Exhibit 99.1
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Codexis Reports Third Quarter 2022 Financial Results

Reiterates 2022 Total Revenue Guidance of $135M-$141M,
Including Product Revenues of $112M-$118M

REDWOOD CITY, Calif., November 3, 2022 -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, today announced financial results for the third quarter ended September 30, 2022 and provided a business update.

“In the last few months, the leadership team and I have been working to refine Codexis’ strategy by assessing the markets where Codexis and our proprietary CodeEvolver® platform have a clear competitive advantage,” said Dr. Stephen Dilly, President and CEO of Codexis. “We believe our evolved strategy will position the Company nicely to drive long-term success and increased market penetration by focusing our resources and concentrating our spend on programs where we are positioned to win. I look forward to sharing additional detail on the go-forward plan in the coming months as we solidify our strategy to deliver value for Codexis customers and shareholders.”

Key Business Highlights

•Product revenues decreased 2% to $28.0 million in the third quarter of 2022. Excluding revenue from sales of CDX-616 used in the manufacture of Pfizer’s COVID-19 therapeutic (PAXLOVID™) in both periods, product revenues increased 53% to $15.1 million in the third quarter of 2022, up from $9.9 million in the third quarter of 2021. Revenues attributable to enzymes sales to Pfizer for the manufacture of PAXLOVID™ were $12.9 million in the third quarter of 2022 compared to $18.9 million last year.

•Executive Leadership Updates

◦Dr. Stephen Dilly was appointed as the President and CEO of Codexis. Dr. Dilly has more than three decades of executive management experience in the biopharmaceutical industry, most recently having served as President and CEO of Sierra Oncology through its recent sale to GlaxoSmithKline for $1.9 billion.

◦Kevin Norrett was appointed as the Chief Operating Officer of Codexis. Mr. Norrett brings more than 20 years of experience across commercial, business and corporate development, operations and finance. He is responsible for driving the Company’s corporate growth strategy, business development and operational activities.

◦Margaret Fitzgerald was appointed as General Counsel of Codexis. Ms. Fitzgerald has almost two decades of legal experience in the biotechnology field, with a background spanning complex transactions, intellectual property and portfolio management, and commercializing therapeutics.

•The Company announced the appointment of Rahul Singhvi, Sc.D. to its Board of Directors. Currently the CEO of National Resilience, a technology-focused biomanufacturing company, Dr. Singhvi is a biotechnology industry veteran with more than 30 years of research and development, operations and commercialization expertise across several modalities including cell and gene therapies, nucleic acids, vaccines and biologics.

•Codexis hosted its 2022 Protein Engineering Forum, bringing over 100 top scientists and innovators together for two days of presentations and networking events to facilitate the sharing of insights and recent technological advancements throughout genomics, nucleic acid synthesis and synthetic biology.
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Third Quarter 2022 Financial Highlights

•Total revenues for the third quarter 2022 were $34.5 million, a decrease of 6% from $36.8 million in the third quarter 2021. On a segment basis, $31.1 million in revenue was from the Performance Enzymes segment and $3.3 million was from Biotherapeutics.

•Product revenues for the third quarter 2022 were $28.0 million compared to $28.7 million in the third quarter 2021; the decrease was primarily driven by lower enzyme sales related to PAXLOVID™.

•R&D revenues for the third quarter 2022 were $6.4 million compared to $8.0 million in the third quarter 2021; the decrease was driven by lower revenues from several of our large, existing customers.

•Product gross margin for the third quarter 2022 was 65% compared to 76% in the third quarter 2021. The decrease was largely driven by changes in product mix, particularly the decline in sales related to PAXLOVID, variations in prices for volume sold and higher shipping costs.

•R&D expenses for the third quarter 2022 were $21.8 million compared to $15.2 million in the third quarter 2021. The increase was primarily driven by higher costs associated with increased headcount and salaries as well as higher expenses for facilities and outside services.

•Selling, General & Administrative expenses for the third quarter 2022 were $13.5 million, compared to $13.4 million in the third quarter 2021. SG&A expenses were flat, primarily, because higher compensation-related expenses were offset by decreases in legal costs.

•The net loss for the third quarter 2022 was $10.0 million, or $0.15 per share, compared to a net income of $2.2 million, or $0.03 per share, for the third quarter 2021.

•As of September 30, 2022, the Company had $108.7 million in cash and cash equivalents.

