities.
13.2.2 Panel. Within thirty (30) days after a Party demands arbitration, each Party shall select one (1) arbitrator and the third chosen by the two (2) Party-chosen arbitrators. If either, or both, of Merck or Codexis fails to choose an arbitrator within thirty (30) days after receiving notice of commencement of arbitration or if the two arbitrators fail to choose a third arbitrator within thirty (30) days after their appointment , then either or both Parties shall immediately request that the AAA select the remaining number of arbitrators to be selected, which arbitrator(s) shall have an appropriate background, experience and expertise in the subject matter at issue in the Dispute. The place of arbitration shall be [***], United States of America. The seat of arbitration shall be the State of New York, United States of America (for clarity, the Parties intend this to mean that the procedural rules of the State of New York, United States of America, will apply to any arbitration).
13.2.3 Injunctive Relief; Costs and Expenses. Either Party may apply to the arbitrators for interim injunctive relief until the arbitration decision is rendered or the Dispute is otherwise resolved. Either Party may, without waiving any right or remedy under this Agreement, seek from any court having jurisdiction any injunctive or provisional relief necessary to protect the rights or property of that Party pending resolution of the Dispute pursuant to this Article 13. The arbitrators shall have no authority to award punitive or any other type of damages not measured by a Party’s compensatory damages. Each Party will share equally the cost and expenses of the panel selected in Section 13.2.2 and any administrative fees unless in each case the arbitrators agree otherwise, which they are hereby empowered, authorized and instructed to do if they determine that to be fair and appropriate. Each Party shall bear its own costs and expenses and attorneys’ fees in connection with any such arbitration; provided, however, that the prevailing Party in any such arbitration shall be entitled to recover from the other Party the reasonable attorneys’ fees, costs and expenses incurred by such prevailing Party in connection with such arbitration.
13.2.4 Confidentiality. Except to the extent necessary to confirm an award or decision or as may be required by Applicable Law, or the requirement of any exchange on which a Party’s shares are traded, neither Party nor any arbitrator may disclose the existence or results of any arbitration without the prior written consent of both Parties. In no event shall any arbitration be initiated after the date when commencement of a legal or equitable proceeding based on the Dispute would be barred by the applicable New York statute of limitations.
13.2.5 Breach of the Agreement. In the event of a Dispute involving the alleged breach of this Agreement (including, without limitation, whether a Party has satisfied its diligence obligations hereunder), (a) neither Party may terminate this Agreement under Section 12.2
until resolution of the Dispute pursuant to this Article 13 and (b) if the arbitrators render a decision that a breach of this Agreement has occurred, the arbitrators shall have no authority to modify the right of the non-breaching Party to terminate this Agreement in accordance with Section 12.2.
13.2.6 Performance. Any disputed performance or suspended performance pending the resolution of a Dispute that the arbitrators determine to be required to be performed by a Party shall be completed within a reasonable time period following the final decision of the arbitrators.
13.2.7 Binding Decision. The decision of the arbitrators shall be the sole, exclusive and binding remedy between the Parties regarding the determination of all Disputes presented. The arbitrators shall prepare and deliver to the Parties a written, reasoned opinion conferring their decision. Judgment on the award so rendered may be entered in any court having competent jurisdiction thereof. Any monetary payment to be made by a Party pursuant to a decision of the arbitrators shall be made in Dollars, free of any tax or other deduction.
13.3 [***]. Notwithstanding anything in this Agreement to the contrary, any and all issues regarding (a) [***], (b) [***], or (c) any other [***], shall be [***]. This Section 13.3 shall not be construed to [***].
14. MISCELLANEOUS.
14.1 Regulatory Responsibilities and Costs. As between the Parties, Merck shall prepare, file, maintain and own all Regulatory Filings and related submissions with respect to all Therapeutic Products and shall bear the cost of such preparation, filing, maintenance and ownership. As between the Parties, Merck shall be solely responsible for communicating with the FDA and/or any other Regulatory Authority in any country or jurisdiction regarding all Therapeutic Products.
14.2 Commercialization Responsibilities and Costs. As between the Parties, Merck shall be solely responsible for all commercialization activities relating to Therapeutic Products, at Merck’s sole cost and expense, and shall have sole decision-making authority with respect to the foregoing. Merck shall conduct all commercialization activities under this Agreement in compliance with all Applicable Law. For clarity, nothing in this Agreement shall require Merck to develop or commercialize any minimum number of Therapeutic Products or limit the number of Therapeutic Products that Merck may develop or commercialize.
14.3 Party Employees. Notwithstanding anything to the contrary under this Agreement, under no circumstance would any employee, contractor, contingent worker or consultant of a Party be considered an employee, contractor, contingent worker or consultant of the other Party.
The Party who sends any employee, contractor, contingent worker or consultant to work at the other Party’s premises shall assume all liability for such employees, contractors, contingent workers or consultants working at the other Party’s premises and shall procure that its employees, contractors, contingent workers or consultants comply with all security, health and safety and other policies applicable to occupiers of the hosting Party’s premises.
14.4 Non-Solicitation. During the period beginning on the Effective Date and ending on the date that is [***] (the “Non-Solicitation Period”), neither Party shall directly or indirectly, solicit, hire, employ or attempt to solicit, hire or employ any person acting in a scientific role who is or was an employee or contractor of the other Party or such other Party’s Affiliates during the Non-Solicitation Period, or in any other way directly or indirectly seek to solicit, induce, bring about, influence, promote, facilitate, or encourage any such individual to work for such Party; provided that the foregoing shall not restrict a Party or its Affiliates from advertising employment opportunities in any manner that does not directly target the other Party or its Affiliates or from hiring or employing any person who responds to such generalized public advertisements.
14.5 Severability. If any one or more of the provisions contained in this Agreement is held invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein shall not in any way be affected or impaired thereby, unless the absence of the invalidated provision(s) adversely affects the substantive rights of the Parties. The Parties shall in such an instance use reasonable efforts to replace the invalid, illegal or unenforceable provision(s) with valid, legal and enforceable provision (s) which, insofar as practical, implement the purposes of this Agreement.
14.6 Notices. All notices which are required or permitted hereunder shall be in writing and sufficient if delivered personally, sent by facsimile (and promptly confirmed by personal delivery, registered or certified mail or overnight courier), sent by nationally-recognized overnight courier or sent by registered or certified mail, postage prepaid, return receipt requested, addressed as follows:
| | | | | |
| if to Codexis, to: | Codexis, Inc. |
| 200 Penobscot Drive |
| Redwood City, CA 94063 |
| Attention: [***] |
| Fax: [***] |
| Email: [***] |
| |
| and: | Codexis, Inc. |
| 200 Penobscot Drive |
| Redwood City, CA 94063 |
| Attention: [***] |
| Telephone: [***] |
| Fax: [***] |
| Email: [***] |
| | | | | |
| if to Merck, to: | Merck Sharp & Dohme Corp. |
| One Merck Drive |
| P.O. Box 100, WS3A-65 |
| Whitehouse Station, NJ 08889-0100 |
| Attention: [***] |
| Facsimile No.: [***] |
| |
| and | Merck Sharp & Dohme Corp. |
| 2000 Galloping Hill Road |
| Kenilworth, NJ 07033 |
| Attention: [***] |
| Facsimile: [***] |
or to such other address(es) as the Party to whom notice is to be given may have furnished to the other Party in writing in accordance herewith. Any such notice shall be deemed to have been given: (a) when delivered if personally delivered or sent by facsimile on a business day (or if delivered or sent on a non-business day, then on the next business day); (b) on the business day after dispatch if sent by nationally-recognized overnight courier; or (c) on the fifth (5th) business day following the date of mailing, if sent by mail.
14.7 Force Majeure. Except for the payment of money, neither Party shall be held liable to the other Party nor be deemed to have defaulted under or breached this Agreement for failure or delay in performing any obligation under this Agreement to the extent such failure or delay is caused by or results from causes beyond the reasonable control of the affected Party, potentially
including, but not limited to, embargoes, war, acts of war (whether war be declared or not), acts of terrorism, insurrections, riots, civil commotions, strikes, lockouts or other labor disturbances, fire, floods, or other acts of God, or acts, omissions or delays in acting by any governmental authority or the other Party. The affected Party shall notify the other Party of such force majeure circumstances as soon as reasonably practical, and shall promptly undertake Commercially Reasonable Efforts to cure such force majeure circumstances.
14.8 Assignment. Except as provided in this Section 14.8, this Agreement may not be assigned or otherwise transferred, nor may any right or obligation hereunder be assigned or transferred, by either Party without the consent of the other Party; provided, however, that either Party may, without such consent, assign this Agreement and its rights and obligations hereunder, in whole or in part, to an Affiliate or in connection with the transfer or sale of all or substantially all of its assets related to the subject matter of this Agreement, or in the event of its merger or consolidation or change in control or similar transaction. This Agreement shall inure to the benefit of and be binding on the Parties’ successors and assigns. Any attempted assignment not in accordance with this Section 14.8 shall be void. Any permitted assignee shall assume all assigned obligations of its assignor under this Agreement.
14.9 Waivers and Modifications. The waiver by either Party hereto of any right hereunder, or of any failure of the other Party to perform, or of any breach by the other Party, shall not be deemed a waiver of any other right hereunder or of any other breach by or failure of such other Party whether of a similar nature or otherwise. No waiver, modification, release or amendment of any obligation under or provision of this Agreement shall be valid or effective unless in writing and signed by both Parties.
14.10 Applicable Law. This Agreement shall be governed by and construed in accordance with the laws of the State of New York and the patent laws of the United States without reference to any rules of conflict of laws or renvoi, and excludes (a) the United Nations Convention on Contracts for the International Sales of Goods; (b) the 1974 Convention on the Limitation Period in the International Sale of Goods (the “1974 Convention”); (c) the Protocol amending the 1974 Convention, done at Vienna April 11, 1980; and (d) the Uniform Computer Information Transactions Act; provided, however, that with respect to matters involving the enforcement, validity or scope of Intellectual Property Rights, the laws of the applicable country shall apply.
14.11 Independent Contractors. It is expressly agreed that Codexis and Merck shall be independent contractors and that the relationship between the two Parties shall not constitute a partnership, joint venture or agency. Neither Codexis nor Merck shall have the authority to make
any statements, representations or commitments of any kind, or to take any action, which shall be binding on the other Party, without the prior written consent of the other Party.
