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This Amendment No. 3 to Enzyme Supply Agreement (this “Amendment”) is made as of March 30, 2023 (the “Amendment Effective Date”), between Codexis, Inc., a Delaware corporation having its principal offices at 200 Penobscot Drive, Redwood City, California 94063 (“Codexis”) and Pfizer Ireland Pharmaceuticals, an Ireland corporation, with its principal place of business at Operations Support Group, Ringaskiddy, Cork, Ireland, and its Affiliates (“Pfizer”). Codexis and Pfizer may each be referred to herein individually as a “Party” or collectively, as the “Parties.”

WHEREAS, Pfizer and Codexis are parties to that certain Enzyme Supply Agreement dated as of October 30, 2021 (as amended, the “Agreement”); and

NOW THEREFORE, in consideration of the promises and undertakings set forth herein, the Agreement is hereby amended as follows:

“(b) 100% of any fees invoiced by Codexis to Pfizer during the period January 1, 2022 through December 31, 2023 under mutually acceptable, executed, written definitive collaborative development/licensing agreement(s) (not including this Agreement) executed by Codexis and Pfizer from the Effective Date through April 4, 2023. For clarity, such agreements may include standalone purchase orders.”

IN WITNESS WHEREOF, a duly authorized representative of each Party has executed this Amendment as of the dates identified below, but this Amendment shall become effective on the Amendment Effective Date.


Codexis, Inc.			Pfizer Ireland Pharmaceuticals
Name: Kevin Norrett Title: Chief Operating Officer Date:			Name: Title: Date:


For Codexis, Inc. use only Reviewed by			Legal