2022 Guidance

Codexis reiterated its financial guidance for 2022 issued on July 14, 2022, as follows:

•Total revenues are expected to be in the range of $135 million to $141 million.

•Product revenues are expected to be in the range of $112 million to $118 million, including approximately $75 million from Pfizer.

•Gross margin on product revenue is expected to be in the range of 65% to 70%.

In addition, Codexis expects that its existing cash and cash equivalents, combined with the Company’s future expectations for product revenues, R&D revenues and expense management, will be sufficient to fund its planned operations through at least the end of 2024.

Conference Call and Webcast

Codexis will hold a conference call and webcast today beginning at 4:30 p.m. ET. A live webcast and slide presentation to accompany the conference call will be available on the Investors section of the Company’s website. The conference call dial-in numbers are (877) 705-2976 for domestic callers and (201) 689-8798 for international callers, and the passcode is 13732962.

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A recording of the call will be available for 48 hours beginning approximately two hours after the completion of the call by dialing (877) 660-6853 for domestic callers or (201) 612-7415 for international callers. Please use the passcode 13726635 to access the recording. A webcast replay will be available on the Investors section of www.codexis.com for 30 days, beginning approximately two hours after the completion of the call.

About Codexis

Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® platform to discover and develop novel, high performance enzymes and biotherapeutics. Codexis enzymes have applications in the sustainable manufacturing of pharmaceuticals, food and industrial products; in the creation of the next generation of life science tools; and as gene therapy and oral enzyme therapies. The Company’s unique performance enzymes drive improvements such as: reduced energy usage, waste generation and capital requirements; higher yields; higher fidelity diagnostics; and more efficacious therapeutics. Codexis enzymes enable the promise of synthetic biology to improve the health of people and the planet. For more information, visit www.codexis.com.

Forward-Looking Statements

To the extent that statements contained in this press release are not descriptions of historical facts regarding Codexis, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, without limitation, Codexis’ expectations regarding 2022 total revenues, product revenues and gross margin on product revenue, its ability to fund planned operations through the end of 2024, and the ability of its evolved strategy to drive long-term success and increased market penetration to deliver value for Codexis customers and shareholders. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond Codexis’ control and that could materially affect actual results. Factors that could materially affect actual results include, among others: Codexis’ dependence on its licensees and collaborators; Codexis’ dependence on a limited number of products and customers, and potential adverse effects to Codexis’ business if its customers’ products are not received well in the markets. Additional information about factors that could materially affect actual results can be found in Codexis’ Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on February 28, 2022 and in Codexis’ Quarterly Report on Form 10-Q filed with the SEC on August 5, 2022, including under the caption “Risk Factors,” and in Codexis’ other periodic reports filed with the SEC. Codexis expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law.

Investor Relations Contact:

Argot Partners
Brendan Strong/Carrie McKim
(212) 600-1902
Codexis@argotpartners.com


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Codexis, Inc.
Condensed Consolidated Statements of Operations
(Unaudited)
(In Thousands, Except Per Share Amounts)

 Three Months Ended September 30,Nine Months Ended September 30,
 2022202120222021
Revenues:
Product revenue$28,042 $28,731 $93,376 $53,674 
Research and development revenue6,428 8,038 14,839 26,579 
Total revenues34,470 36,769 108,215 80,253 
Costs and operating expenses:
Cost of product revenue9,786 6,867 29,577 15,403 
Research and development21,821 15,165 60,410 39,562 
Selling, general and administrative13,499 13,407 39,859 37,600 
Total costs and operating expenses45,106 35,439 129,846 92,565 
Income (loss) from operations(10,636)1,330 (21,631)(12,312)
Interest income436 41 618 424 
Other income, net216 983 150 920 
Income (loss) before income taxes(9,984)2,354 (20,863)(10,968)
Provision for income taxes8 110 125 121 
Net income (loss)$(9,992)$2,244 $(20,988)$(11,089)
Net income (loss) per share, basic$(0.15)$0.03 $(0.32)$(0.17)
Net income (loss) per share, diluted$(0.15)$0.03 $(0.32)$(0.17)
Weighted average common stock shares used in computing net income (loss) per share, basic65,426 64,628 65,271 64,452 
Weighted average common stock shares used in computing net income (loss) per share, diluted65,426 67,741 65,271 64,452 