14.12 Entire Agreement. This Agreement, together with the Exhibits hereto, contains the entire understanding of the Parties with respect to the subject matter hereof. Any other express or implied agreements and understandings, negotiations, writings and commitments, either oral or written, in respect to the subject matter hereof are superseded by the terms of this Agreement. The Exhibits to this Agreement are incorporated herein by reference and shall be deemed a part of this Agreement. This Agreement may be amended, or any term hereof modified, only by a written instrument duly executed by authorized representative(s) of both Parties hereto. Notwithstanding anything to the contrary in the foregoing, and subject to Section 10.6 hereof, the Confidential Disclosure Agreement shall remain in full force and effect with respect to the subject matter thereof and information disclosed thereunder.
14.13 Counterparts. This Agreement may be signed in any number of counterparts (facsimile and electronic transmission included), each of which shall be deemed an original, but all of which shall constitute one and the same instrument. After facsimile or electronic transmission, the parties agree to execute and exchange documents with original signatures.
14.14 Waiver of Rule of Construction. Each Party has had the opportunity to consult with counsel in connection with the review, drafting and negotiation of this Agreement. Accordingly, the rule of construction that any ambiguity in this Agreement shall be construed against the drafting Party shall not apply.
14.15 Certain Conventions. Any reference in this Agreement to an Article, Section, subsection, paragraph, clause, Exhibit shall be deemed to be a reference to an Article, Section, subsection, paragraph, clause, or Exhibit, of or to, as the case may be, this Agreement, unless otherwise indicated. Unless the context of this Agreement otherwise requires, (a) words of any gender include each other gender, (b) words such as “herein”, “hereof”, and “hereunder” refer to this Agreement as a whole and not merely to the particular provision in which such words appear, (c) words using the singular shall include the plural, and vice versa.
14.16 Headings. The captions to the several Articles, Sections and subsections hereof are not a part of this Agreement, but are merely for convenience to assist in locating and reading the several Articles and Sections hereof.
14.17 Cumulative Remedies. No remedy referred to in this Agreement is intended to be exclusive, but each shall be cumulative and in addition to any other remedy referred to in this Agreement or otherwise available under law.
14.18 References. Unless the context requires otherwise, (a) any definition of or reference to any agreement, instrument or other document herein shall be construed as referring to such agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein or therein), (b) any reference to Applicable Law herein shall be construed as referring to such Applicable Law as from time to time enacted, repealed or amended, and (c) any reference herein to any Person shall be construed to include the Person’s successors and assigns.
14.19 Ethical Business Practices.
14.19.1 Codexis acknowledges that Merck’s corporate policy requires that Merck’s business must be conducted within the letter and spirit of the law. By signing this Agreement, Codexis agrees to conduct the services contemplated herein in a manner which is consistent with both law and good business ethics.
14.19.2 Codexis warrants that [***]. Codexis shall not make any payment, either directly or indirectly, of money or other assets, including but not limited to the compensation Codexis derives from this Agreement (hereinafter collectively referred as a “Payment”), to government or political party officials, officials of international public organizations, candidates for public office, or representatives of other businesses or persons acting on behalf of any of the foregoing (hereinafter collectively referred as “Officials”) where such Payment would constitute violation of any law. In addition regardless of legality, Codexis shall make no Payment either directly or indirectly to Officials if such Payment is for the purpose of influencing decisions or actions with respect to the subject matter of this Agreement.
14.19.3 Codexis acknowledges that no employee of Merck or its Affiliates shall have authority to give any direction, either written or oral, relating to the making of any commitment by Codexis or its agents to any Third Party in violation of terms of this or any other provisions of this Agreement.
14.19.4 Codexis certifies to Merck that as of the date of this Agreement [***]. After the execution of this Agreement, Codexis shall [***].
14.19.5 [***]
[Signature Page Follows]
IN WITNESS WHEREOF, the Parties have caused this Platform Technology Transfer and License Agreement to be executed by their respective duly authorized officers as of the Effective Date.
| | | | | |
| Codexis, Inc. | Merck Sharp & Dohme Corp. |
| By: /s/ John Nicols | By: /s/ Iain Dukes |
| Name: John Nicols | Name: Iain Dukes, D. Phil |
| Title: President and CEO | Title: Senior Vice President |
Exhibit 1.19
Codexis Core Patents
Attached.
EXHIBIT 1.19
| | | | | | | | | | | | | | | | | | | | | | | |
| CODEXIS CORE PATENTS |
| Country | Application Title | Application Status | Application Number | Filing Date | Publication Number | Patent Number | Issue Date |
| US | COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS | Granted | 12/562,988 | 09/18/2009 | US-2010-0093560A1 | 8383346 | 02/26/2013 |
| CN | METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS | Granted | 200980122093.2 | 12/13/2010 | 102066561 | 200980122093.2 | 09/25/2013 |
| CA | METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS | Granted | 2,726,850 | 12/02/2010 | 2726850 | 2726850 | 06/02/2015 |
| EP | METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS | Allowed | 9763625.2 | 11/29/2010 | 2285958 | | |
| IN | METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS | Published | 8090/CHEN/2010 | 12/13/2010 | 8090/CHENP/2010A | | |
| SG | METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS | Granted | 201009215-3 | 12/13/2010 | | 167342 | 05/31/2013 |
| CA | COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS | Allowed | 2763017 | 11/21/2011 | 2763017 | | |
| CN | COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS | Granted | 200980159766.1 | 12/08/2011 | 102803489 | ZL200980159766.1 | 01/28/2015 |
| EP | COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS | Published | 9845944.9 | 12/05/2011 | 2451951 | | |
| IN | COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS | Published | 9101/CHENP/2011 | 12/07/2011 | 9101/CHENP/2011 A | | |
| US | COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS | Published | 14/505209 | 10/02/2014 | 20150024971 | | |
CODEXIS CONFIDENTIAL INFORMATION
-1-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | METHOD OF SELECTING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS | Granted | 12/867429 | 08/12/2010 | US20110029468 | 8504498 | 08/06/2013 |
| EP | METHOD OF SELECTING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS | Published | 9710859.1 | 02/12/2009 | 2250595 | | |
| EP | METHOD OF GENERATING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS | Published | 9710490.5 | 02/12/2009 | 2250594 | | |
| US | METHOD OF GENERATING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS | Granted | 12/867433 | 10/21/2010 | 2011-0034342 | 8768871 | 07/01/2014 |
| US | METHOD OF GENERATING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS | Published | 14/281421 | 05/19/2014 | 2014/0256557 | | |
| EP | REDUCED CODON MUTAGENESIS | Published | 10817881.5 | 03/30/2012 | 2478137 | | |
| US | PROTEIN VARIANT GENERATION BY REGION SHUFFLING | Published | 13/577,651 | 08/07/2012 | 2014/0005057 | | |
| EP | PROTEIN VARIANT GENERATION BY REGION SHUFFLING | Published | 12803889.0 | 12/12/2013 | 2726651 | | |
| US | GENE SHUFFLING METHODS | Published | 14/385060 | 09/12/2014 | 20150050658 | | |
| EP | GENE SHUFFLING METHODS | Published | 13760490.6 | 10/14/2014 | 2825647 | | |
| US | METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING BIO-MOLECULES WITH INTERACTING COMPONENTS | Published | 14/167709 | 01/29/2014 | 20140214391 | | |
| WO | METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING BIO-MOLECULES WITH INTERACTING COMPONENTS | Published | PCT/US2014/013666 | 01/29/2014 | WO2014120819 | | |
| US | STRUCTURE BASED PREDICTIVE MODELING | Published | 14/498881 | 09/26/2014 | 20150134315 | | |
CODEXIS CONFIDENTIAL INFORMATION
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| | | | | | | | | | | | | | | | | | | | | | | |
| WO | STRUCTURE BASED PREDICTIVE MODELING | Published | PCT/US2014/057900 | 09/26/2014 | WO2015048573 | | |
| US | AUTOMATED SCREENING OF ENZYME VARIANTS | Published | 14/498864 | 09/26/2014 | 20150133307 | | |
| WO | AUTOMATED SCREENING OF ENZYME VARIANTS | Published | PCT/US2014/057899 | 09/26/2014 | WO2015048572 | | |
| US | METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING BIO-MOLECULES USING MODELS OF MULTIPLICATIVE FORM | Published | 14/167713 | 01/29/2014 | 20140221216 | | |
| WO | METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING BIO-MOLECULES USING MODELS OF MULTIPLICATIVE FORM | Published | PCT/US2014/013668 | 01/29/2014 | WO2014120821 | | |
CODEXIS CONFIDENTIAL INFORMATION
-3-
Exhibit 1.20
Codexis Core Technology
The enzyme optimization process starts by identifying genes that code for enzymes known to have the general type of catalytic reactivity for a desired chemical reaction. Typically, we identify gene sequences in published databases and then synthesize candidate genes having those sequences. Using a variety of biotechnology tools, we diversify these genes by introducing mutations, giving rise to changes in the enzymes for which they encode. The methods for diversifying these genes, and types of diversity being tested, often vary over the course of an enzyme optimization program. For finding initial diversity, methods typically include random mutagenesis and site-directed (included structure-guided) mutagenesis. We also test mutational variations that distinguish related enzymes among different organisms. Once we have identified potentially beneficial mutations, we test combinations of these mutations in libraries made using our proprietary gene recombination methodologies, gene shuffling and multiplexed gene SOEing, or Splicing by Overlap Extension.
With our proprietary gene shuffling methodology, we generate libraries of genes that have random combinations of the mutations we are testing. The pool of genes is used to transform host cells, which entails introducing the various genes, one by one, into host cells. These cells are then segregated and grown into colonies. Cells from individual colonies are cultured in high throughput to produce the enzyme encoded by the shuffled gene in those cells. The enzymes are then screened in high throughput using test conditions relevant to the desired process. The screening results identify individual shuffled genes that produce improved enzymes having combinations of beneficial mutations and weed out enzymes having detrimental ones. Using different test conditions and/or different analytical methods, we can identify variant enzymes that exhibit various improved performance characteristics, such as stability, activity and selectivity, under conditions relevant to the desired chemical process.
