Pharmaceutical Biocatalysis

Validated by Performance; Trusted by Global Partners

Using our foundational CodeEvolver® machine learning and AI based platform, which seamlessly integrates the latest computational predictive tools with experimental workflows, we have built a 20-year history of engineering custom enzymes. Codexis’ custom engineered enzymes are used to overcome challenges in the chemical synthesis and manufacturing some of the largest drug products, including Januvia and Paxlovid, among others.

Pharmaceutical Biocatalysis Solutions

Codexis offers a full range of enzyme panels and screening kits as well as custom R&D support to help you get started with biocatalysis.

Enzyme Screening Kits and Panels

Codexis screening kits contain carefully selected enzymes engineered for enhanced activity, selectivity, substrate range, and stability. Check out our most popular KRED and ATA screening kits.

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Enabling Small Molecule Biocatalysis Manufacturing Processes

Highly customized biocatalysts can transform active pharmaceutical ingredients (API) manufacturing processes by eliminating steps, increasing yield, and reducing solvent usage and waste. Carefully designed multi-step, biocatalytic cascades can be assembled in single reactors to accomplish difficult chemical reactions under mild reaction conditions, expanding the capability and the efficiency of biocatalytic processes at large scale.

Codexis is one of the world’s leading enzyme engineering companies

Codexis enzymes are found in over 50 commercialized products and our capabilities are unmatched in turnaround time, manufacturing scale-up – even to metric ton quantities - as well as the quality of our enzyme products. Contact us to discuss your small molecule biocatalysis needs.

We enable the scalable and efficient manufacturing of complex therapeutics.

Our enzymatic tools and platforms enable the scalable and sustainable manufacture of small molecule API and siRNA for our customers while reducing costs and time of manufacturing. Contact us today to learn more about how we can scale your capabilities.

Related Resources

Amine Transminase for Chiral Sacubitril Precursor Production

Starting from an enzyme with trace activity, 11 rounds of enzyme evolution were performed for the efficient production of a precursor to Entresto, the blockbuster heart failure drug.

Enzyme Evolution for Industrial Biocatalytic Cascades

Industrially relevant enzyme cascades can accomplish difficult chemistry under mild reaction conditions, with minimal waste generation and attractive economics.

The Future of Small Molecule API Synthesis

Optimal route design for small molecule API synthesis under a state of control with a reproducible impurity profile at increasing scale in an economical fashion.