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Codexis, Inc.
Condensed Consolidated Balance Sheets
(Unaudited)
(In Thousands)
September 30, 2022December 31, 2021
Assets
Current assets:
Cash and cash equivalents$108,689 $116,797 
Restricted cash, current528 579 
Financial assets:
     Accounts receivable16,527 24,953 
     Contract assets5,867 4,557 
Unbilled receivables7,490 8,558 
        Total financial assets29,884 38,068 
             Less: allowances(109)(416)
         Total financial assets, net29,775 37,652 
Inventories1,623 1,160 
Prepaid expenses and other current assets5,382 5,700 
Total current assets145,997 161,888 
Restricted cash1,520 1,519 
Investment in non-marketable equity securities20,510 14,002 
Right-of-use assets - Operating leases, net40,493 44,095 
Right-of-use assets - Finance leases, net— 17 
Property and equipment, net23,319 21,345 
Goodwill3,241 3,241 
Other non-current assets208 276 
Total assets$235,288 $246,383 
Liabilities and Stockholders' Equity
Current liabilities:
Accounts payable$2,621 $2,995 
Accrued compensation9,463 11,119 
Other accrued liabilities12,992 12,578 
Current portion of lease obligations - Operating leases5,230 4,093 
Deferred revenue1,602 2,586 
Total current liabilities31,908 33,371 
Deferred revenue, net of current portion8,238 3,749 
Long-term lease obligations - Operating leases39,655 43,561 
Other long-term liabilities1,356 1,311 
Total liabilities81,157 81,992 
Stockholders' equity:
Common stock6 6 
Additional paid-in capital562,811 552,083 
Accumulated deficit(408,686)(387,698)
Total stockholders' equity154,131 164,391 
Total liabilities and stockholders' equity$235,288 $246,383 

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Codexis, Inc.
Segmented Information
(Unaudited)
(In Thousands)
 Three Months Ended September 30, 2022Three Months Ended September 30, 2021
 Performance EnzymesNovel BiotherapeuticsTotalPerformance EnzymesNovel BiotherapeuticsTotal
Revenues:
Product revenue$28,042 $— $28,042 $28,731 $— $28,731 
Research and development revenue3,104 3,324 6,428 3,853 4,185 8,038 
Total revenues31,146 3,324 34,470 32,584 4,185 36,769 
Costs and operating expenses:
Cost of product revenue9,786 — 9,786 6,867 — 6,867 
Research and development(1)
6,782 13,855 20,637 5,670 8,850 14,520 
Selling, general and administrative(1)
3,791 888 4,679 3,306 831 4,137 
Total segment costs and operating expenses20,359 14,743 35,102 15,843 9,681 25,524 
Income (loss) from operations$10,787 $(11,419)(632)$16,741 $(5,496)11,245 
Corporate costs(2)
(7,947)(8,097)
Unallocated depreciation and amortization(1,405)(794)
Income (loss) before income taxes$(9,984)$2,354 
(1) Research and development expenses and selling, general and administrative expenses exclude depreciation and amortization of finance leases.
(2) Corporate costs include unallocated selling, general and administrative expense, interest income, and other income, net.


 Nine Months Ended September 30, 2022Nine Months Ended September 30, 2021
 Performance EnzymesNovel BiotherapeuticsTotalPerformance EnzymesNovel BiotherapeuticsTotal
Revenues:
Product revenue$93,376 $— $93,376 $53,674 $— $53,674 
Research and development revenue7,398 7,441 14,839 14,723 11,856 26,579 
Total revenues100,774 7,441 108,215 68,397 11,856 80,253 
Costs and operating expenses:
Cost of product revenue29,577 — 29,577 15,403 — 15,403 
Research and development(1)
19,833 37,279 57,112 17,172 20,649 37,821 
Selling, general and administrative(1)
11,208 2,288 13,496 9,294 2,052 11,346 
Total segment costs and operating expenses60,618 39,567 100,185 41,869 22,701 64,570 
Income (loss) from operations$40,156 $(32,126)8,030 $26,528 $(10,845)15,683 
Corporate costs(2)
(24,940)(24,431)
Unallocated depreciation and amortization(3,953)(2,220)
Loss before income taxes$(20,863)$(10,968)
(1) Research and development expenses and selling, general and administrative expenses exclude depreciation and amortization of finance leases.
(2) Corporate costs include unallocated selling, general and administrative expense, interest income, and other income, net.



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