In the next step in our optimization process, we use our proprietary software tool, ProSAR™, to analyze protein sequence-activity relationships. ProSAR™ aids in identifying specific gene and enzyme mutations that are beneficial, neutral or detrimental with respect to the desired performance characteristics. Earlier directed evolution methods did not separately evaluate individual mutations in libraries of variants which carry multiple mutations, where beneficial and detrimental performance characteristics may be mixed in an individual gene or enzyme. Capitalizing on the advent of inexpensive gene sequencing, we are able to determine which particular mutations are present in the genes and proteins we have screened. Our ProSAR™ bioinformatics software relates the screening results to the mutations and ranks the individual mutations with regard to their degree of benefit or detriment, relative to whichever process parameter(s) the screening tested. Using that information, we can bias the pool of mutational diversity in the next iteration to further the accumulation of beneficial diversity and cancel out detrimental diversity in the individual genes in the resulting shuffled library. The ProSAR™ results also help us develop ideas about new diversity to test. ProSAR™, combined with efficient gene synthesis and high quality library generation methods, has led to a significant increase in the efficiency and speed of enzyme improvement and optimization.
In another step of our optimization process, we take the best variants we have identified and prepare enough of each to test in the desired chemical process at laboratory scale, for in-process confirmation. This optimization routine is done iteratively, typically adding new diversity to the pool in each iteration. The gene that codes for the best performing enzyme in one iteration is used as the starting gene for the next iteration of shuffling and screening. As the enzymes improve over these iterations, the screening conditions are made increasingly more stringent. In this way, enzymes are rapidly optimized until all in-process performance requirements have been achieved and the economic objectives for the desired process have been met.
Multiplexed gene SOEing is our proprietary methodology for rapidly generating gene variants. Using multiplexed gene SOEing, we rapidly generate collections of individual gene variants that have predetermined, as opposed to random, combinations of mutations we are testing. It is based on a biotechnology technique, which we refer to as SOEing, generally used to make a hybrid, or spliced, gene from fragments of two genes and/or to introduce a specific mutation into a splice between fragments of one gene. We have automated the process to make robotically, in parallel, one hundred to several hundred variants, each with a predetermined combination of the mutations we are testing. The variants are introduced into host cells, and the encoded enzyme is produced and screened in high throughput, as described above.
Using multiplexed gene SOEing, we can test many mutations and combinations thereof in parallel, and because the mutation incorporation is controlled and predetermined before screening, as opposed to random incorporation and selection after screening, the resulting data set can be more optimal for ProSAR™ analysis.
We believe using multiplexed gene SOEing to survey many mutations quickly, followed by ProSAR™-driven shuffling of beneficial mutations, is a particularly effective approach, providing rapid gains in enzyme performance.
Exhibit 1.25
Codexis Enzyme Patents
Attached.
EXHIBIT 1.25
| | | | | | | | | | | | | | | | | | | | | | | |
| CODEXIS ENZYME PATENTS |
| Country | Application Title | Application Status | Application Number | Filing Date | Publication Number | Patent Number | Issue Date |
| US | TRANSAMINASE POLYPEPTIDES | Granted | 12/684,864 | 01/08/2010 | 20100209981A1 | 8470564 | 06/25/2013 |
| EP | TRANSAMINASE POLYPEPTIDES | Published | 10729606.3 | 01/08/2010 | 2385983 | | |
| SG | TRANSAMINASE POLYPEPTIDES | Granted | 201104947-5 | 07/06/2011 | 172891 | 172891 | 11/26/2014 |
| IN | TRANSAMINASE POLYPEPTIDES | Published | 5648/CHENP/2011 | 08/04/2011 | 5648/CHENP/2011 | | |
| IL | TRANSAMINASE POLYPEPTIDES | Pending | 213950 | 07/06/2011 | | | |
| CN | TRANSAMINASE POLYPEPTIDES | Granted | 201080010926.9 | 01/08/2010 | 102341494 | ZL201080010926.9 | 10/15/2014 |
| US | TRANSAMINASE POLYPEPTIDES | Granted | 13/920,902 | 06/18/2013 | 2013/0266994A1 | 9029106 | 05/12/2015 |
| US | TRANSAMINASE POLYPEPTIDES | Pending | 14/684916 | 04/13/2015 | | | |
| US | TRANSAMINASE BIOCATALYSTS | Granted | 12/714,397 | 02/26/2010 | 20100285541A1 | 8293507 | 10/23/2012 |
| CN | TRANSAMINASE BIOCATALYSTS | Granted | 201080017312.3 | 10/19/2011 | 102405281 | 102405281 | 05/13/2015 |
| EP | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| IN | TRANSAMINASE BIOCATALYSTS | Published | 6857/CHENP/2011 | 09/22/2011 | 6857/CHENP/2011 | | |
| SG | TRANSAMINASE BIOCATALYSTS | Granted | 201106064-7 | 02/26/2010 | 173815 | 173815 | 11/15/2013 |
| JP | TRANSAMINASE BIOCATALYSTS | Granted | 2011-552209 | 08/23/2011 | 2012-519004 | 5707344 | 03/06/2015 |
| US | TRANSAMINASE BIOCATALYSTS | Granted | 13/604,323 | 09/05/2012 | 20120329108A1 | 8889380 | 11/18/2014 |
| DE | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 202010012539.4 | 12/18/2013 |
| FR | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| ES | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| CH | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| GB | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| IE | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| IT | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-1-
| | | | | | | | | | | | | | | | | | | | | | | |
| NL | TRANSAMINASE BIOCATALYSTS | Granted | 10746948.8 | 09/26/2011 | 2401366 | 2401366 | 12/18/2013 |
| JP | TRANSAMINASE BIOCATALYSTS | Pending | 2014-186102 | 09/12/2014 | | | |
| US | TRANSAMINASE BIOCATALYSTS | Allowed | 14/518143 | 10/20/2014 | 20150037869 | | |
| CN | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Granted | 201080027481.5 | 12/20/2011 | 102482648 | ZL201080027481.5 | 12/10/2014 |
| EP | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Published | 10797576.5 | 12/22/2011 | 2446025 | | |
| IN | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Pending | 9363/CHENP/2011 | 12/21/2011 | | | |
| SG | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Granted | 201109538-7 | 12/21/2011 | 177331 | 177331 | 08/11/2014 |
| US | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Granted | 13/378,618 | 12/15/2011 | 20120190086A1 | 8796002 | 08/05/2014 |
| US | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Granted | 14/313465 | 06/24/2014 | 20140308732 | 9029112 | 05/12/2015 |
| US | KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS | Pending | 14/697262 | 04/27/2015 | | | |
| EP | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | Published | 10810597.4 | 03/15/2012 | 2467473 | | |
| IN | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | Published | | 03/15/2012 | 2372/CHENP/2012 A | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | Allowed | 13/390,677 | 02/15/2012 | 20120149073 | | |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | Published | 201201086-4 | 02/16/2012 | 178456 | | |
CODEXIS CONFIDENTIAL INFORMATION
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| | | | | | | | | | | | | | | | | | | | | | | |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | Published | 10201405022P | 08/19/2014 | 10201405022P | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PREPARATION OF PHENYLEPHRINE | Pending | 14/755056 | 06/30/2015 | | | |
| CN | TRANSAMINASE REACTIONS | Allowed | 201080027740.4 | 12/21/2011 | 102597226 | | |
| EP | TRANSAMINASE REACTIONS | Published | 10797544.3 | 12/22/2011 | 2446026 | | |
| IN | TRANSAMINASE REACTIONS | Published | 9683/CHENP/2011 | 12/22/2011 | 9683/CHENP/2011 | | |
| SG | TRANSAMINASE REACTIONS | Published | 201109536-1 | 12/21/2011 | 177329 | | |
| US | TRANSAMINASE REACTIONS | Granted | 13/378,963 | 04/09/2012 | 20120190085A1 | 8921079 | 12/30/2014 |
| IL | TRANSAMINASE REACTIONS | Pending | 216099 | 11/02/2011 | | | |
| US | TRANSAMINASE REACTIONS | Published | 14/547339 | 11/19/2014 | 20150079640 | | |
| US | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 12/490,190 | 06/23/2009 | 20100063300A1 | 8178333 | 05/15/2012 |
| CN | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 200980133157.9 | 06/23/2009 | 102131813 | ZL200980133157.9 | 07/30/2014 |
| SG | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 201009300-3 | 06/23/2009 | | 167392 | 08/15/2013 |
| EP | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| IN | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Published | 397/CHENP/2011 | 01/19/2011 | 397/CHENP/2011 A | | |
CODEXIS CONFIDENTIAL INFORMATION
-3-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | STEREOMERICALLY PURE FUSED BICYLIC PROLINE COMPOUNDS USEFUL FOR PREPARING HEPATITIS C PROTEASE INHIBITORS | Granted | 13/294,930 | 11/11/2011 | 20120130087 | 8859784 | 10/14/2014 |
| US | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 13/436,506 | 03/30/2012 | 20120244581 | 8574876 | 11/05/2013 |
| FR | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| DE | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 602009019988.9 | 11/06/2013 |
| IE | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| IT | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| NL | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| ES | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| CH | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
CODEXIS CONFIDENTIAL INFORMATION
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| | | | | | | | | | | | | | | | | | | | | | | |
| GB | BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS | Granted | 9798485.0 | 06/23/2009 | 2307419 | 2307419 | 11/06/2013 |
| US | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 12/545,761 | 08/21/2009 | 20100055751A1 | 8288131 | 10/16/2012 |
| US | POLYNUCLEOTIEDES ENCODING ENGINEERED KETOREDUCTASE POLYPEPTIDES | Granted | 13/610,723 | 09/11/2012 | 20130005018A1 | 8455230 | 06/04/2013 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | Granted | 12/549,154 | 08/27/2009 | US2010-0151534-A1 | 8426178 | 04/23/2013 |
| EP | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | Allowed | 9810573.7 | 08/27/2009 | 2329013 | | |
| IN | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | Published | 2014/CHENP/2011 | 03/22/2011 | 2014/CHENP/2011 A | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | Granted | 13/796985 | 03/12/2013 | US-2013-0177962-A1 | 8673607 | 03/18/2014 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOLYL]-4PHENYL1,3-OXAZOLIDIN-2-ONE | Granted | 12/545,034 | 08/20/2009 | 20100062499A1 | 8273554 | 09/25/2012 |
CODEXIS CONFIDENTIAL INFORMATION
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| | | | | | | | | | | | | | | | | | | | | | | |
| CN | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 200980141486.8 | 04/19/2011 | 102186972 | ZL200980141486.8 | 08/20/2014 |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 201101090-7 | 02/16/2011 | | 168980 | 08/19/2014 |
| EP | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
| IN | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Published | 2000/CHENP/2011 | 03/22/2011 | 2000/CHENP/2011 | | |
| US | POLYNUCLEOTIDES ENCODING RECOMBINANT KETOREDUCTASE POLYPEPTIDES | Granted | 13/590,882 | 08/21/2012 | 20120322136A1 | 8415126 | 04/09/2013 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOLYL]-4PHENYL1,3-OXAZOLIDIN-2-ONE | Granted | 13/764596 | 02/11/2013 | US-2013-0210098-A1 | 8956840 | 02/17/2015 |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Published | 10201404330V | 07/23/2014 | 10201404330V | | |
CODEXIS CONFIDENTIAL INFORMATION
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| | | | | | | | | | | | | | | | | | | | | | | |
| FR | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
| DE | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 602009027373.6 | 10/22/2014 |
| HU | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
| NL | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
| SI | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
| CH | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
CODEXIS CONFIDENTIAL INFORMATION
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| | | | | | | | | | | | | | | | | | | | | | | |
| GB | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4PHENYL-1,3-OXAZOLIDIN-2-ONE | Granted | 9810477.1 | 03/29/2011 | 2329014 | 2329014 | 10/22/2014 |
| US | KETOREDUCTASE POLYPEPTIDES | Allowed | 14/606127 | 01/27/2015 | 20150132806 | | |
| US | ENONE REDUCTASES | Granted | 12/646,907 | 12/23/2009 | 20100190218A1 | 8329438 | 12/11/2012 |
| EP | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 2382308 | 03/04/2015 |
| IN | ENONE REDUCTASES | Published | 4505/CHENP/2011 | 12/23/2009 | 4505/CHENP/2011 | | |
| SG | ENONE REDUCTASES | Granted | 201104630-7 | 12/23/2009 | 172783 | 172783 | 09/03/2014 |
| US | ENONE REDUCTASES | Granted | 13/658,582 | 10/23/2012 | US/2013-0115663-A1 | 8883475 | 11/11/2014 |
| US | ENONE REDUCTASES | Allowed | 14/504558 | 10/02/2014 | 20150031095 | | |
| FR | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 2382308 | 03/04/2015 |
| DE | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 602009029867.4 | 03/04/2015 |
| IE | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 2382308 | 03/04/2015 |
| NL | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 2382308 | 03/04/2015 |
| CH | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 2382308 | 03/04/2015 |
| GB | ENONE REDUCTASES | Granted | 9835878.1 | 12/23/2009 | 2382308 | 2382308 | 03/04/2015 |
| US | ENONE REDUCTASES | Pending | 14/800306 | 07/15/2015 | | | |
| US | RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES | Granted | 12/642,586 | 12/18/2009 | US2010-0173372A1 | 8187856 | 05/29/2012 |
| IN | RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES | Published | 5068/CHENP/2011 | 12/18/2009 | 5068/CHENP/2011A | | |
| US | RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES | Granted | 13/452,328 | 04/20/2012 | 20120220002 | 8580555 | 11/12/2013 |
| US | PENICILLIN G ACYLASES | Granted | 12/615,139 | 11/09/2009 | US-2010-0143968-A1 | 8247192 | 08/21/2012 |
| US | PENICILLIN G ACYLASES | Granted | 13/542,835 | 07/06/2012 | 20120270282A1 | 8569013 | 10/29/2013 |
| US | NITRILASE BIOCATALYSTS | Granted | 13/381,155 | 12/28/2011 | 20120142063 | 8614081 | 12/24/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-8-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | Granted | 12/549,293 | 08/27/2009 | US2010-0173369A1 | 8288141 | 10/16/2012 |
| US | POLYNUCLEOTIDES ENCODING ENGINEERED KETOREDUCTASE POLYPEPTIDES | Granted | 13/610,166 | 09/11/2012 | 20130005017A1 | 8877475 | 11/04/2014 |
| US | POLYNUCLEOTIDES ENCODING ENGINEERED KETOREDUCTASE POLYPEPTIDES | Published | 14/503578 | 10/01/2014 | 20150031094 | | |
| CN | SYNTHESIS OF PRAZOLE COMPOUNDS | Granted | 201080054980.3 | 06/04/2012 | 102884178 | 201080054980.3 | 12/03/2014 |
| EP | SYNTHESIS OF PRAZOLE COMPOUNDS | Published | 10836590.9 | 07/05/2012 | 2510089 | | |
| IN | SYNTHESIS OF PRAZOLE COMPOUNDS | Published | 5934/CHENP/2012 | 07/05/2012 | 5934/CHENP/2012 | | |
| SG | SYNTHESIS OF PRAZOLE COMPOUNDS | Granted | 201204152-1 | 06/06/2012 | 181535 | 181535 | 01/22/2015 |
| US | SYNTHESIS OF PRAZOLE COMPOUNDS | Granted | 13/514,750 | 06/08/2012 | 20130017580A1 | 8895271 | 11/25/2014 |
| US | SYNTHESIS OF PRAZOLE COMPOUNDS | Published | 14/528708 | 10/30/2014 | 20150056668 | | |
| EP | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 11778262.3 | 12/03/2012 | 2566497 | 2566497 | 07/29/2015 |
| IN | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Published | 10077/CHENP/2012 | 11/30/2012 | 10077/CHENP/2012 | | |
| US | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 13/695,856 | 11/02/2012 | US20130052699 | 9040262 | 05/26/2015 |
| US | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Pending | 14/692964 | 04/22/2015 | | | |
| DE | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 11778262.3 | 12/03/2012 | 2566497 | 2566497 | 07/29/2015 |
| FR | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 11778262.3 | 12/03/2012 | 2566497 | 2566497 | 07/29/2015 |
| GB | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 11778262.3 | 12/03/2012 | 2566497 | 2566497 | 07/29/2015 |
CODEXIS CONFIDENTIAL INFORMATION
-9-
| | | | | | | | | | | | | | | | | | | | | | | |
| IE | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 11778262.3 | 12/03/2012 | 2566497 | 2566497 | 07/29/2015 |
| HU | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | Granted | 11778262.3 | 12/03/2012 | 2566497 | 2566497 | 07/29/2015 |
| US | PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM | Granted | 13/577,772 | 10/16/2012 | 2013/0029385 | 9080192 | 07/14/2015 |
| IN | PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM | Published | 7740/CHENP/2012 | 09/07/2012 | 7740/CHENP/2012 | | |
| US | PROCESSES USING AMINO ACID DEHYDROGENASES AND KETOREDUCTASE-BASED COFACTOR REGENERATING SYSTEM | Pending | 14/742215 | 06/17/2015 | | | |
| SG | STRUCTURE-ACTIVITY RELATIONSHIPS | Published | 201200817-3 | 02/12/2001 | 178753 | | |
| US | STRUCTURE-ACTIVITY RELATIONSHIPS | Published | 13/757554 | 02/01/2013 | 2013/0165341 | | |
| US | STRUCTURE-ACTIVITY RELATIONSHIPS | Published | 14/662541 | 03/19/2015 | 2015/0191767 | | |
| CN | KETOREDUCTASES AND USES THEREOF | Granted | 200880004582.3 | 02/08/2008 | CN 101627116A | ZL2008 8 0004582.3 | 07/10/2013 |
| SG | KETOREDUCTASES AND USES THEREOF | Granted | 200904674-9 | 02/08/2008 | | 154045 | 03/30/2012 |
| KR | KETOREDUCTASES AND USES THEREOF | Granted | 10-2009-7016084 | 02/08/2008 | | 1502634 | 03/09/2015 |
| US | KETOREDUCTASES AND USES THEREOF | Granted | 12/028,780 | 02/08/2008 | 2008/0318295 | 7820421 | 10/26/2010 |
| EP | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| IL | KETOREDUCTASES AND USES THEREOF | Pending | 199399 | 02/08/2008 | | | |
| JP | KETOREDUCTASES AND USES THEREOF | Published | 2009-549110 | 02/08/2008 | 2010-517574 | | |
CODEXIS CONFIDENTIAL INFORMATION
-10-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | KETOREDUCTASES AND USES THEREOF | Granted | 12/881,734 | 09/14/2010 | 2011/0165670A1 | 8071347 | 12/06/2011 |
| CH | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| DE | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| FR | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| GB | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| IE | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| NL | KETOREDUCTASES AND USES THEREOF | Granted | 8725329.0 | 02/08/2008 | 2115130 | 2115130 | 08/03/2011 |
| US | KETOREDUCTASES AND USES THEREOF | Granted | 13/290,773 | 11/07/2011 | 2012/0178142 | 8415127 | 04/09/2013 |
| US | KETOREDUCTASES AND USES THEREOF | Granted | 13/793158 | 03/11/2013 | 2013/0196408 | 8980605 | 03/17/2015 |
| JP | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 2007-526267 | 06/04/2005 | | 5042831 | 07/20/2012 |
| DE | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 102004029112.8 | 06/11/2004 | | 1763577 | 10/06/2010 |
| EP | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 5756002.1 | 06/04/2005 | 1763577 | 1763577 | 10/06/2010 |
| US | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 11/629,000 | 12/08/2006 | 2009/0162893 | 7,943,356 | 05/17/2011 |
CODEXIS CONFIDENTIAL INFORMATION
-11-
| | | | | | | | | | | | | | | | | | | | | | | |
| GB | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 5756002.1 | 06/04/2005 | 1763577 | 1763577 | 10/06/2010 |
| IT | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 5756002.1 | 06/04/2005 | 1763577 | 1763577 | 10/06/2010 |
| AT | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 5756002.1 | 06/04/2005 | 1763577 | 1763577 | 10/06/2010 |
| FR | ALCOHOL DEHYDROGENASE FOR THE STEREOSELECTIVE PRODUCTION OF HYDROXY COMPOUNDS | Granted | 5756002.1 | 06/04/2005 | 1763577 | 1763577 | 10/06/2010 |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 201000745-8 | 08/24/2008 | | 159008 | 09/14/2012 |
| IN | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Pending | 1624/CHENP/2010 | 08/24/2008 | | | |
| EP | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 2195443 | 01/07/2015 |
| CN | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 200880104011.7 | 08/24/2008 | 101784669 | ZL200880104011.7 | 02/18/2015 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 12/197,286 | 08/24/2008 | 2009/0093031 | 7977078 | 07/12/2011 |
CODEXIS CONFIDENTIAL INFORMATION
-12-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 13/110,789 | 05/18/2011 | 2011/0217754 | 8,227,229 | 07/24/2012 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 13/525,048 | 06/15/2012 | 2012/0276599A1 | 8962285 | 02/24/2015 |
| DE | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 602008036257.4 | 01/07/2015 |
| FR | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 2195443 | 01/07/2015 |
| IE | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 2195443 | 01/07/2015 |
| NL | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 2195443 | 01/07/2015 |
| CH | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 2195443 | 01/07/2015 |
| GB | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Granted | 8798570.1 | 08/24/2008 | 2195443 | 2195443 | 01/07/2015 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE | Published | 14/597996 | 01/15/2015 | 2015/0125910 | | |
| CN | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 200880115770.3 | 09/13/2008 | 101855342 | ZL 2008 8 0115770.3 | 07/10/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-13-
| | | | | | | | | | | | | | | | | | | | | | | |
| JP | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Published | 2010-525057 | 09/13/2008 | 2010-538657 | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 12/210,195 | 09/13/2008 | 2009/0191605 | 8748143 | 06/10/2014 |
| IN | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Pending | 2039/CHENP/2010 | 09/13/2008 | | | |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 201001576-6 | 09/13/2008 | | 159828 | 04/13/2012 |
| EP | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 2198018 | 11/20/2013 |
| KR | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Pending | 10-2010-7007675 | 09/13/2008 | | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 13/682,600 | 11/20/2012 | 2013/0078692 | 8512973 | 08/20/2013 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 13/970284 | 08/19/2013 | 2013/0344552 | 8852909 | 10/07/2014 |
| DE | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 602008028883.8 | 11/20/2013 |
| FR | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 2198018 | 11/20/2013 |
| CH | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 2198018 | 11/20/2013 |
| GB | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 2198018 | 11/20/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-14-
| | | | | | | | | | | | | | | | | | | | | | | |
| IE | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 2198018 | 11/20/2013 |
| NL | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Granted | 8830789.7 | 09/13/2008 | 2198018 | 2198018 | 11/20/2013 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Published | 14/501416 | 09/30/2014 | 2015/0017695 | | |
| JP | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Published | 2015-21874 | 02/06/2015 | 2015-91269 | | |
| SG | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 201001902-4 | 09/28/2008 | | 160022 | 07/31/2013 |
| US | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 12/240,986 | 09/29/2008 | 2009/0155863 | 8088610 | 01/03/2012 |
| CN | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 200880118039.6 | 09/28/2008 | 101889081 | ZL200880118039.6 | 06/18/2014 |
| EP | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 8833139.2 | 09/28/2008 | 2203557 | 2203557 | 02/29/2012 |
| IN | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Pending | 2378/CHENP/2010 | 09/28/2008 | | | |
| IL | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 204331 | 09/28/2008 | | 204331 | 07/31/2013 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (S,3)-METHYL2-(3-(3-(2(7-CHLOROQUINOLIN-2-YL)VINYL)PHENYL)-3-HYDROXYPROPYL)BENZOATE | Granted | 13/329,986 | 12/19/2011 | 2012/0184000 | 8617853 | 12/31/2013 |
| DE | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 8833139.2 | 09/28/2008 | 2203557 | 2203557 | 02/29/2012 |
| IE | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 8833139.2 | 09/28/2008 | 2203557 | 2203557 | 02/29/2012 |
| NL | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 8833139.2 | 09/28/2008 | 2203557 | 2203557 | 02/29/2012 |
CODEXIS CONFIDENTIAL INFORMATION
-15-
| | | | | | | | | | | | | | | | | | | | | | | |
| CH | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 8833139.2 | 09/28/2008 | 2203557 | 2203557 | 02/29/2012 |
| GB | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | Granted | 8833139.2 | 09/28/2008 | 2203557 | 2203557 | 02/29/2012 |
| EP | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL | Published | 11846568.1 | 07/14/2013 | 2649187 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| US | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL | Published | 13/992,138 | 06/06/2013 | 2013-0260426A1 | | |
| EP | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL | Published | 11796441.1 | 12/17/2012 | 2582799 | | |
| IN | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL | Published | 267/CHENP/2013 | 01/11/2013 | 267/CHENP/2013 | | |
| US | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL | Granted | 13/704507 | 12/14/2012 | 20130089898A1 | 8852900 | 10/07/2014 |
| US | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL | Granted | 14/463332 | 08/19/2014 | 20140356944 | 8932838 | 01/13/2015 |
| EP | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Granted | 11818555.2 | 04/29/2013 | 2606139 | 2606139 | 07/15/2015 |
CODEXIS CONFIDENTIAL INFORMATION
-16-
| | | | | | | | | | | | | | | | | | | | | | | |
| IN | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Published | 2013/CHENP/2013 | 03/13/2013 | 2013/CHENP/2013 | | |
| US | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Granted | 13/817295 | 03/12/2013 | US-2013-0164794-A1 | 8932836 | 01/13/2015 |
| DE | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Granted | 11818555.2 | 04/29/2013 | 2606139 | 2606139 | 07/15/2015 |
| FR | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Granted | 11818555.2 | 04/29/2013 | 2606139 | 2606139 | 07/15/2015 |
| GB | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Granted | 11818555.2 | 04/29/2013 | 2606139 | 2606139 | 07/15/2015 |
| IE | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXANAMINE | Granted | 11818555.2 | 04/29/2013 | 2606139 | 2606139 | 07/15/2015 |
| SG | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 201001989-1 | 10/01/2008 | | 160517 | 05/05/2014 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 12/243,968 | 10/01/2008 | US2009/0162909 | 7883879 | 02/08/2011 |
| EP | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| IL | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 204379 | 10/01/2008 | | 204379 | 10/01/2014 |
| JP | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 2010-527257 | 10/01/2008 | | 5646328 | 11/14/2014 |
| IN | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Pending | 2450/CHENP/2010 | 10/01/2008 | | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 12/977,825 | 12/23/2010 | 20110159567A1 | 8257952 | 09/04/2012 |
CODEXIS CONFIDENTIAL INFORMATION
-17-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 13/569,900 | 08/08/2012 | 20130034895 | 8470572 | 06/25/2013 |
| US | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 13/925096 | 06/24/2013 | 2014/0057330 | 8980606 | 03/17/2015 |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| FR | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| DE | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 602008038717.8 | 06/24/2015 |
| HU | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| IT | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| NL | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| SI | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| ES | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| GB | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF AZETIDINONE | Granted | 8836133.2 | 10/01/2008 | 2205727 | 2205727 | 06/24/2015 |
| EP | BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF | Published | 12771861.7 | 11/06/2013 | 2697662 | | |
CODEXIS CONFIDENTIAL INFORMATION
-18-
| | | | | | | | | | | | | | | | | | | | | | | |
| IN | BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF | Published | 7967/CHENP/2013 | 10/01/2013 | 7967/CHENP/2013 | | |
| US | BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF | Allowed | 14/110964 | 12/05/2013 | 20140199735 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| US | BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS | Published | 14/399034 | 11/05/2014 | 20150118719 | | |
| CN | BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS | Published | 2013800362951 | 01/07/2015 | 104428412 | | |
| EP | BIOCATALYSTS AND METHODS FOR HYDROXYLATION OF CHEMICAL COMPOUNDS | Published | 13788385.6 | 12/08/2014 | 2847327 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| EP | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF SUBSTITUTED LACTAMS | Published | 12769209.3 | 03/31/2014 | 2753640 | | |
| US | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF SUBSTITUTED LACTAMS | Allowed | 14/342713 | 03/04/2014 | 2014/0342412 | | |
| CN | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF SUBSTITUTED LACTAMS | Published | 2012800547455 | 05/07/2014 | 103998461 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
CODEXIS CONFIDENTIAL INFORMATION
-19-
| | | | | | | | | | | | | | | | | | | | | | | |
| CN | BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES | Published | 2012800673299 | 07/17/2014 | CN104053771 | | |
| EP | BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES | Published | 12795954.2 | 06/06/2014 | 2780448 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| US | BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES | Allowed | 14/357964 | 05/13/2014 | 20140322769 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| CN | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | Published | 2013800265947 | 11/21/2014 | 104508126 | | |
| EP | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | Published | 13765270.7 | 10/23/2014 | 2828385 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
CODEXIS CONFIDENTIAL INFORMATION
-20-
| | | | | | | | | | | | | | | | | | | | | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| US | BIOCATALYSTS AND METHODS FOR SYNTHESIZING DERIVATIVES OF TRYPTAMINE AND TRYPTAMINE ANALOGS | Allowed | 14/386082 | 09/18/2014 | 20150072383 | | |
| US | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | Published | 13/890944 | 05/09/2013 | 20130302859A1 | | |
| EP | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | Published | 13724127.9 | 12/08/2014 | 2847214 | | |
| CN | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | Published | 2013800370394 | 01/12/2015 | 104428313 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
CODEXIS CONFIDENTIAL INFORMATION
-21-
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CODEXIS CONFIDENTIAL INFORMATION
-22-
| | | | | | | | | | | | | | | | | | | | | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| WO | ENGINEERED TRANSAMINASE POLYPEPTIDES FOR INDUSTRIAL BIOCATALYSIS | Published | PCT/US2014/018005 | 02/24/2014 | WO2014/133960 | | |
| US | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | Published | 14/539690 | 11/12/2014 | 20150132807 | | |
| WO | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | Published | PCT/US2014/065259 | 11/12/2014 | WO2015/073555 | | |
| [***] | [***] | [***] | [***] | [***] | | | |
| [***] | [***] | [***] | [***] | [***] | | | |
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| [***] | [***] | [***] | [***] | [***] | | | |
| IN | IMPROVED KETOREDUCTASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 514/CHENP/2006 | 08/11/2004 | | 239120 | 03/09/2010 |
CODEXIS CONFIDENTIAL INFORMATION
-23-
| | | | | | | | | | | | | | | | | | | | | | | |
| SG | IMPROVED KETOREDUCTASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 200600860-1 | 08/11/2004 | | 119648 | 12/31/2008 |
| US | KETOREDUCTASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 10/916,311 | 08/11/2004 | 20060195947A1 | 7629157 | 12/08/2009 |
| US | KETOREDUCTASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 12/576,195 | 10/08/2009 | 20100028972A1 | 7833767 | 11/16/2010 |
| EP | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 3785237.3 | 08/11/2003 | 1537222 | 1537222 | 03/09/2011 |
| US | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 11/502,745 | 08/10/2006 | 20070161094A1 | 7807423 | 10/05/2010 |
| US | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES AND VICINAL CYANO, HYDROXY SUBSTITUTED CARBOXYLIC ACID ESTERS | Granted | 10/782,258 | 02/18/2004 | US 2004-0214297 A1 | 7132267 | 11/07/2006 |
| US | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 10/639,159 | 08/11/2003 | US 2004-0137585 A1 | 7125693 | 10/24/2006 |
| IN | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYR1C ACID DERIVATIVES | Granted | 158/CHENP/2005 | 08/11/2003 | | 220964 | 06/11/2008 |
| SG | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 2005007634-8 | 08/11/2003 | | 109875 | 08/31/2007 |
| SG | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-RYDROXYBUTYRIC ACID DERIVATIVES AND VICINAL CYANO, HYDROXY SUBSTITUTED CARBOXYLIC ACID ESTERS | Granted | 200600847-8 | 02/18/2004 | | 119636 | 02/29/2008 |
| JP | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 2004-528083 | 08/11/2003 | 2005-535330 | 4578240 | 09/03/2010 |
CODEXIS CONFIDENTIAL INFORMATION
-24-
| | | | | | | | | | | | | | | | | | | | | | | |
| HK | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 5108017.7 | 08/11/2003 | | HK1074059 | 09/09/2011 |
| FR | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 3785237.3 | 08/11/2003 | 1537222 | 1537222 | 03/09/2011 |
| DE | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 3785237.3 | 08/11/2003 | 1537222 | 1537222 | 03/09/2011 |
| IE | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 3785237.3 | 08/11/2003 | 1537222 | 1537222 | 03/09/2011 |
| NL | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 3785237.3 | 08/11/2003 | 1537222 | 1537222 | 03/09/2011 |
| GB | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | Granted | 3785237.3 | 08/11/2003 | 1537222 | 1537222 | 03/09/2011 |
| SG | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 200600859-3 | 08/11/2004 | | 119647 | 02/27/2009 |
| US | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 12/790,784 | 05/28/2010 | US20100304459 | 7939309 | 05/10/2011 |
| IN | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 521/CHENP/2006 | 08/11/2004 | | 239922 | 04/09/2010 |
| AU | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 2004288134 | 08/11/2004 | | 2004288134 | 04/01/2010 |
| US | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 10/915,927 | 08/11/2004 | 20050095619A1 | 7816111 | 10/19/2010 |
| EP | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 1660648 | 10/09/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-25-
| | | | | | | | | | | | | | | | | | | | | | | |
| FR | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 1660648 | 10/09/2013 |
| DE | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 602004043547.3 | 10/09/2013 |
| IE | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 1660648 | 10/09/2013 |
| NL | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 1660648 | 10/09/2013 |
| CH | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 1660648 | 10/09/2013 |
| GB | IMPROVED GLUCOSE DEHYDROGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES | Granted | 4816807.4 | 08/11/2004 | 1660648 | 1660648 | 10/09/2013 |
| US | HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 12/573,824 | 10/05/2009 | US2010-0167345A1 | 8101395 | 01/24/2012 |
| US | HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 10/917,179 | 08/11/2004 | 20050153417A1 | 7824898 | 11/02/2010 |
| IN | IMPROVED HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 519/CHENP/2006 | 08/11/2004 | | 239852 | 04/06/2010 |
| SG | IMPROVED HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 200808477-4 | 11/14/2008 | 148180 | 148180 | 01/30/2014 |
| US | IMPROVED HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 11/266,747 | 11/02/2005 | 20060099700A1 | 7588928 | 09/15/2009 |
| US | IMPROVED HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 11/067,323 | 02/23/2005 | US 2005-0272064 A1 | 7541171 | 06/02/2009 |
| US | IMPROVED HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 12/505,374 | 07/17/2009 | 20090298125A1 | 8252554 | 08/28/2012 |
CODEXIS CONFIDENTIAL INFORMATION
-26-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES | Granted | 13/349,514 | 01/12/2012 | US20120208259A1 | 8535910 | 09/17/2013 |
| US | ALANINE 2,3-AMINOMUTASES AND RELATED POLYNUCLEOTIDES | Granted | 11/919,271 | 03/20/2009 | 20100099143A1 | 7790432 | 09/07/2010 |
| IN | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Pending | 2322/CHENP/2009 | 10/01/2007 | | | |
| SG | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 200901677-5 | 10/01/2010 | | 150849 | 01/30/2014 |
| EP | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 7843631.8 | 10/01/2007 | 2066788 | 2066788 | 07/23/2014 |
| CN | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Allowed | 200780036841.6 | 10/01/2007 | 101528917 | | |
| US | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 11/865696 | 10/01/2007 | 248539 | 7879585 | 02/01/2011 |
| US | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 12/978,022 | 12/23/2010 | US20110195465A1 | 8273547 | 09/25/2012 |
| US | POLYNUCLEOTIDES ENCODING KETOREDUCTASES FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 13/571,248 | 08/09/2012 | 20130040364 | 8617864 | 12/31/2013 |
| FR | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 7843631.8 | 10/01/2007 | 2066788 | 2066788 | 07/23/2014 |
CODEXIS CONFIDENTIAL INFORMATION
-27-
| | | | | | | | | | | | | | | | | | | | | | | |
| DE | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 7843631.8 | 10/01/2007 | 2066788 | 602007037820.6 | 07/23/2014 |
| GB | COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR | Granted | 7843631.8 | 10/01/2007 | 2066788 | 2066788 | 07/23/2014 |
| US | ENZYMATIC CONVERSION OF EPDXIDES | Granted | 11/833,933 | 08/03/2007 | US2008/0220485 | 7695942 | 04/13/2010 |
CODEXIS CONFIDENTIAL INFORMATION
-28-
Exhibit 1.29
Codexis Mayflower Patents
Attached.
EXHIBIT 1.29
| | | | | | | | | | | | | | | | | | | | | | | |
| CODEXIS MAYFLOWER PATENTS |
| Country | Application Title | Application Status | Application Number | Filing Date | Publication Number | Patent Number | Issue Date |
| US | EVOLVING CELLULAR DNA UPTAKE BY RECURSIVE SEQUENCE RECOMBINATION | GRANTED | 08/792409 | 02/03/1997 | | 6096548 | 08/01/2000 |
| US | EVOLVING CELLULAR DNA UPTAKE BY RECURSIVE SEQUENCE RECOMBINATION | GRANTED | 09/430927 | 11/01/1999 | | 6358742 | 03/19/2002 |
| US | METHOD FOR PRODUCING POLYNUCLEOTIDES WITH DESIRED PROPERTIES | GRANTED | 09/333762 | 06/15/1999 | | 6337186 | 01/08/2002 |
| US | HIGH THROUGHPUT MASS SPECTROMETRY | GRANTED | 09/502,283 | 02/11/2000 | | 7384387 | 06/10/2008 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 11/339090 | 01/24/2006 | 142950 | 7620502 | 11/17/2009 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 11/975638 | 10/18/2007 | 50782 | 7853410 | 12/14/2010 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 12/557463 | 09/10/2009 | 56385 | 7957912 | 06/07/2011 |
CODEXIS CONFIDENTIAL INFORMATION
-1-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 11/982405 | 10/31/2007 | 318795 | 7904249 | 03/08/2011 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 09/618579 | 07/18/2000 | | 7024312 | 04/04/2006 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 09/539486 | 03/30/2000 | | 7058515 | 06/06/2006 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 09/494282 | 01/18/2000 | 183934 | 6917882 | 07/12/2005 |
| US | METHODS OF MAKING CHARACTER STRINGS, POLYNUCLEOTIDES & POLYPEPTIDES HAVING DESIRED CHARACTERISTICS | GRANTED | 11/075231 | 03/07/2005 | 191688 | 7421347 | 09/02/2008 |
| US | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 09/626929 | 07/27/2000 | | 6319714 | 11/20/2001 |
| GB | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| US | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 09/694863 | 10/23/2000 | | 6521453 | 02/18/2003 |
| US | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 11/987555 | 11/30/2007 | 171668 | 8029988 | 10/04/2011 |
| US | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 12/557829 | 09/11/2009 | 184627 | 8058001 | 11/15/2011 |
CODEXIS CONFIDENTIAL INFORMATION
-2-
| | | | | | | | | | | | | | | | | | | | | | | |
| CA | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 2320697 | 01/18/2000 | 2320697 | 2320697 | 11/18/2014 |
| US | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 09/626595 | 07/27/2000 | | 6479652 | 11/12/2002 |
| EP | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| EP | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | ALLOWED | 10075153.6 | 01/18/2000 | 2253704 | | |
| BE | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| DK | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| FR | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| DE | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| NL | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| CH | OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION | GRANTED | 909923.5 | 01/18/2000 | 1072010 | 1072010 | 04/21/2010 |
| US | RECOMBINATION OF INSERTION MODIFIED NUCLEIC ACIDS | GRANTED | 09/723520 | 11/27/2000 | | 6413745 | 07/02/2002 |
| US | RECOMBINATION OF INSERTION MODIFIED NUCLEIC ACIDS | GRANTED | 09/723473 | 11/27/2000 | | 6358740 | 03/19/2002 |
| US | RECOMBINATION OF INSERTION MODIFIED NUCLEIC ACIDS | GRANTED | 09/517933 | 03/03/2000 | | 6365377 | 04/02/2002 |
| US | OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION | GRANTED | 12/557434 | 09/10/2009 | 70192 | 8108150 | 01/31/2012 |
| US | OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION | GRANTED | 11/818237 | 06/12/2007 | 20397 | 8224580 | 07/17/2012 |
CODEXIS CONFIDENTIAL INFORMATION
-3-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION | GRANTED | 10/386903 | 03/10/2003 | 198988 | 7620500 | 11/17/2009 |
| EP | OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION | PUBLISHED | 3711540.9 | 03/10/2003 | 1488335 | | |
| US | INTEGRATED SYSTEMS AND METHODS FOR DIVERSITY GENERATION AND SCREENING | GRANTED | 11/677505 | 02/21/2007 | 15116 | 8014961 | 09/06/2011 |
| US | INTEGRATED SYSTEMS AND METHODS FOR DIVERSITY GENERATION AND SCREENING | GRANTED | 10/154936 | 05/23/2002 | 54383 | 7462469 | 12/09/2008 |
| US | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS | GRANTED | 12/557746 | 09/11/2009 | 241640 | 8170806 | 05/01/2012 |
| US | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS | GRANTED | 11/973805 | 10/09/2007 | 40045 | 7873499 | 01/18/2011 |
| US | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS | GRANTED | 11/210239 | 08/22/2005 | 47611 | 7430477 | 09/30/2008 |
| US | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS | GRANTED | 09/495668 | 02/01/2000 | 32010 | 6961664 | 11/01/2005 |
| CA | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS | GRANTED | 2337949 | 01/18/2000 | 2337949 | 2337949 | 03/15/2011 |
| US | METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONS | GRANTED | 13/434261 | 03/29/2012 | 20120252684A1 | 8589085 | 11/19/2013 |
| US | METHOD AND SYSTEM USING SYSTEMATICALLY VARIED DATA LIBRARIES | GRANTED | 10/225564 | 08/20/2002 | | 7873477 | 01/18/2011 |
CODEXIS CONFIDENTIAL INFORMATION
-4-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | METHOD AND APPARATUS FOR PREFERREED CODON DETERMINING SIMULATIONS | GRANTED | 10/232770 | 08/30/2002 | | 7702464 | 04/20/2010 |
| US | METHOD AND APPARATUS FOR PREFERREED CODON DETERMINING SIMULATIONS | GRANTED | 13/229228 | 09/09/2011 | | 8457903 | 06/04/2013 |
| EP | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | PUBLISHED | 12/979,637 | 12/28/2010 | 20110161265 | | |
| JP | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 2003-573522 | 03/03/2003 | | 5319865 | 07/19/2013 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 11/981577 | 10/30/2007 | 133143 | 7751986 | 07/06/2010 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 11/706034 | 02/12/2007 | 239364 | 7747393 | 06/29/2010 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 11/429628 | 05/05/2006 | 205003 | 8849575 | 09/30/2014 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10/629351 | 07/29/2003 | 161796 | 7747391 | 06/29/2010 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10/379378 | 03/03/2003 | 72245 | 7783428 | 08/24/2010 |
| EP | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-5-
| | | | | | | | | | | | | | | | | | | | | | | |
| EP | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| EP | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| BE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| FR | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| GB | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| DE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| DK | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| BE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| GB | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| DE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| NL | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
CODEXIS CONFIDENTIAL INFORMATION
-6-
| | | | | | | | | | | | | | | | | | | | | | | |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | PUBLISHED | 14/256692 | 04/18/2014 | 2014/0249035 | | |
| FR | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| CH | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| DK | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181057.0 | 09/28/2010 | 2390803 | 2390803 | 11/20/2013 |
| CH | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| NL | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 5779687.2 | 06/21/2005 | 1761879 | 1761879 | 08/14/2013 |
| SE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| DK | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| FR | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| IE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| NL | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
CODEXIS CONFIDENTIAL INFORMATION
-7-
| | | | | | | | | | | | | | | | | | | | | | | |
| BE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| DE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 60346889.6 | 10/15/2014 |
| HU | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| IT | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| CH | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| GB | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 3743748.0 | 03/03/2003 | 1493027 | 1493027 | 10/15/2014 |
| DK | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| HU | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| IE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| IT | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| CH | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
CODEXIS CONFIDENTIAL INFORMATION
-8-
| | | | | | | | | | | | | | | | | | | | | | | |
| GB | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | PUBLISHED | 14/536242 | 11/07/2014 | 20150065357 | | |
| DE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 60347028.9 | 11/19/2014 |
| BE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| FR | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| NL | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| SE | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 10181000.0 | 09/28/2010 | 2278509 | 2278509 | 11/19/2014 |
| US | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | GRANTED | 11/981578 | 10/30/2007 | 132416 | 8762066 | 06/24/2014 |
| EP | METHODS, SYSTEMS AND SOFTWARE FOR IDENTIFYING FUNCTIONAL BIOMOLECULES | ALLOWED | 10181159.4 | 09/28/2010 | 2315145 | | |
CODEXIS CONFIDENTIAL INFORMATION
-9-
Exhibit 1.38
Designated Lab
[***]
Exhibit 1.60
In-License Agreements
[***]
Exhibit 1.63
In-Licensed Patents
Attached.
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| IN-LICENSED PATENTS |
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CODEXIS CONFIDENTIAL INFORMATION
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CODEXIS CONFIDENTIAL INFORMATION
-3-
Exhibit 1.97
Restricted Enzyme List
Attached.
EXHIBIT 1.97
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CODEXIS CONFIDENTIAL INFORMATION
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EXHIBIT 1.97
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EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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CODEXIS CONFIDENTIAL INFORMATION
-3-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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EXHIBIT 1.97
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EXHIBIT 1.97
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EXHIBIT 1.97
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[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
CODEXIS CONFIDENTIAL INFORMATION
-7-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
CODEXIS CONFIDENTIAL INFORMATION
-8-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
CODEXIS CONFIDENTIAL INFORMATION
-9-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
CODEXIS CONFIDENTIAL INFORMATION
-10-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
CODEXIS CONFIDENTIAL INFORMATION
-11-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
CODEXIS CONFIDENTIAL INFORMATION
-12-
EXHIBIT 1.97
RESTRICTED ENZYME LIST—Listed by Panel/Kit
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CODEXIS CONFIDENTIAL INFORMATION
-13-
Merck-Codexis Technology Transfer Plan
Exhibit 1.103
Technology Transfer Plan
Attached.
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
Technology Transfer Plan
Establishment of Codexis CodeEvolver®
Directed Evolution Technology
at Merck
Execution Version
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
| | |
| CODEXIS CONFIDENTIAL INFORMATION |
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
1. EXECUTIVE SUMMARY
The scope of this Plan is the full implementation of Codexis’ biocatalyst screening and CodeEvolver® directed evolution technology within Merck, Sharp & Dohme Corp. (“MERCK”) in order to augment MERCK’s capabilities in cost efficient development and manufacture of MERCK Developed APIs. The complete transfer of Codexis Platform Technology to MERCK will be accomplished across the following two Waves:
Wave 1: Transfer of [***] to MERCK.
Wave 2: Enabling MERCK to practice the Platform Technology comprising:
a. Set-up of the Designated Lab; including access to the Codexis Software.
b. [***] in Codexis labs in Redwood City, CA (“RWC”) [***]
c. [***] in the Designated Lab [***]
d. Training at Redwood City, CA in [***].
Codexis and MERCK will establish dedicated training Teams to facilitate the Technology Transfer. Codexis Team will include personnel for [***].
Likewise, dedicated MERCK Team will: (a) shadow Codexis Team and then conduct a Technology Transfer Project at MERCK, (b) set up and deploy equipment in MERCK’s Designated Lab, and (c) provide general program management support. [***].
2. TECHNOLOGY TRANSFER PROGRAM SCOPE
2.1 WAVE 1: TRANSFER OF codexis Screening capabilities to MERCK
[***]
[***]
[***]
• [***]
1. [***]
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
2. [***]
3. [***]
4. [***]
5. [***]
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2.2 WAVE 2: ENABLING MERCK TO PRACTICE PLATFORM TECHNOLOGY
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1) [***]
2) [***]
3) [***]
4) [***]
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CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
[***]
• [***]
1. [***]
2. [***]
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3. [***]
2. EVOLUTION PROGRAM
See Section 4.1 of Agreement. Evolution Programs must conclude within [***] from the Effective Date but shall not be considered part of Technology Transfer. Completion and/or success of Evolution Programs is not a condition to the Completion of Wave 1 or the Completion of Wave 2.
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
INDICATIVE GANTT CHART
[***]
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
3. Personnel competency requirements
Codexis will provide the following competencies to support successful technology transfer:
• [***]
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CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
APPENDIX I - TRANSFER OF MATERIALS (WAVE 1)
[***]
1) [***]
A) [***]
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| Platform | Short Name | # of 96-well Plates per Panel | # of Enzymes per Kit | Format | Quantity Provided |
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CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
2) [***]
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| Platform | Short Name | Format | Number of Enzymes | Quantity Provided |
| [***] | [***] | [***] | [***] | [***] |
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3) [***]
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[***]
CODEXIS CONFIDENTIAL INFORMATION
Merck-Codexis Technology Transfer Plan
APPENDIX II – EQUIPMENT LIST
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| Principal Equipment |
| [***] |
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CODEXIS CONFIDENTIAL INFORMATION
APPENDIX III – CODEXIS SOFTWARE LIST
• [***]
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APPENDIX IV- PROTOCOLS AND SOP LIST
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Exhibit 3.4.2
Limitations on Codexis Mayflower Patents
Merck shall have no right under the Codexis Mayflower Patents with respect to:
(a) the making, having made, using and selling of reagents, instruments and services for the diagnostics and research supply markets, only as follows: (a) clinical and diagnostic tests, including those conducted to identify genetic disease predisposition, genetic or other disease conditions, and infectious or pathogenic agents, as well as those conducted for other medical, agricultural or veterinary purposes; (b) tests for analytical/bioanalytical purposes, including those conducted for biomedical, chemical, or medical research or treatment purposes, for environmental purposes, and for forensic purposes, including paternity, maternity or identity tests; and (c) sequencing and sequence analysis of nucleic acids or other biological polymers for any purposes; but excluding (i) the use of a reagent, other than a nucleic acid array, that specifically binds to selected cells, organs or tissue, and that is sold for medical use in procedures to image selected cells, organs or tissue, which procedure is carried out inside the body of an animal or human, and that requires FDA approval, and (ii) the sale of products and performance of services requiring a license under the In-Licensed Patents, to identify compounds that bind to receptors for use as pharmaceuticals;
(b) any (i) amino acid (including any natural, synthetic, modified or other amino acid analogue) chain that is a human or humanized protein, or any variant, homology, derivative, mutant or fragment thereof, and (ii) any molecule described in subsection (i) that is conjugated or otherwise coupled to any other molecule, in each of cases (i) and (ii) expressly including (iii)(A) any amino acid (including any natural, synthetic, modified or other amino acid analogue) chain that is a cytotoxic T lymphocyte associated antigen 4 or any variant, homolog, derivative, mutant or fragment thereof, and (B) any molecule described in subsection (iii)(A) that is conjugated or otherwise coupled to any other molecule, and (iv)(A) any amino acid (including any natural, synthetic, modified or other amino acid analogue) chain that is a human or animal protein or any variant, homolog, derivative, mutant or fragment of the foregoing, and (B) any molecule described in subsection (iv)(A) that is conjugated or otherwise coupled to any other molecule, and any pharmaceutical products that contain any of the foregoing as an ingredient;
(c) any formulation containing one or more antigens (or a nucleic acid sequence encoding an Antigen) in the form of (a) an infectious agent (e.g., bacteria, viruses, parasite, protozoa) whether live, attenuated or dead, (b) protein(s), (c) nucleic acid(s), (d) cells, spores and vectors (i.e., viruses or virus-like particles, liposomes, beads or other substrates for Antigen presentation), (e) fragments of any of the foregoing, or (f) a combination of any of the preceding, which formulation is administered or is intended to be administered to induce an Antigen-Specific Response in the human or
animal recipient to at least one such antigen for the prevention of the onset of, or treatment of, a disease state, symptom or condition in humans or animals caused by an infectious agent; where “Antigen” means a molecule (e.g., protein, nucleic acid, polypeptide, peptide, carbohydrate, glycoprotein, glycolipid or any combination of the foregoing) that is produced naturally by, or is derived in whole or in part from, an infectious agent (e.g., bacteria, viruses, parasite, protozoa) that produces an Antigen-Specific Response to such molecule in a human or animal recipient (but excluding any molecule that is derived from, in whole or in part, any human gene or protein); and “Antigen-Specific Response” means an immune state resulting from the modulation of activity (i.e., an increase, decrease or qualitatively different activity) or one or more lymphoid cells (e.g., B cells, NK cells, T cells or professional antigen-presenting cells, such as monocytes, macrophages, Langerhans cells, dendritic cells) following the administration of a stimulus, where such immune state is induced in a human or animal recipient to an Antigen that is specifically directed to the subject Antigen;
(d) the development, production and/or sale of any and all polypeptides more than twelve (12) amino acids in length, and the development of organisms and vectors (including without limitation plant vectors and plant hosts) for the expression of such polypeptides, in the areas of (a) processes for textile or garment production, (b) processes for the production of leather, (c) cleaning processes or cleaning products, (d) starch processing, (e) food production processes, (f) animal feed processing, (g) personal care processes, excluding pharmaceutical products and oral, topical and intravaginal medications, (g) the processing of wood, paper, pulp and derived lignin and cellulose, (i) oil drilling, (j) dyestuffs and dyeing processes, (k) electronics industry waste water treatment, (l) detoxification of pesticides, chemical weapons and biological weapons, (m) utilization of industrial waste or co-products to generate energy, compost or industrial raw materials including fermentable substrates for e.g. citric acid production from agricultural waste, (n) polymer production, modification or processing of polymers (tetramers of higher) from monomers (including polymers made by addition of dimers or trimers for reactions proceeding to completion in the same reactor), and the enzymatic modification of chemically synthesized polymers, (o) waste water treatment, sewage sludge treatment or cleanup of contaminated soil, (p) synthesis of fuels including bio-diesel and hydrogen, and (q) bioremediation of water, soil and municipal waste, including without limitation biological waste, sewage and sludge (including without limitation biological waste treatment and cleaning of sewer and drain pipes).
(e) any and all human or humanized granulocyte-colony stimulating factor (G-CSF) protein, or any and all variants, derivatives, mutants or fragments thereof, and any and all pharmaceutical products that contain any of the foregoing.
Exhibit 3.4.4
Third Party Enzyme Supplier(s)
[***]
[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
Exhibit 4.2
Statement of Work Form
Attached.
[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
STATEMENT OF WORK NO. ____
| | | | | |
Codexis, Inc. (“Codexis”) | _______________________(“Merck”) |
| 200 Penobscot Dr. | __________________________________ |
| Redwood City, CA 94063 | __________________________________ |
| |
This Statement of Work No. (this “Statement of Work”), effective as of (the “Statement of Work Effective Date”) is made by and between Merck and Codexis and is subject to the terms and conditions of the Platform Technology Transfer and License Agreement dated as of ________________________, 2015 (“Platform Technology Transfer and License Agreement”), to which this Statement of Work is attached and incorporated therein.
I. [***]
[***]
[***]
[***]
II. [***]
[***]
[***]
III. [***]
[***]
IV. [***]
[***]
V. [***]
[***]
VI. [***]
[***]
The Parties have executed this Statement of Work by their respective duly authorized representatives on the dates identified below but the Statement of Work shall become effective as of the Statement of Work Effective Date.
CODEXIS, INC. ___________________________
By: _____________________________ By: _____________________________
Name: ___________________________ Name: __________________________
Title: ______________________________ Title: _____________________________
Date: Date:
Exhibit 4.3
Approved Subcontractors
[***]
[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.
Exhibit 10.5.1
Press Release
Attached.
Codexis Announces CodeEvolver Technology Transfer and License Agreement with Merck
Codexis to Receive $5 Million in Upfront Payment
Codexis to Hold Conference Call on [Day/Date] at [xx:xx a.m./p.m.] Eastern Time
REDWOOD CITY, Calif. (August XX, 2015) – Codexis, Inc. (NASDAQ: CDXS), a leading developer of biocatalysts for the pharmaceutical and fine chemical industries, announces the signing of a CodeEvolver® platform technology license agreement with Merck, known as MSD outside the United States and Canada, through a subsidiary. This transaction marks the second CodeEvolver licensing agreement between Codexis and a major pharmaceutical company and advances the technology’s business model of multiple sources of revenue.
Under the terms of the agreement, Codexis has granted Merck a non-exclusive license to use Codexis’ proprietary CodeEvolver protein engineering platform technology to develop novel enzymes for use in the manufacture of Merck’s pharmaceutical products. Upon completion of the technology transfer a Codexis’ CodeEvolver protein engineering platform will be located at a Merck research site.
Codexis is eligible to receive up to $18 million over approximately the next 15 to 24 months, $5 million of which will be paid upon the signing of this agreement and an additional $13 million subject to the satisfactory completion of certain technology transfer milestones. Codexis will also be eligible to receive payments of up to maximum of $15 million for each pharmaceutical ingredient (API) using novel enzymes developed by Merck using the CodeEvolver technology and used for commercial manufacturing purposes.
“This licensing transaction builds upon our productive eight-year relationship with Merck and further validates the ability of CodeEvolver to effectively and cost-efficiently improve certain manufacturing
processes,” stated John Nicols, President and CEO of Codexis. “We view licensing agreements involving our CodeEvolver technology such as this one with Merck as an attractive component of our business model. It allows us to monetize our core technology, while continuing to provide services and supply products to customers under our traditional business model.”
“This technology transfer and licensing agreement builds upon our long standing collaboration in biocatalysis with Codexis,” said Rich Tillyer, senior vice president, and head of Global Chemistry, Merck Research Laboratories. “Increased access to the CodeEvolver technology positions Merck to potentially expand upon the use of enzymes in its pharmaceutical manufacturing processes.”
Conference Call
Codexis will hold a conference call on [day/date/time] to discuss this announcement and answer questions. The conference call dial-in numbers are [phone number] for domestic callers and [phone number] for international callers, and passcode [code]. A live webcast of the call will be available on the Investors section of www.codexis.com.
A recording of the call will be available for 48 hours beginning approximately two hours after the completion of the call by dialing [phone number] for domestic callers or [phone number] for international callers. Please use the passcode [code] to access the replay. A webcast replay will be available on the Investors section of www.codexis.com for 30 days, beginning approximately two hours after the completion of the call.
About CodeEvolver® Protein Engineering Platform Technology
CodeEvolver is Codexis’ proprietary protein engineering platform, which enables rapid development of custom-designed enzymes that are highly optimized for efficient manufacturing processes. The CodeEvolver platform is comprised of proprietary methods for the optimization of proteins through the design and generation of diverse genetic libraries, automated screening techniques, algorithms for the interpretation of screening data and predictive modelling. The Codexis CodeEvolver platform technology is covered by more than 150 issued patents and pending patent applications worldwide.
About Codexis, Inc.
Codexis, Inc. is a leading protein engineering company that applies its technology to the development of biocatalysts for commercial manufacture of pharmaceuticals and fine chemicals. Codexis’ proven
technology enables implementation of biocatalytic solutions to meet customer needs for rapid, cost-effective and sustainable manufacturing. For more information, see www.codexis.com.
Forward-Looking Statements
This press release contains forward-looking statements relating to Codexis’ expectation that it will receive up to $18 million over approximately the next 15 to 24 months under the agreement, the potential for Codexis to receive product-related payments of up to $15 million for each Merck-developed API that is manufactured using one or more enzymes that have been developed using the CodeEvolver protein engineering platform technology, and the establishment of a protein engineering lab at a designated Merck research site. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond Codexis' control and that could materially affect actual results. Factors that could materially affect actual results include Codexis' dependence on its collaborators; Codexis' dependence on a limited number of products and customers; potential adverse effects to Codexis' business if its customers' pharmaceutical products are not received well in the markets; Codexis’ ability to retain key personnel; Codexis’ reliance on customers to provide timely information in order for Codexis to report its financial results in an accurate and timely fashion; Codexis’ ability to compete may decline if it loses some of its intellectual property rights; third party claims that Codexis infringes third party intellectual property rights; and Codexis could face increased competition if third parties misappropriate Codexis biocatalysts. Additional factors that could materially affect actual results can be found in Codexis' Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on March 6, 2015, including under the caption “Risk Factors,” and in Codexis’ Quarterly Report on Form 10-Q filed with the SEC on May 7, 2015. Codexis expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law.
Contact:
Investors
LHA
Jody Cain, 310-691-7100
jcain@lhai.com
Notch Communications
Kate Whelan, +46 (0)70 238 11 49
Kate.whelan@notchcommunications.co.uk
# # #
